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Protective effect of anthocyanin from Lonicera Caerulea var. Edulis on radiation-induced damage in mice.

Zhao H, Wang Z, Ma F, Yang X, Cheng C, Yao L - Int J Mol Sci (2012)

Bottom Line: Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05).Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups.These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.

View Article: PubMed Central - PubMed

Affiliation: School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China; E-Mails: zhaoht9999@163.com (H.Z.); mfm88492800@163.com (F.M.); yangxin940@163.com (X.Y.); luluyao2012@gmail.com (C.C.); yaoleiyl2000@163.com (L.Y.).

ABSTRACT
The radioprotective effect of anthocyanin extracted from Lonicera caerulea var. edulis (ALC), was studied in ICR mice. Different doses of ALC were intragastrically administered to mice once a day, prior to radiation. After two weeks, the mice received a one-time 5 Gy whole body (60)Coγ radiation. The spleen index, thymus index, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content, and glutathione (GSH) content in liver tissue were measured. Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05). Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups. These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.

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Effect of ALC on SOD activity (a), GSH-Px activity (b), GSH content (c) and MDA content (d) in liver tissue; Values= means ± SD, (n = 10) * p < 0.05 vs. NC group;#p < 0.05 vs. RC group.
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f2-ijms-13-11773: Effect of ALC on SOD activity (a), GSH-Px activity (b), GSH content (c) and MDA content (d) in liver tissue; Values= means ± SD, (n = 10) * p < 0.05 vs. NC group;#p < 0.05 vs. RC group.

Mentions: Effect of ALC on oxidant/antioxidant status in liver tissue of mice after 60Coγ radiation is shown in Figure 2. Compared with the radiation control, administration of ALC significantly increased activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in liver tissue (p < 0.05) in a dose-dependent manner. The malondialdehyde (MDA) levels in liver tissue were significantly decreased in all of the ALC-treated groups, compared with the radiation control group (p < 0.05). The glutathione (GSH) content also effectively increased in all ALC treated groups (p < 0.05); there was a trend toward improvement with ALC dose.


Protective effect of anthocyanin from Lonicera Caerulea var. Edulis on radiation-induced damage in mice.

Zhao H, Wang Z, Ma F, Yang X, Cheng C, Yao L - Int J Mol Sci (2012)

Effect of ALC on SOD activity (a), GSH-Px activity (b), GSH content (c) and MDA content (d) in liver tissue; Values= means ± SD, (n = 10) * p < 0.05 vs. NC group;#p < 0.05 vs. RC group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3472774&req=5

f2-ijms-13-11773: Effect of ALC on SOD activity (a), GSH-Px activity (b), GSH content (c) and MDA content (d) in liver tissue; Values= means ± SD, (n = 10) * p < 0.05 vs. NC group;#p < 0.05 vs. RC group.
Mentions: Effect of ALC on oxidant/antioxidant status in liver tissue of mice after 60Coγ radiation is shown in Figure 2. Compared with the radiation control, administration of ALC significantly increased activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in liver tissue (p < 0.05) in a dose-dependent manner. The malondialdehyde (MDA) levels in liver tissue were significantly decreased in all of the ALC-treated groups, compared with the radiation control group (p < 0.05). The glutathione (GSH) content also effectively increased in all ALC treated groups (p < 0.05); there was a trend toward improvement with ALC dose.

Bottom Line: Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05).Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups.These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.

View Article: PubMed Central - PubMed

Affiliation: School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China; E-Mails: zhaoht9999@163.com (H.Z.); mfm88492800@163.com (F.M.); yangxin940@163.com (X.Y.); luluyao2012@gmail.com (C.C.); yaoleiyl2000@163.com (L.Y.).

ABSTRACT
The radioprotective effect of anthocyanin extracted from Lonicera caerulea var. edulis (ALC), was studied in ICR mice. Different doses of ALC were intragastrically administered to mice once a day, prior to radiation. After two weeks, the mice received a one-time 5 Gy whole body (60)Coγ radiation. The spleen index, thymus index, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content, and glutathione (GSH) content in liver tissue were measured. Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05). Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups. These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.

Show MeSH
Related in: MedlinePlus