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Protective effect of anthocyanin from Lonicera Caerulea var. Edulis on radiation-induced damage in mice.

Zhao H, Wang Z, Ma F, Yang X, Cheng C, Yao L - Int J Mol Sci (2012)

Bottom Line: Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05).Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups.These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.

View Article: PubMed Central - PubMed

Affiliation: School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China; E-Mails: zhaoht9999@163.com (H.Z.); mfm88492800@163.com (F.M.); yangxin940@163.com (X.Y.); luluyao2012@gmail.com (C.C.); yaoleiyl2000@163.com (L.Y.).

ABSTRACT
The radioprotective effect of anthocyanin extracted from Lonicera caerulea var. edulis (ALC), was studied in ICR mice. Different doses of ALC were intragastrically administered to mice once a day, prior to radiation. After two weeks, the mice received a one-time 5 Gy whole body (60)Coγ radiation. The spleen index, thymus index, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content, and glutathione (GSH) content in liver tissue were measured. Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05). Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups. These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.

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Effect of ALC treatment on body weight change of mice; the ALC-1/2/3 groups were given ALC daily by intragastric administration based on dose of 50, 100, and 200 mg/kg body weight (b.w.) per day for 14 consecutive days.
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f1-ijms-13-11773: Effect of ALC treatment on body weight change of mice; the ALC-1/2/3 groups were given ALC daily by intragastric administration based on dose of 50, 100, and 200 mg/kg body weight (b.w.) per day for 14 consecutive days.

Mentions: All groups of mice increased body weight gradually with the time of feeding (Figure 1) and there were no significant differences in ALC treatment groups with normal control group (NC group).


Protective effect of anthocyanin from Lonicera Caerulea var. Edulis on radiation-induced damage in mice.

Zhao H, Wang Z, Ma F, Yang X, Cheng C, Yao L - Int J Mol Sci (2012)

Effect of ALC treatment on body weight change of mice; the ALC-1/2/3 groups were given ALC daily by intragastric administration based on dose of 50, 100, and 200 mg/kg body weight (b.w.) per day for 14 consecutive days.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3472774&req=5

f1-ijms-13-11773: Effect of ALC treatment on body weight change of mice; the ALC-1/2/3 groups were given ALC daily by intragastric administration based on dose of 50, 100, and 200 mg/kg body weight (b.w.) per day for 14 consecutive days.
Mentions: All groups of mice increased body weight gradually with the time of feeding (Figure 1) and there were no significant differences in ALC treatment groups with normal control group (NC group).

Bottom Line: Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05).Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups.These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.

View Article: PubMed Central - PubMed

Affiliation: School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China; E-Mails: zhaoht9999@163.com (H.Z.); mfm88492800@163.com (F.M.); yangxin940@163.com (X.Y.); luluyao2012@gmail.com (C.C.); yaoleiyl2000@163.com (L.Y.).

ABSTRACT
The radioprotective effect of anthocyanin extracted from Lonicera caerulea var. edulis (ALC), was studied in ICR mice. Different doses of ALC were intragastrically administered to mice once a day, prior to radiation. After two weeks, the mice received a one-time 5 Gy whole body (60)Coγ radiation. The spleen index, thymus index, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content, and glutathione (GSH) content in liver tissue were measured. Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05). Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups. These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.

Show MeSH