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Fully integrated biochip platforms for advanced healthcare.

Carrara S, Ghoreishizadeh S, Olivo J, Taurino I, Baj-Rossi C, Cavallini A, de Beeck MO, Dehollain C, Burleson W, Moussy FG, Guiseppi-Elie A, De Micheli G - Sensors (Basel) (2012)

Bottom Line: However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices.Recent advances in the field have already proposed possible solutions for several of these issues.The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

View Article: PubMed Central - PubMed

Affiliation: École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. sandro.carrara@epfl.ch

ABSTRACT
Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

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Related in: MedlinePlus

The i-needle under the skin, the remote-powering patch, and the mobile phone for connection to a geographical network.
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f19-sensors-12-11013: The i-needle under the skin, the remote-powering patch, and the mobile phone for connection to a geographical network.

Mentions: Platforms like that shown in Figure 17 require special co-design [254] of the supporting electronics circuitry for autonomous operations, as described in Section 5. So, a fully-integrated platform requires both an implanted device as well as a supporting external station for data receiving and power transmission, as schematically shown in Figure 18. The implantable device needs to have on board not only the detection front-end (Section 5) but also nano-materials to improve the sensors performance (Section 4), biomaterials providing the right specificity (Section 3), may be a bit of microfluidics and a biocompatible package (Section 7) is necessary as well as the remote powering system (Section 8). The supporting external station has to be located not far away for constraints coming from the physics of remote powering. A good solution that has been discussed in Section 8 is to have an electronic patch as light as possible just on top of the skin over the implant region, as shown in Figure 19. In that manner, a mobile phone network assures geographical connection to the hospitals or the healthcare services.


Fully integrated biochip platforms for advanced healthcare.

Carrara S, Ghoreishizadeh S, Olivo J, Taurino I, Baj-Rossi C, Cavallini A, de Beeck MO, Dehollain C, Burleson W, Moussy FG, Guiseppi-Elie A, De Micheli G - Sensors (Basel) (2012)

The i-needle under the skin, the remote-powering patch, and the mobile phone for connection to a geographical network.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472872&req=5

f19-sensors-12-11013: The i-needle under the skin, the remote-powering patch, and the mobile phone for connection to a geographical network.
Mentions: Platforms like that shown in Figure 17 require special co-design [254] of the supporting electronics circuitry for autonomous operations, as described in Section 5. So, a fully-integrated platform requires both an implanted device as well as a supporting external station for data receiving and power transmission, as schematically shown in Figure 18. The implantable device needs to have on board not only the detection front-end (Section 5) but also nano-materials to improve the sensors performance (Section 4), biomaterials providing the right specificity (Section 3), may be a bit of microfluidics and a biocompatible package (Section 7) is necessary as well as the remote powering system (Section 8). The supporting external station has to be located not far away for constraints coming from the physics of remote powering. A good solution that has been discussed in Section 8 is to have an electronic patch as light as possible just on top of the skin over the implant region, as shown in Figure 19. In that manner, a mobile phone network assures geographical connection to the hospitals or the healthcare services.

Bottom Line: However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices.Recent advances in the field have already proposed possible solutions for several of these issues.The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

View Article: PubMed Central - PubMed

Affiliation: École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. sandro.carrara@epfl.ch

ABSTRACT
Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

Show MeSH
Related in: MedlinePlus