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Embryologic Association of Tornwaldt's Cyst with Cerebral Artery Abnormalities and Infarction: A Case Report.

Osborn MF, Buchanan BK, Akle N, Badr A, Zhang J - Case Rep Pediatr (2012)

Bottom Line: Summary of Case.Conclusions.This paper suggests an etiologic connection between Tornwaldt's cysts and cerebral vasculature abnormalities by way of notochordal dysfunction during development, likely the result of perturbation of notochord-derived molecular cues during development or biogenesis.

View Article: PubMed Central - PubMed

Affiliation: COE in Neurosciences and Departments of Anesthesiology and Biomedical Sciences, Texas Tech University Health Science Center, El Paso, TX 79905, USA.

ABSTRACT
Background and Purpose. Tornwaldt's cysts are rare nasopharyngeal lesions that develop from remnants of the embryonic notochord. Summary of Case. We reported a twelve-year-old female stroke patient with Tornwaldt's cysts, whose father also suffered a stroke at age fifty two with the presence of an abdominal aortic aneurysm, suggesting a genetic influence in this case. Conclusions. This paper suggests an etiologic connection between Tornwaldt's cysts and cerebral vasculature abnormalities by way of notochordal dysfunction during development, likely the result of perturbation of notochord-derived molecular cues during development or biogenesis.

No MeSH data available.


Related in: MedlinePlus

Depiction of a cross section through the early embryo demonstrating the relationship between the neural tube (A), notochord (B), dorsal aortae (C), and gut tube (D).
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fig1: Depiction of a cross section through the early embryo demonstrating the relationship between the neural tube (A), notochord (B), dorsal aortae (C), and gut tube (D).

Mentions: In addition to the proximity to both the gut and neural tube, the notochord is in close proximity to the developing vasculature, most notably the dorsal aortae. The dorsal aortae are two large vessels that run the length of the embryo [9]. These vessels lie on either side and slightly ventral to the notochord, and dorsal to the gut tube (Figure 1) [9]. The cranial extensions of the dorsal aortae form the distal portions of the internal carotid artery including the middle cerebral arteries [10]. In addition to these cranial vessels, the dorsal aortae fuse to form the descending aorta [10].


Embryologic Association of Tornwaldt's Cyst with Cerebral Artery Abnormalities and Infarction: A Case Report.

Osborn MF, Buchanan BK, Akle N, Badr A, Zhang J - Case Rep Pediatr (2012)

Depiction of a cross section through the early embryo demonstrating the relationship between the neural tube (A), notochord (B), dorsal aortae (C), and gut tube (D).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472527&req=5

fig1: Depiction of a cross section through the early embryo demonstrating the relationship between the neural tube (A), notochord (B), dorsal aortae (C), and gut tube (D).
Mentions: In addition to the proximity to both the gut and neural tube, the notochord is in close proximity to the developing vasculature, most notably the dorsal aortae. The dorsal aortae are two large vessels that run the length of the embryo [9]. These vessels lie on either side and slightly ventral to the notochord, and dorsal to the gut tube (Figure 1) [9]. The cranial extensions of the dorsal aortae form the distal portions of the internal carotid artery including the middle cerebral arteries [10]. In addition to these cranial vessels, the dorsal aortae fuse to form the descending aorta [10].

Bottom Line: Summary of Case.Conclusions.This paper suggests an etiologic connection between Tornwaldt's cysts and cerebral vasculature abnormalities by way of notochordal dysfunction during development, likely the result of perturbation of notochord-derived molecular cues during development or biogenesis.

View Article: PubMed Central - PubMed

Affiliation: COE in Neurosciences and Departments of Anesthesiology and Biomedical Sciences, Texas Tech University Health Science Center, El Paso, TX 79905, USA.

ABSTRACT
Background and Purpose. Tornwaldt's cysts are rare nasopharyngeal lesions that develop from remnants of the embryonic notochord. Summary of Case. We reported a twelve-year-old female stroke patient with Tornwaldt's cysts, whose father also suffered a stroke at age fifty two with the presence of an abdominal aortic aneurysm, suggesting a genetic influence in this case. Conclusions. This paper suggests an etiologic connection between Tornwaldt's cysts and cerebral vasculature abnormalities by way of notochordal dysfunction during development, likely the result of perturbation of notochord-derived molecular cues during development or biogenesis.

No MeSH data available.


Related in: MedlinePlus