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Th17 mediated alloreactivity is facilitated by the pre-transplant microbial burden of the recipient.

Klimczak A, Lange A - Bone Marrow Res (2012)

Bottom Line: Acute graft-versus-host disease (aGvHD) is a major complication after hematopoietic stem cell transplantation (HSCT) and severity of aGvHD is associated with biological and genetic factors related to donors and recipients.Cytokine deregulation may increase or reduce the risk of aGvHD.Damage of tissues affected by aGvHD reflects the immunological cascade of events in this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Immunology, L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Rudolfa Weigla Street, 53-114 Wroclaw, Poland.

ABSTRACT
Acute graft-versus-host disease (aGvHD) is a major complication after hematopoietic stem cell transplantation (HSCT) and severity of aGvHD is associated with biological and genetic factors related to donors and recipients. Studies on inflammatory pathways involved in aGvHD have shown a significant impact of the gut microflora on aGvHD development giving increasing evidence in the understanding of the response of innate and adaptive immunity to microbial products. Cytokine deregulation may increase or reduce the risk of aGvHD. Damage of tissues affected by aGvHD reflects the immunological cascade of events in this disease.

No MeSH data available.


Related in: MedlinePlus

Colon biopsy specimen harvested at day 63 after HSCT from patient with clinical symptoms of aGvHD. IL-17 producing cells and macrophages CD68+ were seen within cellular infiltrates (brown staining with diaminobenzidine-tetrahydrochloride (DAB) and red staining with Permanent Red, magnifications 400x).
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fig3: Colon biopsy specimen harvested at day 63 after HSCT from patient with clinical symptoms of aGvHD. IL-17 producing cells and macrophages CD68+ were seen within cellular infiltrates (brown staining with diaminobenzidine-tetrahydrochloride (DAB) and red staining with Permanent Red, magnifications 400x).

Mentions: Following more recent observations it is known that the differentiation process of CD4+ cells into subsets depends on the cytokine milieu in their environment [31]. IL-6, if present, facilitates differentiation of CD4+ cells into Th17 cells [32, 33]. IL-17 is a cytokine of the strongest proinflammatory potential. It is known that differentiation of lymphocytes into Th17 cells may take place in the gut, where microbial products provide strong stimulation for local IL-6 production [34]. Therefore, it is not surprising that in intestinal aGvHD IL-17 producing cells are present among those infiltrating affected tissue (Figure 3) [35]. Local IL-17 production in the gut during aGvHD is seen in patients with extensive diarrhea resulting from profound damage of intestinal epithelium.


Th17 mediated alloreactivity is facilitated by the pre-transplant microbial burden of the recipient.

Klimczak A, Lange A - Bone Marrow Res (2012)

Colon biopsy specimen harvested at day 63 after HSCT from patient with clinical symptoms of aGvHD. IL-17 producing cells and macrophages CD68+ were seen within cellular infiltrates (brown staining with diaminobenzidine-tetrahydrochloride (DAB) and red staining with Permanent Red, magnifications 400x).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472510&req=5

fig3: Colon biopsy specimen harvested at day 63 after HSCT from patient with clinical symptoms of aGvHD. IL-17 producing cells and macrophages CD68+ were seen within cellular infiltrates (brown staining with diaminobenzidine-tetrahydrochloride (DAB) and red staining with Permanent Red, magnifications 400x).
Mentions: Following more recent observations it is known that the differentiation process of CD4+ cells into subsets depends on the cytokine milieu in their environment [31]. IL-6, if present, facilitates differentiation of CD4+ cells into Th17 cells [32, 33]. IL-17 is a cytokine of the strongest proinflammatory potential. It is known that differentiation of lymphocytes into Th17 cells may take place in the gut, where microbial products provide strong stimulation for local IL-6 production [34]. Therefore, it is not surprising that in intestinal aGvHD IL-17 producing cells are present among those infiltrating affected tissue (Figure 3) [35]. Local IL-17 production in the gut during aGvHD is seen in patients with extensive diarrhea resulting from profound damage of intestinal epithelium.

Bottom Line: Acute graft-versus-host disease (aGvHD) is a major complication after hematopoietic stem cell transplantation (HSCT) and severity of aGvHD is associated with biological and genetic factors related to donors and recipients.Cytokine deregulation may increase or reduce the risk of aGvHD.Damage of tissues affected by aGvHD reflects the immunological cascade of events in this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Immunology, L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Rudolfa Weigla Street, 53-114 Wroclaw, Poland.

ABSTRACT
Acute graft-versus-host disease (aGvHD) is a major complication after hematopoietic stem cell transplantation (HSCT) and severity of aGvHD is associated with biological and genetic factors related to donors and recipients. Studies on inflammatory pathways involved in aGvHD have shown a significant impact of the gut microflora on aGvHD development giving increasing evidence in the understanding of the response of innate and adaptive immunity to microbial products. Cytokine deregulation may increase or reduce the risk of aGvHD. Damage of tissues affected by aGvHD reflects the immunological cascade of events in this disease.

No MeSH data available.


Related in: MedlinePlus