Limits...
Fully integrated biochip platforms for advanced healthcare.

Carrara S, Ghoreishizadeh S, Olivo J, Taurino I, Baj-Rossi C, Cavallini A, de Beeck MO, Dehollain C, Burleson W, Moussy FG, Guiseppi-Elie A, De Micheli G - Sensors (Basel) (2012)

Bottom Line: However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices.Recent advances in the field have already proposed possible solutions for several of these issues.The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

View Article: PubMed Central - PubMed

Affiliation: École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. sandro.carrara@epfl.ch

ABSTRACT
Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

Show MeSH

Related in: MedlinePlus

Direct digital synthesizer (DDS) to generate a very slow ramp to drive a cyclic voltammetry measurement.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3472872&req=5

f12-sensors-12-11013: Direct digital synthesizer (DDS) to generate a very slow ramp to drive a cyclic voltammetry measurement.

Mentions: The potentiostat can be designed using one of many amplifiers in different configurations [190,191]. Depending on the type of the measurement, a fixed or a variable voltage is needed to apply to the cell. For single-target chronoamperometry, the voltage is fixed and chosen on the basis of the electrochemical reaction. For cyclic voltammetry, this circuit sweeps repeatedly within the voltage range of interest. A band-gap reference circuit can be used to generate a fixed voltage [192]. To design a very slow triangular waveform voltage, a mixed signal design approach can be used (Figure 12). In [186], a digitally programmable waveform generator was used by employing an up-down counter, comparator, latch and a digital to analog converter (DAC).


Fully integrated biochip platforms for advanced healthcare.

Carrara S, Ghoreishizadeh S, Olivo J, Taurino I, Baj-Rossi C, Cavallini A, de Beeck MO, Dehollain C, Burleson W, Moussy FG, Guiseppi-Elie A, De Micheli G - Sensors (Basel) (2012)

Direct digital synthesizer (DDS) to generate a very slow ramp to drive a cyclic voltammetry measurement.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472872&req=5

f12-sensors-12-11013: Direct digital synthesizer (DDS) to generate a very slow ramp to drive a cyclic voltammetry measurement.
Mentions: The potentiostat can be designed using one of many amplifiers in different configurations [190,191]. Depending on the type of the measurement, a fixed or a variable voltage is needed to apply to the cell. For single-target chronoamperometry, the voltage is fixed and chosen on the basis of the electrochemical reaction. For cyclic voltammetry, this circuit sweeps repeatedly within the voltage range of interest. A band-gap reference circuit can be used to generate a fixed voltage [192]. To design a very slow triangular waveform voltage, a mixed signal design approach can be used (Figure 12). In [186], a digitally programmable waveform generator was used by employing an up-down counter, comparator, latch and a digital to analog converter (DAC).

Bottom Line: However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices.Recent advances in the field have already proposed possible solutions for several of these issues.The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

View Article: PubMed Central - PubMed

Affiliation: École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. sandro.carrara@epfl.ch

ABSTRACT
Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

Show MeSH
Related in: MedlinePlus