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Prenatal vitamin D deficiency induces an early and more severe experimental autoimmune encephalomyelitis in the second generation.

Fernandes de Abreu DA, Landel V, Barnett AG, McGrath J, Eyles D, Feron F - Int J Mol Sci (2012)

Bottom Line: We then wondered whether a similar response was observed in the subsequent generation.A trend for a reduced number of births in the Fall for the parents of MS patients was observed but statistical significance was not reached.Further well powered studies are warranted to validate the latter finding.

View Article: PubMed Central - PubMed

Affiliation: Neurobiology of Cell Interactions and Neurophysiopathology, Centre National de la Recherche Scientifique, UMR 7259, Aix Marseille Université, Marseille 13015, France; E-Mails: diana.fernandes_de_abreu@kcl.ac.uk (D.A.F.A.); verena.landel@univ-amu.fr (V.L.).

ABSTRACT
In a previous study, we demonstrated that mouse adult F(1) offspring, exposed to a vitamin D deficiency during pregnancy, developed a less severe and delayed Experimental Autoimmune Encephalomyelitis (EAE), when compared with control offspring. We then wondered whether a similar response was observed in the subsequent generation. To answer this question, we assessed F(2) females whose F(1) parents (males or females) were vitamin D-deprived when developing in the uterus of F(0) females. Unexpectedly, we observed that the vitamin D deficiency affecting the F(0) pregnant mice induced a precocious and more severe EAE in the F(2) generation. This paradoxical finding led us to assess its implications for the epidemiology of Multiple Sclerosis (MS) in humans. Using the REFGENSEP database for MS trios (the patient and his/her parents), we collected the parents' dates of birth and assessed a potential season of birth effect that could potentially be indicative of the vitamin D status of the pregnant grandmothers. A trend for a reduced number of births in the Fall for the parents of MS patients was observed but statistical significance was not reached. Further well powered studies are warranted to validate the latter finding.

No MeSH data available.


Related in: MedlinePlus

Pooled analysis of observed/expected births in parents of MS patients (n = 610 per group). The decreased number of births in the Fall is not statistically significant.
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f3-ijms-13-10911: Pooled analysis of observed/expected births in parents of MS patients (n = 610 per group). The decreased number of births in the Fall is not statistically significant.

Mentions: Parents’ dates of births were clustered into seasons as follows: Winter (December, January, February), Spring (March, April, May), Summer (June, July, August) and the Fall (September, October, November). Figure 3 indicates that the lowest risk for both groups is consistently in the Fall, although this pattern was not statistically significant (p-values: 0.28 mothers, 0.25 fathers).


Prenatal vitamin D deficiency induces an early and more severe experimental autoimmune encephalomyelitis in the second generation.

Fernandes de Abreu DA, Landel V, Barnett AG, McGrath J, Eyles D, Feron F - Int J Mol Sci (2012)

Pooled analysis of observed/expected births in parents of MS patients (n = 610 per group). The decreased number of births in the Fall is not statistically significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3472720&req=5

f3-ijms-13-10911: Pooled analysis of observed/expected births in parents of MS patients (n = 610 per group). The decreased number of births in the Fall is not statistically significant.
Mentions: Parents’ dates of births were clustered into seasons as follows: Winter (December, January, February), Spring (March, April, May), Summer (June, July, August) and the Fall (September, October, November). Figure 3 indicates that the lowest risk for both groups is consistently in the Fall, although this pattern was not statistically significant (p-values: 0.28 mothers, 0.25 fathers).

Bottom Line: We then wondered whether a similar response was observed in the subsequent generation.A trend for a reduced number of births in the Fall for the parents of MS patients was observed but statistical significance was not reached.Further well powered studies are warranted to validate the latter finding.

View Article: PubMed Central - PubMed

Affiliation: Neurobiology of Cell Interactions and Neurophysiopathology, Centre National de la Recherche Scientifique, UMR 7259, Aix Marseille Université, Marseille 13015, France; E-Mails: diana.fernandes_de_abreu@kcl.ac.uk (D.A.F.A.); verena.landel@univ-amu.fr (V.L.).

ABSTRACT
In a previous study, we demonstrated that mouse adult F(1) offspring, exposed to a vitamin D deficiency during pregnancy, developed a less severe and delayed Experimental Autoimmune Encephalomyelitis (EAE), when compared with control offspring. We then wondered whether a similar response was observed in the subsequent generation. To answer this question, we assessed F(2) females whose F(1) parents (males or females) were vitamin D-deprived when developing in the uterus of F(0) females. Unexpectedly, we observed that the vitamin D deficiency affecting the F(0) pregnant mice induced a precocious and more severe EAE in the F(2) generation. This paradoxical finding led us to assess its implications for the epidemiology of Multiple Sclerosis (MS) in humans. Using the REFGENSEP database for MS trios (the patient and his/her parents), we collected the parents' dates of birth and assessed a potential season of birth effect that could potentially be indicative of the vitamin D status of the pregnant grandmothers. A trend for a reduced number of births in the Fall for the parents of MS patients was observed but statistical significance was not reached. Further well powered studies are warranted to validate the latter finding.

No MeSH data available.


Related in: MedlinePlus