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Biotin-functionalized semiconducting polymer in an organic field effect transistor and application as a biosensor.

Kim ZS, Lim SC, Kim SH, Yang YS, Hwang DH - Sensors (Basel) (2012)

Bottom Line: The side chains of fluorene were partially biotinylated after the esterification of the biotin with corresponding alcohol-groups at the side chain in F8T2.The functionality of this biosensor in the sensing of biologically active molecules such as avidin in comparison with bovine serum albumin (BSA) was established through a selective decrease in the conductivity of the transistor, as measured with a device that was developed by the authors.Changes to the optical properties of this polymer were also measured through the change in the color of the UV-fluorescence before and after a reaction with avidin or BSA.

View Article: PubMed Central - PubMed

Affiliation: Electronics and Telecommunications Research Institute (ETRI), 218 Gajeongno, Yuseong-Gu, Daejeon 305-700, Korea. zinsig.kim@gmail.com

ABSTRACT
This report presents biotin-functionalized semiconducting polymers that are based on fluorene and bithiophene co-polymers (F8T2). Also presented is the application of these polymers to an organic thin film transistor used as a biosensor. The side chains of fluorene were partially biotinylated after the esterification of the biotin with corresponding alcohol-groups at the side chain in F8T2. Their properties as an organic semiconductor were tested using an organic thin film transistor (OTFT) and were found to show typical p-type semiconductor curves. The functionality of this biosensor in the sensing of biologically active molecules such as avidin in comparison with bovine serum albumin (BSA) was established through a selective decrease in the conductivity of the transistor, as measured with a device that was developed by the authors. Changes to the optical properties of this polymer were also measured through the change in the color of the UV-fluorescence before and after a reaction with avidin or BSA.

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Schematic cross section of OTFT structures. (a) Bottom-contact and (b) Top-contact OTFT
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f2-sensors-12-11238: Schematic cross section of OTFT structures. (a) Bottom-contact and (b) Top-contact OTFT


Biotin-functionalized semiconducting polymer in an organic field effect transistor and application as a biosensor.

Kim ZS, Lim SC, Kim SH, Yang YS, Hwang DH - Sensors (Basel) (2012)

Schematic cross section of OTFT structures. (a) Bottom-contact and (b) Top-contact OTFT
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472882&req=5

f2-sensors-12-11238: Schematic cross section of OTFT structures. (a) Bottom-contact and (b) Top-contact OTFT
Bottom Line: The side chains of fluorene were partially biotinylated after the esterification of the biotin with corresponding alcohol-groups at the side chain in F8T2.The functionality of this biosensor in the sensing of biologically active molecules such as avidin in comparison with bovine serum albumin (BSA) was established through a selective decrease in the conductivity of the transistor, as measured with a device that was developed by the authors.Changes to the optical properties of this polymer were also measured through the change in the color of the UV-fluorescence before and after a reaction with avidin or BSA.

View Article: PubMed Central - PubMed

Affiliation: Electronics and Telecommunications Research Institute (ETRI), 218 Gajeongno, Yuseong-Gu, Daejeon 305-700, Korea. zinsig.kim@gmail.com

ABSTRACT
This report presents biotin-functionalized semiconducting polymers that are based on fluorene and bithiophene co-polymers (F8T2). Also presented is the application of these polymers to an organic thin film transistor used as a biosensor. The side chains of fluorene were partially biotinylated after the esterification of the biotin with corresponding alcohol-groups at the side chain in F8T2. Their properties as an organic semiconductor were tested using an organic thin film transistor (OTFT) and were found to show typical p-type semiconductor curves. The functionality of this biosensor in the sensing of biologically active molecules such as avidin in comparison with bovine serum albumin (BSA) was established through a selective decrease in the conductivity of the transistor, as measured with a device that was developed by the authors. Changes to the optical properties of this polymer were also measured through the change in the color of the UV-fluorescence before and after a reaction with avidin or BSA.

Show MeSH
Related in: MedlinePlus