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CMOS cell sensors for point-of-care diagnostics.

Adiguzel Y, Kulah H - Sensors (Basel) (2012)

Bottom Line: The burden of health-care related services in a global era with continuously increasing population and inefficient dissipation of the resources requires effective solutions.CMOS-based products can enable clinical tests in a fast, simple, safe, and reliable manner, with improved sensitivities.Portability due to diminished sensor dimensions and compactness of the test set-ups, along with low sample and power consumption, is another vital feature.

View Article: PubMed Central - PubMed

Affiliation: METU-MEMS Research and Application Center, Middle East Technical University, Ankara 06800, Turkey. yekbun@metu.edu.tr

ABSTRACT
The burden of health-care related services in a global era with continuously increasing population and inefficient dissipation of the resources requires effective solutions. From this perspective, point-of-care diagnostics is a demanded field in clinics. It is also necessary both for prompt diagnosis and for providing health services evenly throughout the population, including the rural districts. The requirements can only be fulfilled by technologies whose productivity has already been proven, such as complementary metal-oxide-semiconductors (CMOS). CMOS-based products can enable clinical tests in a fast, simple, safe, and reliable manner, with improved sensitivities. Portability due to diminished sensor dimensions and compactness of the test set-ups, along with low sample and power consumption, is another vital feature. CMOS-based sensors for cell studies have the potential to become essential counterparts of point-of-care diagnostics technologies. Hence, this review attempts to inform on the sensors fabricated with CMOS technology for point-of-care diagnostic studies, with a focus on CMOS image sensors and capacitance sensors for cell studies.

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CMOS sensor (A) and microscopic (B) images of HeLa cells with no (A1 and B1) and with (A2 and B2) heat treatment following trypan blue staining [72]. Reproduced with the permission of Elsevier.
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f2-sensors-12-10042: CMOS sensor (A) and microscopic (B) images of HeLa cells with no (A1 and B1) and with (A2 and B2) heat treatment following trypan blue staining [72]. Reproduced with the permission of Elsevier.

Mentions: Despite the fact that the resolution of a contact imager is solely determined by its pixel size rather than the size of pixel array [71]; the detection range can be improved to a great extent by staining the cells. Chemiluminescence is also suitable for cell visualization with CMOS image sensors. In order to attain two dimensional (2D) imaging of mammalian cells by using a CMOS sensor at zero distance between the cell and sensor surface, Tanaka and co-workers [72] performed chemiluminescent imaging of HeLa cells with the CMOS sensor, along with cell staining. This was attained with 7.5 fps frame rate and by using a CMOS sensor. Living and dead cells were successfully distinguished by white- and blue-colored images using trypan blue staining of HeLa cells [72] (Figure 2). The ultimate aim was to develop a miniature cytometer for high throughput cell profiling. Zero-distance imaging by assembling individual cells on micro-lens array of the CMOS sensor was preferred for being advantageous in photon collection efficiency [73]. This brings about the suitability of CMOS sensor for real-time and high-content analysis of single cells.


CMOS cell sensors for point-of-care diagnostics.

Adiguzel Y, Kulah H - Sensors (Basel) (2012)

CMOS sensor (A) and microscopic (B) images of HeLa cells with no (A1 and B1) and with (A2 and B2) heat treatment following trypan blue staining [72]. Reproduced with the permission of Elsevier.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472815&req=5

f2-sensors-12-10042: CMOS sensor (A) and microscopic (B) images of HeLa cells with no (A1 and B1) and with (A2 and B2) heat treatment following trypan blue staining [72]. Reproduced with the permission of Elsevier.
Mentions: Despite the fact that the resolution of a contact imager is solely determined by its pixel size rather than the size of pixel array [71]; the detection range can be improved to a great extent by staining the cells. Chemiluminescence is also suitable for cell visualization with CMOS image sensors. In order to attain two dimensional (2D) imaging of mammalian cells by using a CMOS sensor at zero distance between the cell and sensor surface, Tanaka and co-workers [72] performed chemiluminescent imaging of HeLa cells with the CMOS sensor, along with cell staining. This was attained with 7.5 fps frame rate and by using a CMOS sensor. Living and dead cells were successfully distinguished by white- and blue-colored images using trypan blue staining of HeLa cells [72] (Figure 2). The ultimate aim was to develop a miniature cytometer for high throughput cell profiling. Zero-distance imaging by assembling individual cells on micro-lens array of the CMOS sensor was preferred for being advantageous in photon collection efficiency [73]. This brings about the suitability of CMOS sensor for real-time and high-content analysis of single cells.

Bottom Line: The burden of health-care related services in a global era with continuously increasing population and inefficient dissipation of the resources requires effective solutions.CMOS-based products can enable clinical tests in a fast, simple, safe, and reliable manner, with improved sensitivities.Portability due to diminished sensor dimensions and compactness of the test set-ups, along with low sample and power consumption, is another vital feature.

View Article: PubMed Central - PubMed

Affiliation: METU-MEMS Research and Application Center, Middle East Technical University, Ankara 06800, Turkey. yekbun@metu.edu.tr

ABSTRACT
The burden of health-care related services in a global era with continuously increasing population and inefficient dissipation of the resources requires effective solutions. From this perspective, point-of-care diagnostics is a demanded field in clinics. It is also necessary both for prompt diagnosis and for providing health services evenly throughout the population, including the rural districts. The requirements can only be fulfilled by technologies whose productivity has already been proven, such as complementary metal-oxide-semiconductors (CMOS). CMOS-based products can enable clinical tests in a fast, simple, safe, and reliable manner, with improved sensitivities. Portability due to diminished sensor dimensions and compactness of the test set-ups, along with low sample and power consumption, is another vital feature. CMOS-based sensors for cell studies have the potential to become essential counterparts of point-of-care diagnostics technologies. Hence, this review attempts to inform on the sensors fabricated with CMOS technology for point-of-care diagnostic studies, with a focus on CMOS image sensors and capacitance sensors for cell studies.

Show MeSH
Related in: MedlinePlus