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The antitumor efficiency of combined electrochemotherapy and single dose irradiation on a breast cancer tumor model.

Raeisi E, Aghamiri SM, Bandi A, Rahmatpour N, Firoozabadi SM, Kafi-Abad SA, Mir LM - Radiol Oncol (2012)

Bottom Line: Antitumor effectiveness was evaluated by tumor growth delay, tumor-doubling time, inhibition ratio and the objective response rates.In general the higher 5 Gy dose of γ-radiation was more effective than the lower one of 3 Gy.Good antitumor results were achieved in experimental tumors with a size comparable to clinical lesions, demonstrating that this three-modality combined treatment is useful for the treatment of large lesions even at sub-optimal radiotherapy doses.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Physics, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran ; Faculty of Science, University of Geneve, Geneve, Switzerland.

ABSTRACT

Background: The aim of this study was to investigate the antitumor effectiveness of electrochemotherapy with cisplatin combined with suboptimal radiotherapy doses. Tumor radiosensitization was evaluated on large invasive ductal carcinoma tumors in Balb/C mice.

Materials and methods: Tumors of an average volume of 630 mm(3) were treated with cisplatin, electric pulses, radiotherapy, electrochemotherapy, alone as well as in appropriate combinations. Tumors were irradiated with Cobalt-60 γ-rays at doses 3 Gy and 5 Gy in combination with electrochemotherapy using cisplatin. Controls included each of the treatments alone as well as the combination of the radiotherapy with electric pulses alone or with cisplatin alone. Antitumor effectiveness was evaluated by tumor growth delay, tumor-doubling time, inhibition ratio and the objective response rates.

Results: As anticipated, electrochemotherapy was more effective than the treatment with cisplatin alone or the application of the electric pulses alone. When treatments were combined with tumor irradiation at either 3 or 5 Gy, the combination with electrochemotherapy was more effective: at 5 Gy, 2 animals out of 8 were in complete remission 100 days later. In general the higher 5 Gy dose of γ-radiation was more effective than the lower one of 3 Gy.

Conclusions: The results of our study demonstrate that irradiation doses, 3 Gy or 5 Gy, increase the antitumor effectiveness of electrochemotherapy with cisplatin on invasive ductal carcinoma tumors. Good antitumor results were achieved in experimental tumors with a size comparable to clinical lesions, demonstrating that this three-modality combined treatment is useful for the treatment of large lesions even at sub-optimal radiotherapy doses.

No MeSH data available.


Related in: MedlinePlus

Individual tumor growth curves of tumors treated by the combination of electrochemotherapy (ECT) and radiotherapy at the dose of 5 Gy.
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f3-rado-46-03-226: Individual tumor growth curves of tumors treated by the combination of electrochemotherapy (ECT) and radiotherapy at the dose of 5 Gy.

Mentions: Irradiation of tumors pretreated with electrochemotherapy prolonged the tumor growth delay up to 25.7 days and 38.6 days at 3 Gy and 5 Gy respectively. The inhibition ratio reached 76% for the 3 Gy irradiation and 87% for 5 Gy. Ten per cent of partial responses after 30 days were observed with electrochemotherapy followed by 3 Gy, though without complete responders. In contrast, the electrochemotherapy with a 5 Gy irradiation resulted in a higher percentage of partial regressions (37% of the tumors were still in partial response 30 days after the treatment). Moreover, 25% of the mice were still in complete remission 100 days after the treatment (Table 1 and Figure 3). Again, the combination with 5 Gy was significantly (p <0.05) more efficient than the combination with 3 Gy. Even in this group, no body weight loss or skin desquamation was reported. Only a hair loss was observed in all the groups that were irradiated, locally at the level of the irradiation site.


The antitumor efficiency of combined electrochemotherapy and single dose irradiation on a breast cancer tumor model.

Raeisi E, Aghamiri SM, Bandi A, Rahmatpour N, Firoozabadi SM, Kafi-Abad SA, Mir LM - Radiol Oncol (2012)

Individual tumor growth curves of tumors treated by the combination of electrochemotherapy (ECT) and radiotherapy at the dose of 5 Gy.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3472947&req=5

f3-rado-46-03-226: Individual tumor growth curves of tumors treated by the combination of electrochemotherapy (ECT) and radiotherapy at the dose of 5 Gy.
Mentions: Irradiation of tumors pretreated with electrochemotherapy prolonged the tumor growth delay up to 25.7 days and 38.6 days at 3 Gy and 5 Gy respectively. The inhibition ratio reached 76% for the 3 Gy irradiation and 87% for 5 Gy. Ten per cent of partial responses after 30 days were observed with electrochemotherapy followed by 3 Gy, though without complete responders. In contrast, the electrochemotherapy with a 5 Gy irradiation resulted in a higher percentage of partial regressions (37% of the tumors were still in partial response 30 days after the treatment). Moreover, 25% of the mice were still in complete remission 100 days after the treatment (Table 1 and Figure 3). Again, the combination with 5 Gy was significantly (p <0.05) more efficient than the combination with 3 Gy. Even in this group, no body weight loss or skin desquamation was reported. Only a hair loss was observed in all the groups that were irradiated, locally at the level of the irradiation site.

Bottom Line: Antitumor effectiveness was evaluated by tumor growth delay, tumor-doubling time, inhibition ratio and the objective response rates.In general the higher 5 Gy dose of γ-radiation was more effective than the lower one of 3 Gy.Good antitumor results were achieved in experimental tumors with a size comparable to clinical lesions, demonstrating that this three-modality combined treatment is useful for the treatment of large lesions even at sub-optimal radiotherapy doses.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Physics, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran ; Faculty of Science, University of Geneve, Geneve, Switzerland.

ABSTRACT

Background: The aim of this study was to investigate the antitumor effectiveness of electrochemotherapy with cisplatin combined with suboptimal radiotherapy doses. Tumor radiosensitization was evaluated on large invasive ductal carcinoma tumors in Balb/C mice.

Materials and methods: Tumors of an average volume of 630 mm(3) were treated with cisplatin, electric pulses, radiotherapy, electrochemotherapy, alone as well as in appropriate combinations. Tumors were irradiated with Cobalt-60 γ-rays at doses 3 Gy and 5 Gy in combination with electrochemotherapy using cisplatin. Controls included each of the treatments alone as well as the combination of the radiotherapy with electric pulses alone or with cisplatin alone. Antitumor effectiveness was evaluated by tumor growth delay, tumor-doubling time, inhibition ratio and the objective response rates.

Results: As anticipated, electrochemotherapy was more effective than the treatment with cisplatin alone or the application of the electric pulses alone. When treatments were combined with tumor irradiation at either 3 or 5 Gy, the combination with electrochemotherapy was more effective: at 5 Gy, 2 animals out of 8 were in complete remission 100 days later. In general the higher 5 Gy dose of γ-radiation was more effective than the lower one of 3 Gy.

Conclusions: The results of our study demonstrate that irradiation doses, 3 Gy or 5 Gy, increase the antitumor effectiveness of electrochemotherapy with cisplatin on invasive ductal carcinoma tumors. Good antitumor results were achieved in experimental tumors with a size comparable to clinical lesions, demonstrating that this three-modality combined treatment is useful for the treatment of large lesions even at sub-optimal radiotherapy doses.

No MeSH data available.


Related in: MedlinePlus