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Fully integrated biochip platforms for advanced healthcare.

Carrara S, Ghoreishizadeh S, Olivo J, Taurino I, Baj-Rossi C, Cavallini A, de Beeck MO, Dehollain C, Burleson W, Moussy FG, Guiseppi-Elie A, De Micheli G - Sensors (Basel) (2012)

Bottom Line: However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices.Recent advances in the field have already proposed possible solutions for several of these issues.The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

View Article: PubMed Central - PubMed

Affiliation: École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. sandro.carrara@epfl.ch

ABSTRACT
Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

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Related in: MedlinePlus

Sensing principle of oxidases.
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f4-sensors-12-11013: Sensing principle of oxidases.

Mentions: In general, many oxidoreductases including glucose oxidase, catalyse the oxidation of substrates by electron transfer to oxygen to form hydrogen peroxide [14] (Figure 4). These oxidoreductase enzymes can be immobilized on conducting polymer surfaces and the H2O2 formed in the reaction is measured amperometrically [57]. The most commonly used enzymes in biosensing are glucose oxidase (GOx) [102] and horseradish peroxidase (HRP) [16]. Other, less commonly used enzymes comprise beta-lactamase [103], and urease [104].


Fully integrated biochip platforms for advanced healthcare.

Carrara S, Ghoreishizadeh S, Olivo J, Taurino I, Baj-Rossi C, Cavallini A, de Beeck MO, Dehollain C, Burleson W, Moussy FG, Guiseppi-Elie A, De Micheli G - Sensors (Basel) (2012)

Sensing principle of oxidases.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472872&req=5

f4-sensors-12-11013: Sensing principle of oxidases.
Mentions: In general, many oxidoreductases including glucose oxidase, catalyse the oxidation of substrates by electron transfer to oxygen to form hydrogen peroxide [14] (Figure 4). These oxidoreductase enzymes can be immobilized on conducting polymer surfaces and the H2O2 formed in the reaction is measured amperometrically [57]. The most commonly used enzymes in biosensing are glucose oxidase (GOx) [102] and horseradish peroxidase (HRP) [16]. Other, less commonly used enzymes comprise beta-lactamase [103], and urease [104].

Bottom Line: However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices.Recent advances in the field have already proposed possible solutions for several of these issues.The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

View Article: PubMed Central - PubMed

Affiliation: École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. sandro.carrara@epfl.ch

ABSTRACT
Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

Show MeSH
Related in: MedlinePlus