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Experimental aspects of colloidal interactions in mixed systems of liposome and inorganic nanoparticle and their applications.

Michel R, Gradzielski M - Int J Mol Sci (2012)

Bottom Line: Research on these systems has led to the observation of novel hybrid structures whose morphology strongly depends on the charge, composition and size of the interacting colloidal species as well as on the nature (pH, ionic strength) of their dispersing medium.A central role is played by the phase behaviour of phospholipid bilayers which have a tremendous influence on the liposome properties.Another central aspect is the incorporation of nanoparticles into vesicles, which is intimately linked to the conditions required for transporting a nanoparticle through a membrane.

View Article: PubMed Central - PubMed

Affiliation: Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, Berlin D-10623, Germany; E-Mails: raphael.michel@mailbox.tu-berlin.de (R.M.); michael.gradzielski@tu-berlin.de (M.G.); Tel.: +49-30-314-22822 (R.M.); +49-30-314-24934 (M.G.); M.G.).

ABSTRACT
In the past few years, growing attention has been devoted to the study of the interactions taking place in mixed systems of phospholipid membranes (for instance in the form of vesicles) and hard nanoparticles (NPs). In this context liposomes (vesicles) may serve as versatile carriers or as a model system for biological membranes. Research on these systems has led to the observation of novel hybrid structures whose morphology strongly depends on the charge, composition and size of the interacting colloidal species as well as on the nature (pH, ionic strength) of their dispersing medium. A central role is played by the phase behaviour of phospholipid bilayers which have a tremendous influence on the liposome properties. Another central aspect is the incorporation of nanoparticles into vesicles, which is intimately linked to the conditions required for transporting a nanoparticle through a membrane. Herein, we review recent progress made on the investigations of the interactions in liposome/nanoparticle systems focusing on the particularly interesting structures that are formed in these hybrid systems as well as their potential applications.

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Related in: MedlinePlus

Evolution of the hydrodynamic radius of dipalmitoylphosphatidylcholine (DPPC) vesicles (Rh ≈ 40 nm) decorated with different amount of silica NP (Rh ≈ 8 nm) in water for various ratios of nanoparticle per vesicle (experiment done at 25 °C).
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f6-ijms-13-11610: Evolution of the hydrodynamic radius of dipalmitoylphosphatidylcholine (DPPC) vesicles (Rh ≈ 40 nm) decorated with different amount of silica NP (Rh ≈ 8 nm) in water for various ratios of nanoparticle per vesicle (experiment done at 25 °C).

Mentions: This has similarly been observed in recent work by us as documented by the change of particle size as a function of time (Figure 6). This study on the stability of unilamellar DPPC vesicles (R ~ 50 nm) below their phase transition temperature by means of dynamic light scattering showed that the addition of small amounts of small silica NPs (Rh ≈ 8 nm) leads to a rapid destabilization of the vesicle dispersion [40]. Only the adsorption of a sufficiently high amount of silica particles onto the liposome surface, here about 14 NPs per vesicle, is able to prevent the fusion of neighbouring liposomes and ensure their colloidal stability for several months. This is an enormous enhancement compared to the situation of the unmodified vesicles and such long-time stability is very important for the storage of liposome dispersions and also for having controlled release properties.


Experimental aspects of colloidal interactions in mixed systems of liposome and inorganic nanoparticle and their applications.

Michel R, Gradzielski M - Int J Mol Sci (2012)

Evolution of the hydrodynamic radius of dipalmitoylphosphatidylcholine (DPPC) vesicles (Rh ≈ 40 nm) decorated with different amount of silica NP (Rh ≈ 8 nm) in water for various ratios of nanoparticle per vesicle (experiment done at 25 °C).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3472766&req=5

f6-ijms-13-11610: Evolution of the hydrodynamic radius of dipalmitoylphosphatidylcholine (DPPC) vesicles (Rh ≈ 40 nm) decorated with different amount of silica NP (Rh ≈ 8 nm) in water for various ratios of nanoparticle per vesicle (experiment done at 25 °C).
Mentions: This has similarly been observed in recent work by us as documented by the change of particle size as a function of time (Figure 6). This study on the stability of unilamellar DPPC vesicles (R ~ 50 nm) below their phase transition temperature by means of dynamic light scattering showed that the addition of small amounts of small silica NPs (Rh ≈ 8 nm) leads to a rapid destabilization of the vesicle dispersion [40]. Only the adsorption of a sufficiently high amount of silica particles onto the liposome surface, here about 14 NPs per vesicle, is able to prevent the fusion of neighbouring liposomes and ensure their colloidal stability for several months. This is an enormous enhancement compared to the situation of the unmodified vesicles and such long-time stability is very important for the storage of liposome dispersions and also for having controlled release properties.

Bottom Line: Research on these systems has led to the observation of novel hybrid structures whose morphology strongly depends on the charge, composition and size of the interacting colloidal species as well as on the nature (pH, ionic strength) of their dispersing medium.A central role is played by the phase behaviour of phospholipid bilayers which have a tremendous influence on the liposome properties.Another central aspect is the incorporation of nanoparticles into vesicles, which is intimately linked to the conditions required for transporting a nanoparticle through a membrane.

View Article: PubMed Central - PubMed

Affiliation: Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, Berlin D-10623, Germany; E-Mails: raphael.michel@mailbox.tu-berlin.de (R.M.); michael.gradzielski@tu-berlin.de (M.G.); Tel.: +49-30-314-22822 (R.M.); +49-30-314-24934 (M.G.); M.G.).

ABSTRACT
In the past few years, growing attention has been devoted to the study of the interactions taking place in mixed systems of phospholipid membranes (for instance in the form of vesicles) and hard nanoparticles (NPs). In this context liposomes (vesicles) may serve as versatile carriers or as a model system for biological membranes. Research on these systems has led to the observation of novel hybrid structures whose morphology strongly depends on the charge, composition and size of the interacting colloidal species as well as on the nature (pH, ionic strength) of their dispersing medium. A central role is played by the phase behaviour of phospholipid bilayers which have a tremendous influence on the liposome properties. Another central aspect is the incorporation of nanoparticles into vesicles, which is intimately linked to the conditions required for transporting a nanoparticle through a membrane. Herein, we review recent progress made on the investigations of the interactions in liposome/nanoparticle systems focusing on the particularly interesting structures that are formed in these hybrid systems as well as their potential applications.

Show MeSH
Related in: MedlinePlus