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New 14-membered cyclopeptide alkaloids from Zizyphus oxyphylla Edgew.

Kaleem WA, Nisar M, Qayum M, Zia-Ul-Haq M, Adhikari A, De Feo V - Int J Mol Sci (2012)

Bottom Line: Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew.The compounds were tested for antibacterial activity.Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 μg/mL) than other compounds.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Abdul Wali Khan University Mardan, Anbar Campus 23200, Pakistan; E-Mail: waqar679@yahoo.co.uk.

ABSTRACT
Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 μg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 μg/mL), Pseudomonas aeruginosa (MIC, 50 μg/mL) and Salmonella typhi (MIC, 50 μg/mL).

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Isolated cyclopeptides (1–5).
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f1-ijms-13-11520: Isolated cyclopeptides (1–5).

Mentions: Chloroform fraction of the methanolic extract of Z. oxyphylla stem was subjected to multiple chromatographic steps involving column chromatography and preparative TLC. This process yielded two new cyclopeptide alkaloids (3,4,5) and from the dichloromethane fraction of root, two cyclopeptide alkaloids (1 and 2) were isolated as white amorphous powders (Figure 1). Structures of the known compounds (1–3) were elucidated by comparing their analytical data with literature values [6,8–11].


New 14-membered cyclopeptide alkaloids from Zizyphus oxyphylla Edgew.

Kaleem WA, Nisar M, Qayum M, Zia-Ul-Haq M, Adhikari A, De Feo V - Int J Mol Sci (2012)

Isolated cyclopeptides (1–5).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3472760&req=5

f1-ijms-13-11520: Isolated cyclopeptides (1–5).
Mentions: Chloroform fraction of the methanolic extract of Z. oxyphylla stem was subjected to multiple chromatographic steps involving column chromatography and preparative TLC. This process yielded two new cyclopeptide alkaloids (3,4,5) and from the dichloromethane fraction of root, two cyclopeptide alkaloids (1 and 2) were isolated as white amorphous powders (Figure 1). Structures of the known compounds (1–3) were elucidated by comparing their analytical data with literature values [6,8–11].

Bottom Line: Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew.The compounds were tested for antibacterial activity.Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 μg/mL) than other compounds.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Abdul Wali Khan University Mardan, Anbar Campus 23200, Pakistan; E-Mail: waqar679@yahoo.co.uk.

ABSTRACT
Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 μg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 μg/mL), Pseudomonas aeruginosa (MIC, 50 μg/mL) and Salmonella typhi (MIC, 50 μg/mL).

Show MeSH
Related in: MedlinePlus