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Intensity modulated radiation therapy (IMRT) for the treatment of unicentric Castlemans disease: a case report and review of the use of radiotherapy in the literature.

Matthiesen C, Ramgopol R, Seavey J, Ahmad S, Herman T - Radiol Oncol (2012)

Bottom Line: A 47 year old female was found to have an intra-thoracic posterior UCD and was determined not to be a good surgical candidate.Neither disease progression nor late effects have occurred.The use of IMRT and planned treatment break was successful in the treatment of a case of UCD, and should be considered for other unresectable cases.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

ABSTRACT

Background: Surgical resection is considered standard therapy for cases of resectable unicentric Castleman's disease (UCD). Unresectable cases of UCD do not have a consensus regarding the optimal treatment approach, but have utilized steroids, observation, chemotherapy, and radiotherapy. Here we discuss a patient presentation of UCD treated with an advanced radiotherapy technique, IMRT.

Case report: A 47 year old female was found to have an intra-thoracic posterior UCD and was determined not to be a good surgical candidate. She was referred for radiotherapy and was treated using IMRT to a total dose of 4320 cGy in 180 cGy fractions including a scheduled 10 day break. Following the break, the patient's treatment was replanned at which the initial treatment volume was reduced by 50.9% for the duration of the treatment course. Radiation Therapy Oncology Group (RTOG) grade III pneumonitis developed which was managed medically. Neither disease progression nor late effects have occurred.

Conclusions: The use of IMRT and planned treatment break was successful in the treatment of a case of UCD, and should be considered for other unresectable cases.

No MeSH data available.


Related in: MedlinePlus

CT at four months post-RT. The mass is noted to be smaller.
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f6-rado-46-03-265: CT at four months post-RT. The mass is noted to be smaller.

Mentions: At a follow-up of ten months, the patient has had no disease progression. She did develop RTOG grade III pneumonitis at three months follow-up which was managed by steroids. Follow-up PETCT (Figure 6) showed the mass to be stable at 3.9 cmx 5.1 cm and SUV values to be at background. No late effects have occurred.


Intensity modulated radiation therapy (IMRT) for the treatment of unicentric Castlemans disease: a case report and review of the use of radiotherapy in the literature.

Matthiesen C, Ramgopol R, Seavey J, Ahmad S, Herman T - Radiol Oncol (2012)

CT at four months post-RT. The mass is noted to be smaller.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3472945&req=5

f6-rado-46-03-265: CT at four months post-RT. The mass is noted to be smaller.
Mentions: At a follow-up of ten months, the patient has had no disease progression. She did develop RTOG grade III pneumonitis at three months follow-up which was managed by steroids. Follow-up PETCT (Figure 6) showed the mass to be stable at 3.9 cmx 5.1 cm and SUV values to be at background. No late effects have occurred.

Bottom Line: A 47 year old female was found to have an intra-thoracic posterior UCD and was determined not to be a good surgical candidate.Neither disease progression nor late effects have occurred.The use of IMRT and planned treatment break was successful in the treatment of a case of UCD, and should be considered for other unresectable cases.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

ABSTRACT

Background: Surgical resection is considered standard therapy for cases of resectable unicentric Castleman's disease (UCD). Unresectable cases of UCD do not have a consensus regarding the optimal treatment approach, but have utilized steroids, observation, chemotherapy, and radiotherapy. Here we discuss a patient presentation of UCD treated with an advanced radiotherapy technique, IMRT.

Case report: A 47 year old female was found to have an intra-thoracic posterior UCD and was determined not to be a good surgical candidate. She was referred for radiotherapy and was treated using IMRT to a total dose of 4320 cGy in 180 cGy fractions including a scheduled 10 day break. Following the break, the patient's treatment was replanned at which the initial treatment volume was reduced by 50.9% for the duration of the treatment course. Radiation Therapy Oncology Group (RTOG) grade III pneumonitis developed which was managed medically. Neither disease progression nor late effects have occurred.

Conclusions: The use of IMRT and planned treatment break was successful in the treatment of a case of UCD, and should be considered for other unresectable cases.

No MeSH data available.


Related in: MedlinePlus