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Cathepsin X in serum from patients with colorectal cancer: relation to prognosis.

Vizin T, Christensen IJ, Nielsen HJ, Kos J - Radiol Oncol (2012)

Bottom Line: Up-regulation of lysosomal cysteine protease cathepsin X (Cat X) is associated with disorders of the immune system and neurodegenerative diseases, while its role in the development and progression of cancer is less understood.Within the group of CRC, higher levels of total Cat X significantly correlated to shorter overall survival (HR=2.08, 95% CI:1.07-4.05, p=0.028).Total serum Cat X could be a useful prognostic indicator for determining survival of patients with CRC.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.

ABSTRACT

Background: Up-regulation of lysosomal cysteine protease cathepsin X (Cat X) is associated with disorders of the immune system and neurodegenerative diseases, while its role in the development and progression of cancer is less understood. Enhanced secretion of pro-Cat X was observed in malignant processes, and therefore, the level of total serum Cat X rather than the active enzyme may better reflect the tumour status.

Patients and methods: Seventy-seven patients with colorectal cancer (CRC) were included in a retrospective study. Blood samples were collected prior to therapy. Using ELISA, the values of total Cat X were measured in serum. Groups of healthy persons (n=77), patients with adenomas (n=77) and patients with non-neoplastic findings (n=77) were included.

Results: Significant differences between the group of colorectal patients and the groups of healthy persons, adenoma patients and patients with non-malignant findings could not be shown (p=0.89). Within the group of CRC, higher levels of total Cat X significantly correlated to shorter overall survival (HR=2.08, 95% CI:1.07-4.05, p=0.028).

Conclusions: Total serum Cat X could be a useful prognostic indicator for determining survival of patients with CRC. Increased serum levels of total Cat X may reflect more aggressive tumour cell phenotypes and suggest the involvement of Cat X in processes involved in later stages of tumour progression.

No MeSH data available.


Related in: MedlinePlus

Survival analysis of cathepsin X in serum from patients with CRC. The Kaplan-Meier curve dichotomizing by the median shows the association between total Cat X serum concentrations and patient overall survival. Red colour represents a group of patients with high Cat X levels (≥ to median), blue colour represents a group of patients with low Cat X levels (< to median).
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f1-rado-46-03-207: Survival analysis of cathepsin X in serum from patients with CRC. The Kaplan-Meier curve dichotomizing by the median shows the association between total Cat X serum concentrations and patient overall survival. Red colour represents a group of patients with high Cat X levels (≥ to median), blue colour represents a group of patients with low Cat X levels (< to median).

Mentions: The survival analysis (Figure 1) shows an association between total Cat X serum concentrations and overall survival of CRC patients. The log rank statistics show that patients with higher serum levels of total Cat X have shorter survival than the patients with lower total Cat X serum levels (p=0.028; HR=2.08 (95% CI: 1.07–4.05)). On the continuous scale the difference was not significant (p=0.19; HR=1.48 (95% CI: 0.83–2.64)).


Cathepsin X in serum from patients with colorectal cancer: relation to prognosis.

Vizin T, Christensen IJ, Nielsen HJ, Kos J - Radiol Oncol (2012)

Survival analysis of cathepsin X in serum from patients with CRC. The Kaplan-Meier curve dichotomizing by the median shows the association between total Cat X serum concentrations and patient overall survival. Red colour represents a group of patients with high Cat X levels (≥ to median), blue colour represents a group of patients with low Cat X levels (< to median).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3472949&req=5

f1-rado-46-03-207: Survival analysis of cathepsin X in serum from patients with CRC. The Kaplan-Meier curve dichotomizing by the median shows the association between total Cat X serum concentrations and patient overall survival. Red colour represents a group of patients with high Cat X levels (≥ to median), blue colour represents a group of patients with low Cat X levels (< to median).
Mentions: The survival analysis (Figure 1) shows an association between total Cat X serum concentrations and overall survival of CRC patients. The log rank statistics show that patients with higher serum levels of total Cat X have shorter survival than the patients with lower total Cat X serum levels (p=0.028; HR=2.08 (95% CI: 1.07–4.05)). On the continuous scale the difference was not significant (p=0.19; HR=1.48 (95% CI: 0.83–2.64)).

Bottom Line: Up-regulation of lysosomal cysteine protease cathepsin X (Cat X) is associated with disorders of the immune system and neurodegenerative diseases, while its role in the development and progression of cancer is less understood.Within the group of CRC, higher levels of total Cat X significantly correlated to shorter overall survival (HR=2.08, 95% CI:1.07-4.05, p=0.028).Total serum Cat X could be a useful prognostic indicator for determining survival of patients with CRC.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.

ABSTRACT

Background: Up-regulation of lysosomal cysteine protease cathepsin X (Cat X) is associated with disorders of the immune system and neurodegenerative diseases, while its role in the development and progression of cancer is less understood. Enhanced secretion of pro-Cat X was observed in malignant processes, and therefore, the level of total serum Cat X rather than the active enzyme may better reflect the tumour status.

Patients and methods: Seventy-seven patients with colorectal cancer (CRC) were included in a retrospective study. Blood samples were collected prior to therapy. Using ELISA, the values of total Cat X were measured in serum. Groups of healthy persons (n=77), patients with adenomas (n=77) and patients with non-neoplastic findings (n=77) were included.

Results: Significant differences between the group of colorectal patients and the groups of healthy persons, adenoma patients and patients with non-malignant findings could not be shown (p=0.89). Within the group of CRC, higher levels of total Cat X significantly correlated to shorter overall survival (HR=2.08, 95% CI:1.07-4.05, p=0.028).

Conclusions: Total serum Cat X could be a useful prognostic indicator for determining survival of patients with CRC. Increased serum levels of total Cat X may reflect more aggressive tumour cell phenotypes and suggest the involvement of Cat X in processes involved in later stages of tumour progression.

No MeSH data available.


Related in: MedlinePlus