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The antitumor efficiency of combined electrochemotherapy and single dose irradiation on a breast cancer tumor model.

Raeisi E, Aghamiri SM, Bandi A, Rahmatpour N, Firoozabadi SM, Kafi-Abad SA, Mir LM - Radiol Oncol (2012)

Bottom Line: Antitumor effectiveness was evaluated by tumor growth delay, tumor-doubling time, inhibition ratio and the objective response rates.In general the higher 5 Gy dose of γ-radiation was more effective than the lower one of 3 Gy.Good antitumor results were achieved in experimental tumors with a size comparable to clinical lesions, demonstrating that this three-modality combined treatment is useful for the treatment of large lesions even at sub-optimal radiotherapy doses.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Physics, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran ; Faculty of Science, University of Geneve, Geneve, Switzerland.

ABSTRACT

Background: The aim of this study was to investigate the antitumor effectiveness of electrochemotherapy with cisplatin combined with suboptimal radiotherapy doses. Tumor radiosensitization was evaluated on large invasive ductal carcinoma tumors in Balb/C mice.

Materials and methods: Tumors of an average volume of 630 mm(3) were treated with cisplatin, electric pulses, radiotherapy, electrochemotherapy, alone as well as in appropriate combinations. Tumors were irradiated with Cobalt-60 γ-rays at doses 3 Gy and 5 Gy in combination with electrochemotherapy using cisplatin. Controls included each of the treatments alone as well as the combination of the radiotherapy with electric pulses alone or with cisplatin alone. Antitumor effectiveness was evaluated by tumor growth delay, tumor-doubling time, inhibition ratio and the objective response rates.

Results: As anticipated, electrochemotherapy was more effective than the treatment with cisplatin alone or the application of the electric pulses alone. When treatments were combined with tumor irradiation at either 3 or 5 Gy, the combination with electrochemotherapy was more effective: at 5 Gy, 2 animals out of 8 were in complete remission 100 days later. In general the higher 5 Gy dose of γ-radiation was more effective than the lower one of 3 Gy.

Conclusions: The results of our study demonstrate that irradiation doses, 3 Gy or 5 Gy, increase the antitumor effectiveness of electrochemotherapy with cisplatin on invasive ductal carcinoma tumors. Good antitumor results were achieved in experimental tumors with a size comparable to clinical lesions, demonstrating that this three-modality combined treatment is useful for the treatment of large lesions even at sub-optimal radiotherapy doses.

No MeSH data available.


Related in: MedlinePlus

Tumor growth curves in untreated tumors or after treatment with CDDP (CDDP), electric pulses (EP) only, irradiation (IR) only, electrochemotherapy (ECT) and the combinations of CDDP or electric pulses and radiotherapy. Data are mean ± SE of at least 8 animals for each of the experimental groups. Irradiation of tumor was 3Gy.
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f1-rado-46-03-226: Tumor growth curves in untreated tumors or after treatment with CDDP (CDDP), electric pulses (EP) only, irradiation (IR) only, electrochemotherapy (ECT) and the combinations of CDDP or electric pulses and radiotherapy. Data are mean ± SE of at least 8 animals for each of the experimental groups. Irradiation of tumor was 3Gy.

Mentions: As shown in Table 1 and Figure 1, cisplatin (at a dose of 8 mg/kg) as a single treatment delayed the tumor growth up to 5.5 days with an inhibition ratio of 33%. Tumors that were treated with electric pulses alone (8 pulses, 1000 V/cm, 100μs duration, at 1 Hz repetition frequency) displayed a tumor growth delay of only 2 days with an inhibition ratio of 32% (Table 1) and with no partial or complete responders with neither of both treatment modalities.


The antitumor efficiency of combined electrochemotherapy and single dose irradiation on a breast cancer tumor model.

Raeisi E, Aghamiri SM, Bandi A, Rahmatpour N, Firoozabadi SM, Kafi-Abad SA, Mir LM - Radiol Oncol (2012)

Tumor growth curves in untreated tumors or after treatment with CDDP (CDDP), electric pulses (EP) only, irradiation (IR) only, electrochemotherapy (ECT) and the combinations of CDDP or electric pulses and radiotherapy. Data are mean ± SE of at least 8 animals for each of the experimental groups. Irradiation of tumor was 3Gy.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3472947&req=5

f1-rado-46-03-226: Tumor growth curves in untreated tumors or after treatment with CDDP (CDDP), electric pulses (EP) only, irradiation (IR) only, electrochemotherapy (ECT) and the combinations of CDDP or electric pulses and radiotherapy. Data are mean ± SE of at least 8 animals for each of the experimental groups. Irradiation of tumor was 3Gy.
Mentions: As shown in Table 1 and Figure 1, cisplatin (at a dose of 8 mg/kg) as a single treatment delayed the tumor growth up to 5.5 days with an inhibition ratio of 33%. Tumors that were treated with electric pulses alone (8 pulses, 1000 V/cm, 100μs duration, at 1 Hz repetition frequency) displayed a tumor growth delay of only 2 days with an inhibition ratio of 32% (Table 1) and with no partial or complete responders with neither of both treatment modalities.

Bottom Line: Antitumor effectiveness was evaluated by tumor growth delay, tumor-doubling time, inhibition ratio and the objective response rates.In general the higher 5 Gy dose of γ-radiation was more effective than the lower one of 3 Gy.Good antitumor results were achieved in experimental tumors with a size comparable to clinical lesions, demonstrating that this three-modality combined treatment is useful for the treatment of large lesions even at sub-optimal radiotherapy doses.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Physics, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran ; Faculty of Science, University of Geneve, Geneve, Switzerland.

ABSTRACT

Background: The aim of this study was to investigate the antitumor effectiveness of electrochemotherapy with cisplatin combined with suboptimal radiotherapy doses. Tumor radiosensitization was evaluated on large invasive ductal carcinoma tumors in Balb/C mice.

Materials and methods: Tumors of an average volume of 630 mm(3) were treated with cisplatin, electric pulses, radiotherapy, electrochemotherapy, alone as well as in appropriate combinations. Tumors were irradiated with Cobalt-60 γ-rays at doses 3 Gy and 5 Gy in combination with electrochemotherapy using cisplatin. Controls included each of the treatments alone as well as the combination of the radiotherapy with electric pulses alone or with cisplatin alone. Antitumor effectiveness was evaluated by tumor growth delay, tumor-doubling time, inhibition ratio and the objective response rates.

Results: As anticipated, electrochemotherapy was more effective than the treatment with cisplatin alone or the application of the electric pulses alone. When treatments were combined with tumor irradiation at either 3 or 5 Gy, the combination with electrochemotherapy was more effective: at 5 Gy, 2 animals out of 8 were in complete remission 100 days later. In general the higher 5 Gy dose of γ-radiation was more effective than the lower one of 3 Gy.

Conclusions: The results of our study demonstrate that irradiation doses, 3 Gy or 5 Gy, increase the antitumor effectiveness of electrochemotherapy with cisplatin on invasive ductal carcinoma tumors. Good antitumor results were achieved in experimental tumors with a size comparable to clinical lesions, demonstrating that this three-modality combined treatment is useful for the treatment of large lesions even at sub-optimal radiotherapy doses.

No MeSH data available.


Related in: MedlinePlus