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Imaging primary prostate cancer with 11C-Choline PET/CT: relation to tumour stage, Gleason score and biomarkers of biologic aggressiveness.

Chen J, Zhao Y, Li X, Sun P, Wang M, Wang R, Jin X - Radiol Oncol (2012)

Bottom Line: SUVmax-P/M ratio was also significantly higher in lesions with Gleason score of 4+3 or higher versus less than or equal to 3+4.SUVmax-P/M ratio was found significantly correlated with expression levels of Ki-67 and CD31.At the same time, Gleason score and expression levels of these biomarkers showed no significant association with SUVmax.

View Article: PubMed Central - PubMed

Affiliation: Department of Minimally Invasive Urology center, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China.

ABSTRACT

Background: As a significant overlap of 11C-Choline standardized uptake value (SUV) between prostate cancer and benign prostate hyperplasia (BPH) tissue, controversy exists regarding the clinical value of 11C-Choline PET/CT scan in primary prostate cancer. In this study, the SUVmax of the prostate lesions and the pelvic muscles were measured and their ratios (SUVmax-P/M ratio) were calculated. Then we evaluated whether the tracer 11C-Choline uptake, quantified as SUVmax-P/M ratio, correlated with tumour stage, Gleason score, and expression levels of several biomarkers of aggressiveness.

Methods: Twenty-six patients with primary prostate cancer underwent 11C-Choline PET/CT. Tumour specimens from these patients were graded histopathologically, and immunnohistochemistry for Ki-67, CD31, androgen receptor (AR), Her-2/neu, Bcl-2, and PTEN were performed.

Results: Both SUVmax and SUVmax-P/M ratio showed no significant difference between patients with tumour stage II and III, but significantly elevated in patients with tumour stage IV. SUVmax-P/M ratio was also significantly higher in lesions with Gleason score of 4+3 or higher versus less than or equal to 3+4. SUVmax-P/M ratio was found significantly correlated with expression levels of Ki-67 and CD31. In addition, a higher SUVmax-P/M ratio was demonstrated in Her-2/neu positive subgroup than negative subgroup. At the same time, Gleason score and expression levels of these biomarkers showed no significant association with SUVmax.

Conclusions: Using the parameter SUVmax-P/M ratio, 11C-Choline PET/CT may be a valuable non-invasive imaging technology in the diagnosis of primary prostate cancer.

No MeSH data available.


Related in: MedlinePlus

11C-Choline uptake (measured as SUVmax-P/M ratio) according to tumour stage and Gleason score. SUVmax-P/M ratio was significantly higher in patients with tumour stage or Gleason score > 7(3+4).
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f1-rado-46-03-179: 11C-Choline uptake (measured as SUVmax-P/M ratio) according to tumour stage and Gleason score. SUVmax-P/M ratio was significantly higher in patients with tumour stage or Gleason score > 7(3+4).

Mentions: Association of several clinicopathological factors and expression levels of these molecular markers was then analysed. The mean SUVmax in stages II, III, and IV were 5.88 ± 4.96, 10.69 ± 5.69, and 12.06 ± 7.50. The mean SUVmax-P/M ratio in stages II, III, and IV were 3.62 ± 1.26, 3.93 ± 1.25, and 5.16 ± 1.28. Both SUVmax-P/M ratio and SUVmax showed no significant difference between patients with tumour stage II and III (p-value 0.113 and 0.328, respectively), but significantly elevated in patients with tumour stage IV (p-value 0.036 and 0.015, respectively). Furthermore, SUVmax-P/M ratio was also significantly higher in patients with Gleason score of 4+3 or higher versus less than or equal to 3+4 (Figure 1). The correlation coefficients for SUVmax-P/M ratio with Ki-67 and MVD were 0.503 and 0.545, and the P values for both of these two biomarkers correlations were <0.05 (Figure 2). As shown in Figure 3, SUVmax-P/M raito was higher in Her-2/neu positive subgroup than negative subgroup. In contrast, neither Gleason score nor expression levels of the biomarkers involved in the study associated with SUVmax.


Imaging primary prostate cancer with 11C-Choline PET/CT: relation to tumour stage, Gleason score and biomarkers of biologic aggressiveness.

Chen J, Zhao Y, Li X, Sun P, Wang M, Wang R, Jin X - Radiol Oncol (2012)

11C-Choline uptake (measured as SUVmax-P/M ratio) according to tumour stage and Gleason score. SUVmax-P/M ratio was significantly higher in patients with tumour stage or Gleason score > 7(3+4).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3472944&req=5

f1-rado-46-03-179: 11C-Choline uptake (measured as SUVmax-P/M ratio) according to tumour stage and Gleason score. SUVmax-P/M ratio was significantly higher in patients with tumour stage or Gleason score > 7(3+4).
Mentions: Association of several clinicopathological factors and expression levels of these molecular markers was then analysed. The mean SUVmax in stages II, III, and IV were 5.88 ± 4.96, 10.69 ± 5.69, and 12.06 ± 7.50. The mean SUVmax-P/M ratio in stages II, III, and IV were 3.62 ± 1.26, 3.93 ± 1.25, and 5.16 ± 1.28. Both SUVmax-P/M ratio and SUVmax showed no significant difference between patients with tumour stage II and III (p-value 0.113 and 0.328, respectively), but significantly elevated in patients with tumour stage IV (p-value 0.036 and 0.015, respectively). Furthermore, SUVmax-P/M ratio was also significantly higher in patients with Gleason score of 4+3 or higher versus less than or equal to 3+4 (Figure 1). The correlation coefficients for SUVmax-P/M ratio with Ki-67 and MVD were 0.503 and 0.545, and the P values for both of these two biomarkers correlations were <0.05 (Figure 2). As shown in Figure 3, SUVmax-P/M raito was higher in Her-2/neu positive subgroup than negative subgroup. In contrast, neither Gleason score nor expression levels of the biomarkers involved in the study associated with SUVmax.

Bottom Line: SUVmax-P/M ratio was also significantly higher in lesions with Gleason score of 4+3 or higher versus less than or equal to 3+4.SUVmax-P/M ratio was found significantly correlated with expression levels of Ki-67 and CD31.At the same time, Gleason score and expression levels of these biomarkers showed no significant association with SUVmax.

View Article: PubMed Central - PubMed

Affiliation: Department of Minimally Invasive Urology center, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China.

ABSTRACT

Background: As a significant overlap of 11C-Choline standardized uptake value (SUV) between prostate cancer and benign prostate hyperplasia (BPH) tissue, controversy exists regarding the clinical value of 11C-Choline PET/CT scan in primary prostate cancer. In this study, the SUVmax of the prostate lesions and the pelvic muscles were measured and their ratios (SUVmax-P/M ratio) were calculated. Then we evaluated whether the tracer 11C-Choline uptake, quantified as SUVmax-P/M ratio, correlated with tumour stage, Gleason score, and expression levels of several biomarkers of aggressiveness.

Methods: Twenty-six patients with primary prostate cancer underwent 11C-Choline PET/CT. Tumour specimens from these patients were graded histopathologically, and immunnohistochemistry for Ki-67, CD31, androgen receptor (AR), Her-2/neu, Bcl-2, and PTEN were performed.

Results: Both SUVmax and SUVmax-P/M ratio showed no significant difference between patients with tumour stage II and III, but significantly elevated in patients with tumour stage IV. SUVmax-P/M ratio was also significantly higher in lesions with Gleason score of 4+3 or higher versus less than or equal to 3+4. SUVmax-P/M ratio was found significantly correlated with expression levels of Ki-67 and CD31. In addition, a higher SUVmax-P/M ratio was demonstrated in Her-2/neu positive subgroup than negative subgroup. At the same time, Gleason score and expression levels of these biomarkers showed no significant association with SUVmax.

Conclusions: Using the parameter SUVmax-P/M ratio, 11C-Choline PET/CT may be a valuable non-invasive imaging technology in the diagnosis of primary prostate cancer.

No MeSH data available.


Related in: MedlinePlus