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Adaptive response, evidence of cross-resistance and its potential clinical use.

Milisav I, Poljsak B, Suput D - Int J Mol Sci (2012)

Bottom Line: Stress responses are mechanisms used by organisms to adapt to and overcome stress stimuli.Studies have reported life-prolonging effects of a wide variety of so-called stressors, such as oxidants, heat shock, some phytochemicals, ischemia, exercise and dietary energy restriction, hypergravity, etc.These stress responses, which result in enhanced defense and repair and even cross-resistance against multiple stressors, may have clinical use and will be discussed, while the emphasis will be on the effects/cross-effects of oxidants.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska 4, Ljubljana SI-1000, Slovenia; E-Mail: dusan.suput@mf.uni-lj.si ; Faculty of Health Sciences, University of Ljubljana, Zdravstvena pot 5, Ljubljana SI-1000, Slovenia; E-Mail: borut.poljsak@zf.uni-lj.si.

ABSTRACT
Organisms and their cells are constantly exposed to environmental fluctuations. Among them are stressors, which can induce macromolecular damage that exceeds a set threshold, independent of the underlying cause. Stress responses are mechanisms used by organisms to adapt to and overcome stress stimuli. Different stressors or different intensities of stress trigger different cellular responses, namely induce cell repair mechanisms, induce cell responses that result in temporary adaptation to some stressors, induce autophagy or trigger cell death. Studies have reported life-prolonging effects of a wide variety of so-called stressors, such as oxidants, heat shock, some phytochemicals, ischemia, exercise and dietary energy restriction, hypergravity, etc. These stress responses, which result in enhanced defense and repair and even cross-resistance against multiple stressors, may have clinical use and will be discussed, while the emphasis will be on the effects/cross-effects of oxidants.

No MeSH data available.


Related in: MedlinePlus

Adaptive stress response. Stress responses are mechanisms to adapt to and to overcome stress stimuli. Through them, the cells can restore stress-damaged structures or trigger cell death. Stress responses to mild/moderate stress may result in enhanced defense and repair and even cross-resistance to multiple stressors. This state is called adaptive stress response and it is achieved through multiple mechanisms, including modulation of apoptosis triggering [5], damage repair [14] and synthesis of protective molecules [2]. The solid line arrows point to the positive outcome, the dotted-line arrows to the negative one.
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f1-ijms-13-10771: Adaptive stress response. Stress responses are mechanisms to adapt to and to overcome stress stimuli. Through them, the cells can restore stress-damaged structures or trigger cell death. Stress responses to mild/moderate stress may result in enhanced defense and repair and even cross-resistance to multiple stressors. This state is called adaptive stress response and it is achieved through multiple mechanisms, including modulation of apoptosis triggering [5], damage repair [14] and synthesis of protective molecules [2]. The solid line arrows point to the positive outcome, the dotted-line arrows to the negative one.

Mentions: Many proteins involved in decisions of life and death are likely to play a part in adaptation to stress, since it is often the intensity and duration of the stress trigger that determines whether the cells can adapt to the stress or whether they will die as the result of it [3,14]. Also, any stressor will likely cause some damage to cellular structures, which will be removed and repaired. The cells may increase the synthesis of protective molecules, as is well established during oxidative stress (Figure 1).


Adaptive response, evidence of cross-resistance and its potential clinical use.

Milisav I, Poljsak B, Suput D - Int J Mol Sci (2012)

Adaptive stress response. Stress responses are mechanisms to adapt to and to overcome stress stimuli. Through them, the cells can restore stress-damaged structures or trigger cell death. Stress responses to mild/moderate stress may result in enhanced defense and repair and even cross-resistance to multiple stressors. This state is called adaptive stress response and it is achieved through multiple mechanisms, including modulation of apoptosis triggering [5], damage repair [14] and synthesis of protective molecules [2]. The solid line arrows point to the positive outcome, the dotted-line arrows to the negative one.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3472714&req=5

f1-ijms-13-10771: Adaptive stress response. Stress responses are mechanisms to adapt to and to overcome stress stimuli. Through them, the cells can restore stress-damaged structures or trigger cell death. Stress responses to mild/moderate stress may result in enhanced defense and repair and even cross-resistance to multiple stressors. This state is called adaptive stress response and it is achieved through multiple mechanisms, including modulation of apoptosis triggering [5], damage repair [14] and synthesis of protective molecules [2]. The solid line arrows point to the positive outcome, the dotted-line arrows to the negative one.
Mentions: Many proteins involved in decisions of life and death are likely to play a part in adaptation to stress, since it is often the intensity and duration of the stress trigger that determines whether the cells can adapt to the stress or whether they will die as the result of it [3,14]. Also, any stressor will likely cause some damage to cellular structures, which will be removed and repaired. The cells may increase the synthesis of protective molecules, as is well established during oxidative stress (Figure 1).

Bottom Line: Stress responses are mechanisms used by organisms to adapt to and overcome stress stimuli.Studies have reported life-prolonging effects of a wide variety of so-called stressors, such as oxidants, heat shock, some phytochemicals, ischemia, exercise and dietary energy restriction, hypergravity, etc.These stress responses, which result in enhanced defense and repair and even cross-resistance against multiple stressors, may have clinical use and will be discussed, while the emphasis will be on the effects/cross-effects of oxidants.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska 4, Ljubljana SI-1000, Slovenia; E-Mail: dusan.suput@mf.uni-lj.si ; Faculty of Health Sciences, University of Ljubljana, Zdravstvena pot 5, Ljubljana SI-1000, Slovenia; E-Mail: borut.poljsak@zf.uni-lj.si.

ABSTRACT
Organisms and their cells are constantly exposed to environmental fluctuations. Among them are stressors, which can induce macromolecular damage that exceeds a set threshold, independent of the underlying cause. Stress responses are mechanisms used by organisms to adapt to and overcome stress stimuli. Different stressors or different intensities of stress trigger different cellular responses, namely induce cell repair mechanisms, induce cell responses that result in temporary adaptation to some stressors, induce autophagy or trigger cell death. Studies have reported life-prolonging effects of a wide variety of so-called stressors, such as oxidants, heat shock, some phytochemicals, ischemia, exercise and dietary energy restriction, hypergravity, etc. These stress responses, which result in enhanced defense and repair and even cross-resistance against multiple stressors, may have clinical use and will be discussed, while the emphasis will be on the effects/cross-effects of oxidants.

No MeSH data available.


Related in: MedlinePlus