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Ultrasound-assisted extraction of carnosic acid and rosmarinic acid using ionic liquid solution from Rosmarinus officinalis.

Zu G, Zhang R, Yang L, Ma C, Zu Y, Wang W, Zhao C - Int J Mol Sci (2012)

Bottom Line: Ionic liquid based, ultrasound-assisted extraction was successfully applied to the extraction of phenolcarboxylic acids, carnosic acid and rosmarinic acid, from Rosmarinus officinalis.Ultrasound extraction parameters, including soaking time, solid-liquid ratio, ultrasound power and time, and the number of extraction cycles, were discussed by single factor experiments and the main influence factors were optimized by response surface methodology.The proposed approach was demonstrated as having higher efficiency, shorter extraction time and as a new alternative for the extraction of carnosic acid and rosmarinic acid from R. officinalis compared with traditional reference extraction methods.

View Article: PubMed Central - PubMed

Affiliation: State Engineering Laboratory for Bioresource Eco-Utilization, Northeast Forestry University, Harbin 150040, China; E-Mails: zygenefu@163.com (G.Z.); zhangrongrui1986@126.com (R.Z.); mchmchmchmch@163.com (C.M.); wjwang225@hotmail.com (W.W.); zcjsj@163.com (C.Z.).

ABSTRACT
Ionic liquid based, ultrasound-assisted extraction was successfully applied to the extraction of phenolcarboxylic acids, carnosic acid and rosmarinic acid, from Rosmarinus officinalis. Eight ionic liquids, with different cations and anions, were investigated in this work and [C(8)mim]Br was selected as the optimal solvent. Ultrasound extraction parameters, including soaking time, solid-liquid ratio, ultrasound power and time, and the number of extraction cycles, were discussed by single factor experiments and the main influence factors were optimized by response surface methodology. The proposed approach was demonstrated as having higher efficiency, shorter extraction time and as a new alternative for the extraction of carnosic acid and rosmarinic acid from R. officinalis compared with traditional reference extraction methods. Ionic liquids are considered to be green solvents, in the ultrasound-assisted extraction of key chemicals from medicinal plants, and show great potential.

Show MeSH
Effects of ionic liquids anion (a) the alkyl chain length of cation; (b) and ionic liquid concentration; (c) on the extraction efficiency of target compounds. The extraction efficiency is expressed as the observed values of target analytes and the maximum amount in each curve was taken to be 100%.
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f1-ijms-13-11027: Effects of ionic liquids anion (a) the alkyl chain length of cation; (b) and ionic liquid concentration; (c) on the extraction efficiency of target compounds. The extraction efficiency is expressed as the observed values of target analytes and the maximum amount in each curve was taken to be 100%.

Mentions: The results obtained are given in Figure 1a. The ionic liquids based on Cl− and Br − were the most efficient of the liquids tested for carnosic acid; BF4− and Br− were the most efficient for rosmarinic acid, with Br− showing the best results. This result indicates that extraction efficiency of phenolcarboxylic acids is anion-dependent, which is consistent with a previous study [25].


Ultrasound-assisted extraction of carnosic acid and rosmarinic acid using ionic liquid solution from Rosmarinus officinalis.

Zu G, Zhang R, Yang L, Ma C, Zu Y, Wang W, Zhao C - Int J Mol Sci (2012)

Effects of ionic liquids anion (a) the alkyl chain length of cation; (b) and ionic liquid concentration; (c) on the extraction efficiency of target compounds. The extraction efficiency is expressed as the observed values of target analytes and the maximum amount in each curve was taken to be 100%.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3472728&req=5

f1-ijms-13-11027: Effects of ionic liquids anion (a) the alkyl chain length of cation; (b) and ionic liquid concentration; (c) on the extraction efficiency of target compounds. The extraction efficiency is expressed as the observed values of target analytes and the maximum amount in each curve was taken to be 100%.
Mentions: The results obtained are given in Figure 1a. The ionic liquids based on Cl− and Br − were the most efficient of the liquids tested for carnosic acid; BF4− and Br− were the most efficient for rosmarinic acid, with Br− showing the best results. This result indicates that extraction efficiency of phenolcarboxylic acids is anion-dependent, which is consistent with a previous study [25].

Bottom Line: Ionic liquid based, ultrasound-assisted extraction was successfully applied to the extraction of phenolcarboxylic acids, carnosic acid and rosmarinic acid, from Rosmarinus officinalis.Ultrasound extraction parameters, including soaking time, solid-liquid ratio, ultrasound power and time, and the number of extraction cycles, were discussed by single factor experiments and the main influence factors were optimized by response surface methodology.The proposed approach was demonstrated as having higher efficiency, shorter extraction time and as a new alternative for the extraction of carnosic acid and rosmarinic acid from R. officinalis compared with traditional reference extraction methods.

View Article: PubMed Central - PubMed

Affiliation: State Engineering Laboratory for Bioresource Eco-Utilization, Northeast Forestry University, Harbin 150040, China; E-Mails: zygenefu@163.com (G.Z.); zhangrongrui1986@126.com (R.Z.); mchmchmchmch@163.com (C.M.); wjwang225@hotmail.com (W.W.); zcjsj@163.com (C.Z.).

ABSTRACT
Ionic liquid based, ultrasound-assisted extraction was successfully applied to the extraction of phenolcarboxylic acids, carnosic acid and rosmarinic acid, from Rosmarinus officinalis. Eight ionic liquids, with different cations and anions, were investigated in this work and [C(8)mim]Br was selected as the optimal solvent. Ultrasound extraction parameters, including soaking time, solid-liquid ratio, ultrasound power and time, and the number of extraction cycles, were discussed by single factor experiments and the main influence factors were optimized by response surface methodology. The proposed approach was demonstrated as having higher efficiency, shorter extraction time and as a new alternative for the extraction of carnosic acid and rosmarinic acid from R. officinalis compared with traditional reference extraction methods. Ionic liquids are considered to be green solvents, in the ultrasound-assisted extraction of key chemicals from medicinal plants, and show great potential.

Show MeSH