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Inguinal or inguino-iliac/obturator lymph node dissection after positive inguinal sentinel lymph node in patients with cutaneous melanoma.

Glumac N, Hocevar M, Zadnik V, Snoj M - Radiol Oncol (2012)

Bottom Line: Micrometastases in inguinal SLN were detected in 32 patients, 14 were single, 2 were double, and 16 were multiple.Twenty-six patients had macrometastases.In these cases respective CLND might be omitted.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology, Institute of Oncology, Ljubljana, Slovenia.

ABSTRACT

Background: The aim of the study was to determine whether the presence of inguinal sentinel lymph node (SLN) metastases smaller than 2 mm (micrometastases) subdivided according to the number of micrometastases predicts additional, non-sentinel inguinal, iliac or obturator lymph node involvement in completion lymph node dissection (CLND). PATIENTS AND METHODS.: Positive inguinal SLN was detected in 58 patients (32 female, 26 male, median age 55 years) from 743 consecutive and prospectively enrolled patients with primary cutaneous melanoma stage I and II who were treated with SLN biopsy between 2001 and 2007.

Results: Micrometastases in inguinal SLN were detected in 32 patients, 14 were single, 2 were double, and 16 were multiple. Twenty-six patients had macrometastases.

Conclusions: No patient with any micrometastases or a single SLN macrometastasis in the inguinal region had any iliac/obturator non-sentinel metastases after CLND in our series. Furthermore, no patient with single SLN micrometastasis in the inguinal region had any non-sentinel metastases at all after CLND in our series. In these cases respective CLND might be omitted.

No MeSH data available.


Related in: MedlinePlus

The log rank test of Kaplan-Meier overall survival curves for patients after positive inguinal SLN compared to patients after palpable inguinal metastases (p = 0.028).
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f2-rado-46-03-258: The log rank test of Kaplan-Meier overall survival curves for patients after positive inguinal SLN compared to patients after palpable inguinal metastases (p = 0.028).

Mentions: The log rank test of Kaplan-Meier survival curves showed a statistically significant better overall survival (Figure 2, p = 0.028) for patients with positive inguinal SLNB (77.1% survival at 2 years, CI 64.4% - 89.8%, median follow up 1.9 years) than for patients with palpable inguinal metastases (70.5% survival at 2 years, CI 60.3% - 807%, median follow up 3.3 years).


Inguinal or inguino-iliac/obturator lymph node dissection after positive inguinal sentinel lymph node in patients with cutaneous melanoma.

Glumac N, Hocevar M, Zadnik V, Snoj M - Radiol Oncol (2012)

The log rank test of Kaplan-Meier overall survival curves for patients after positive inguinal SLN compared to patients after palpable inguinal metastases (p = 0.028).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3472950&req=5

f2-rado-46-03-258: The log rank test of Kaplan-Meier overall survival curves for patients after positive inguinal SLN compared to patients after palpable inguinal metastases (p = 0.028).
Mentions: The log rank test of Kaplan-Meier survival curves showed a statistically significant better overall survival (Figure 2, p = 0.028) for patients with positive inguinal SLNB (77.1% survival at 2 years, CI 64.4% - 89.8%, median follow up 1.9 years) than for patients with palpable inguinal metastases (70.5% survival at 2 years, CI 60.3% - 807%, median follow up 3.3 years).

Bottom Line: Micrometastases in inguinal SLN were detected in 32 patients, 14 were single, 2 were double, and 16 were multiple.Twenty-six patients had macrometastases.In these cases respective CLND might be omitted.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology, Institute of Oncology, Ljubljana, Slovenia.

ABSTRACT

Background: The aim of the study was to determine whether the presence of inguinal sentinel lymph node (SLN) metastases smaller than 2 mm (micrometastases) subdivided according to the number of micrometastases predicts additional, non-sentinel inguinal, iliac or obturator lymph node involvement in completion lymph node dissection (CLND). PATIENTS AND METHODS.: Positive inguinal SLN was detected in 58 patients (32 female, 26 male, median age 55 years) from 743 consecutive and prospectively enrolled patients with primary cutaneous melanoma stage I and II who were treated with SLN biopsy between 2001 and 2007.

Results: Micrometastases in inguinal SLN were detected in 32 patients, 14 were single, 2 were double, and 16 were multiple. Twenty-six patients had macrometastases.

Conclusions: No patient with any micrometastases or a single SLN macrometastasis in the inguinal region had any iliac/obturator non-sentinel metastases after CLND in our series. Furthermore, no patient with single SLN micrometastasis in the inguinal region had any non-sentinel metastases at all after CLND in our series. In these cases respective CLND might be omitted.

No MeSH data available.


Related in: MedlinePlus