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Stereotactic body radiotherapy for metastatic lung cancer as oligo-recurrence: an analysis of 42 cases.

Takahashi W, Yamashita H, Niibe Y, Shiraishi K, Hayakawa K, Nakagawa K - Pulm Med (2012)

Bottom Line: The most commonly observed late effect was radiation pneumonitis.No other ≧ grade 3 acute and late adverse events occurred.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

ABSTRACT
Purpose. To investigate the outcome and toxicity of stereotactic body radiotherapy (SBRT) in patients with oligo-recurrence cancer in the lung (ORCL). Methods and Materials. A retrospective review of 42 patients with ORCL who underwent SBRT in our two hospitals was conducted. We evaluated the outcome and adverse effects after SBRT for ORCL. Results. All patients finished their SBRT course without interruptions of toxicity reasons. The median follow-up period was 20 months (range, 1-90 months). The 2-year local control rate and overall survival were 87% (95% CI, 75-99%) and 65% (95% CI, 48-82%). As for prognostic factor, the OS of patients with a short disease-free interval (DFI) <31.9 months, between the initial therapy and SBRT for ORCL, was significantly worse than the OS of long DFI ≧31.9 months (P < 0.05). The most commonly observed late effect was radiation pneumonitis. One patient had grade 4 gastrointestinal toxicity (perforation of gastric tube). No other ≧ grade 3 acute and late adverse events occurred. There were no treatment-related deaths during this study. Conclusions. In patients with ORCL, radical treatment with SBRT is safe and provides a chance for long-term survival by offering favorable local control.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier curves for local control in 42 patients with oligo-recurrence cancer in the lung, early recurrence group versus late recurrence group.
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fig4: Kaplan-Meier curves for local control in 42 patients with oligo-recurrence cancer in the lung, early recurrence group versus late recurrence group.

Mentions: We also analyzed the LCR and OS differences stratified by DFI divided into <31.9 or ≧31.9 months. As shown in Figure 4, the result indicated a negative correlation between DFI and LCR (P = 0.29). On the other hand, early recurrence group (short DFI) had significantly bad prognosis (P < 0.05; Figure 5).


Stereotactic body radiotherapy for metastatic lung cancer as oligo-recurrence: an analysis of 42 cases.

Takahashi W, Yamashita H, Niibe Y, Shiraishi K, Hayakawa K, Nakagawa K - Pulm Med (2012)

Kaplan-Meier curves for local control in 42 patients with oligo-recurrence cancer in the lung, early recurrence group versus late recurrence group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3472526&req=5

fig4: Kaplan-Meier curves for local control in 42 patients with oligo-recurrence cancer in the lung, early recurrence group versus late recurrence group.
Mentions: We also analyzed the LCR and OS differences stratified by DFI divided into <31.9 or ≧31.9 months. As shown in Figure 4, the result indicated a negative correlation between DFI and LCR (P = 0.29). On the other hand, early recurrence group (short DFI) had significantly bad prognosis (P < 0.05; Figure 5).

Bottom Line: The most commonly observed late effect was radiation pneumonitis.No other ≧ grade 3 acute and late adverse events occurred.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

ABSTRACT
Purpose. To investigate the outcome and toxicity of stereotactic body radiotherapy (SBRT) in patients with oligo-recurrence cancer in the lung (ORCL). Methods and Materials. A retrospective review of 42 patients with ORCL who underwent SBRT in our two hospitals was conducted. We evaluated the outcome and adverse effects after SBRT for ORCL. Results. All patients finished their SBRT course without interruptions of toxicity reasons. The median follow-up period was 20 months (range, 1-90 months). The 2-year local control rate and overall survival were 87% (95% CI, 75-99%) and 65% (95% CI, 48-82%). As for prognostic factor, the OS of patients with a short disease-free interval (DFI) <31.9 months, between the initial therapy and SBRT for ORCL, was significantly worse than the OS of long DFI ≧31.9 months (P < 0.05). The most commonly observed late effect was radiation pneumonitis. One patient had grade 4 gastrointestinal toxicity (perforation of gastric tube). No other ≧ grade 3 acute and late adverse events occurred. There were no treatment-related deaths during this study. Conclusions. In patients with ORCL, radical treatment with SBRT is safe and provides a chance for long-term survival by offering favorable local control.

No MeSH data available.


Related in: MedlinePlus