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Experimental aspects of colloidal interactions in mixed systems of liposome and inorganic nanoparticle and their applications.

Michel R, Gradzielski M - Int J Mol Sci (2012)

Bottom Line: Research on these systems has led to the observation of novel hybrid structures whose morphology strongly depends on the charge, composition and size of the interacting colloidal species as well as on the nature (pH, ionic strength) of their dispersing medium.A central role is played by the phase behaviour of phospholipid bilayers which have a tremendous influence on the liposome properties.Another central aspect is the incorporation of nanoparticles into vesicles, which is intimately linked to the conditions required for transporting a nanoparticle through a membrane.

View Article: PubMed Central - PubMed

Affiliation: Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, Berlin D-10623, Germany; E-Mails: raphael.michel@mailbox.tu-berlin.de (R.M.); michael.gradzielski@tu-berlin.de (M.G.); Tel.: +49-30-314-22822 (R.M.); +49-30-314-24934 (M.G.); M.G.).

ABSTRACT
In the past few years, growing attention has been devoted to the study of the interactions taking place in mixed systems of phospholipid membranes (for instance in the form of vesicles) and hard nanoparticles (NPs). In this context liposomes (vesicles) may serve as versatile carriers or as a model system for biological membranes. Research on these systems has led to the observation of novel hybrid structures whose morphology strongly depends on the charge, composition and size of the interacting colloidal species as well as on the nature (pH, ionic strength) of their dispersing medium. A central role is played by the phase behaviour of phospholipid bilayers which have a tremendous influence on the liposome properties. Another central aspect is the incorporation of nanoparticles into vesicles, which is intimately linked to the conditions required for transporting a nanoparticle through a membrane. Herein, we review recent progress made on the investigations of the interactions in liposome/nanoparticle systems focusing on the particularly interesting structures that are formed in these hybrid systems as well as their potential applications.

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Related in: MedlinePlus

Schematic drawings of the possible mechanisms occurring in the mixed systems liposome/nanoparticle in the case of hydrophilic particles and fluid state liposomes, assuming sufficiently high attractive interactions between membranes and nanoparticles.
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f2-ijms-13-11610: Schematic drawings of the possible mechanisms occurring in the mixed systems liposome/nanoparticle in the case of hydrophilic particles and fluid state liposomes, assuming sufficiently high attractive interactions between membranes and nanoparticles.

Mentions: Changing the ionic strength and/or the pH is a way to alter the electrostatic properties of the substrate as well as the phospholipid net charge leading to different adsorption behaviors depending on the nature of the substrate and on the type of lipid used [52,75,84,85]. More precisely, the use of specific ions (in particular divalent cations) has been found to have a surprisingly strong effect on SLB formation, when bridging negatively charged or zwitterionic lipids and negatively charged substrates (silica-Figure 1) [79,86–89]. This is not surprising given the known affinity of Ca2+ and phosphate. The case of zwitterionic phospholipids is particularly interesting, as the cations convert the headgroup from a dipole toward a positive monopole thus strengthening the interaction with negatively charged substrate (Figure 2) [85,88].


Experimental aspects of colloidal interactions in mixed systems of liposome and inorganic nanoparticle and their applications.

Michel R, Gradzielski M - Int J Mol Sci (2012)

Schematic drawings of the possible mechanisms occurring in the mixed systems liposome/nanoparticle in the case of hydrophilic particles and fluid state liposomes, assuming sufficiently high attractive interactions between membranes and nanoparticles.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3472766&req=5

f2-ijms-13-11610: Schematic drawings of the possible mechanisms occurring in the mixed systems liposome/nanoparticle in the case of hydrophilic particles and fluid state liposomes, assuming sufficiently high attractive interactions between membranes and nanoparticles.
Mentions: Changing the ionic strength and/or the pH is a way to alter the electrostatic properties of the substrate as well as the phospholipid net charge leading to different adsorption behaviors depending on the nature of the substrate and on the type of lipid used [52,75,84,85]. More precisely, the use of specific ions (in particular divalent cations) has been found to have a surprisingly strong effect on SLB formation, when bridging negatively charged or zwitterionic lipids and negatively charged substrates (silica-Figure 1) [79,86–89]. This is not surprising given the known affinity of Ca2+ and phosphate. The case of zwitterionic phospholipids is particularly interesting, as the cations convert the headgroup from a dipole toward a positive monopole thus strengthening the interaction with negatively charged substrate (Figure 2) [85,88].

Bottom Line: Research on these systems has led to the observation of novel hybrid structures whose morphology strongly depends on the charge, composition and size of the interacting colloidal species as well as on the nature (pH, ionic strength) of their dispersing medium.A central role is played by the phase behaviour of phospholipid bilayers which have a tremendous influence on the liposome properties.Another central aspect is the incorporation of nanoparticles into vesicles, which is intimately linked to the conditions required for transporting a nanoparticle through a membrane.

View Article: PubMed Central - PubMed

Affiliation: Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, Berlin D-10623, Germany; E-Mails: raphael.michel@mailbox.tu-berlin.de (R.M.); michael.gradzielski@tu-berlin.de (M.G.); Tel.: +49-30-314-22822 (R.M.); +49-30-314-24934 (M.G.); M.G.).

ABSTRACT
In the past few years, growing attention has been devoted to the study of the interactions taking place in mixed systems of phospholipid membranes (for instance in the form of vesicles) and hard nanoparticles (NPs). In this context liposomes (vesicles) may serve as versatile carriers or as a model system for biological membranes. Research on these systems has led to the observation of novel hybrid structures whose morphology strongly depends on the charge, composition and size of the interacting colloidal species as well as on the nature (pH, ionic strength) of their dispersing medium. A central role is played by the phase behaviour of phospholipid bilayers which have a tremendous influence on the liposome properties. Another central aspect is the incorporation of nanoparticles into vesicles, which is intimately linked to the conditions required for transporting a nanoparticle through a membrane. Herein, we review recent progress made on the investigations of the interactions in liposome/nanoparticle systems focusing on the particularly interesting structures that are formed in these hybrid systems as well as their potential applications.

Show MeSH
Related in: MedlinePlus