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CMOS cell sensors for point-of-care diagnostics.

Adiguzel Y, Kulah H - Sensors (Basel) (2012)

Bottom Line: The burden of health-care related services in a global era with continuously increasing population and inefficient dissipation of the resources requires effective solutions.CMOS-based products can enable clinical tests in a fast, simple, safe, and reliable manner, with improved sensitivities.Portability due to diminished sensor dimensions and compactness of the test set-ups, along with low sample and power consumption, is another vital feature.

View Article: PubMed Central - PubMed

Affiliation: METU-MEMS Research and Application Center, Middle East Technical University, Ankara 06800, Turkey. yekbun@metu.edu.tr

ABSTRACT
The burden of health-care related services in a global era with continuously increasing population and inefficient dissipation of the resources requires effective solutions. From this perspective, point-of-care diagnostics is a demanded field in clinics. It is also necessary both for prompt diagnosis and for providing health services evenly throughout the population, including the rural districts. The requirements can only be fulfilled by technologies whose productivity has already been proven, such as complementary metal-oxide-semiconductors (CMOS). CMOS-based products can enable clinical tests in a fast, simple, safe, and reliable manner, with improved sensitivities. Portability due to diminished sensor dimensions and compactness of the test set-ups, along with low sample and power consumption, is another vital feature. CMOS-based sensors for cell studies have the potential to become essential counterparts of point-of-care diagnostics technologies. Hence, this review attempts to inform on the sensors fabricated with CMOS technology for point-of-care diagnostic studies, with a focus on CMOS image sensors and capacitance sensors for cell studies.

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Related in: MedlinePlus

Current paths in the integrated light source with an organic electroluminescence (EL) layer (a) and a GaInN LED array (b) [79]. Penetrating (single-pixel) current injection that is compatible with the light-emission structure can be achieved, once one of the electric pixel rows is chosen (a) [79]. In-plane (inter-pixel) current injection using two current injection lines at the same time can be realized, which is compatible with a light-emission structure that have a horizontal current flow (b) [79]. Reproduced from the Open Access publication Materials.
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f9-sensors-12-10042: Current paths in the integrated light source with an organic electroluminescence (EL) layer (a) and a GaInN LED array (b) [79]. Penetrating (single-pixel) current injection that is compatible with the light-emission structure can be achieved, once one of the electric pixel rows is chosen (a) [79]. In-plane (inter-pixel) current injection using two current injection lines at the same time can be realized, which is compatible with a light-emission structure that have a horizontal current flow (b) [79]. Reproduced from the Open Access publication Materials.

Mentions: A multifunctional CMOS image sensor for local current injection was described by Tokuda and co-workers [79] with a slight modification of the optical and electric multifunctional CMOS image sensor design, wherein they employed a random-access scheme for electric sensing pixel to be able to select electric pixels for current injection (Figure 9). The concept was developed as a multifunctional biointerface (neural-interface) device with a target field of application in brain/neural science [79].


CMOS cell sensors for point-of-care diagnostics.

Adiguzel Y, Kulah H - Sensors (Basel) (2012)

Current paths in the integrated light source with an organic electroluminescence (EL) layer (a) and a GaInN LED array (b) [79]. Penetrating (single-pixel) current injection that is compatible with the light-emission structure can be achieved, once one of the electric pixel rows is chosen (a) [79]. In-plane (inter-pixel) current injection using two current injection lines at the same time can be realized, which is compatible with a light-emission structure that have a horizontal current flow (b) [79]. Reproduced from the Open Access publication Materials.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472815&req=5

f9-sensors-12-10042: Current paths in the integrated light source with an organic electroluminescence (EL) layer (a) and a GaInN LED array (b) [79]. Penetrating (single-pixel) current injection that is compatible with the light-emission structure can be achieved, once one of the electric pixel rows is chosen (a) [79]. In-plane (inter-pixel) current injection using two current injection lines at the same time can be realized, which is compatible with a light-emission structure that have a horizontal current flow (b) [79]. Reproduced from the Open Access publication Materials.
Mentions: A multifunctional CMOS image sensor for local current injection was described by Tokuda and co-workers [79] with a slight modification of the optical and electric multifunctional CMOS image sensor design, wherein they employed a random-access scheme for electric sensing pixel to be able to select electric pixels for current injection (Figure 9). The concept was developed as a multifunctional biointerface (neural-interface) device with a target field of application in brain/neural science [79].

Bottom Line: The burden of health-care related services in a global era with continuously increasing population and inefficient dissipation of the resources requires effective solutions.CMOS-based products can enable clinical tests in a fast, simple, safe, and reliable manner, with improved sensitivities.Portability due to diminished sensor dimensions and compactness of the test set-ups, along with low sample and power consumption, is another vital feature.

View Article: PubMed Central - PubMed

Affiliation: METU-MEMS Research and Application Center, Middle East Technical University, Ankara 06800, Turkey. yekbun@metu.edu.tr

ABSTRACT
The burden of health-care related services in a global era with continuously increasing population and inefficient dissipation of the resources requires effective solutions. From this perspective, point-of-care diagnostics is a demanded field in clinics. It is also necessary both for prompt diagnosis and for providing health services evenly throughout the population, including the rural districts. The requirements can only be fulfilled by technologies whose productivity has already been proven, such as complementary metal-oxide-semiconductors (CMOS). CMOS-based products can enable clinical tests in a fast, simple, safe, and reliable manner, with improved sensitivities. Portability due to diminished sensor dimensions and compactness of the test set-ups, along with low sample and power consumption, is another vital feature. CMOS-based sensors for cell studies have the potential to become essential counterparts of point-of-care diagnostics technologies. Hence, this review attempts to inform on the sensors fabricated with CMOS technology for point-of-care diagnostic studies, with a focus on CMOS image sensors and capacitance sensors for cell studies.

Show MeSH
Related in: MedlinePlus