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Sexually dimorphic effects of oxytocin receptor gene (OXTR ) variants on Harm Avoidance.

Stankova T, Eichhammer P, Langguth B, Sand PG - Biol Sex Differ (2012)

Bottom Line: Recent research has suggested that oxytocin receptor gene (OXTR) variants may account for individual differences in social behavior, the effects of stress and parenting styles.We addressed effects of two common OXTR variants, rs237900 and rs237902, on personality dimensions in 99 healthy subjects using the Temperament and Character Inventory.Female carriers of the minor alleles scored highest, and a novel A217T mutation emerged in the most harm avoidant male participant.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstrasse 84, 93053 Regensburg, Germany. philipp.sand@klinik.uni-regensburg.de.

ABSTRACT

Background: Recent research has suggested that oxytocin receptor gene (OXTR) variants may account for individual differences in social behavior, the effects of stress and parenting styles. Little is known, however, on a putative role of the gene in heritable temperamental traits.

Methods: We addressed effects of two common OXTR variants, rs237900 and rs237902, on personality dimensions in 99 healthy subjects using the Temperament and Character Inventory.

Results: When sex was controlled for and an OXTR genotype*sex interaction term was included in the regression model, 11% of the variance in Harm Avoidance could be explained (uncorrected p ≤ 0.01). Female carriers of the minor alleles scored highest, and a novel A217T mutation emerged in the most harm avoidant male participant.

Conclusions: Findings lend support to a modulatory effect of common OXTR variants on Harm Avoidance in healthy caucasian women and invite resequencing of the gene in anxiety phenotypes to identify more explanatory functional variation.

No MeSH data available.


Related in: MedlinePlus

Interaction of OXTR genotype ( t =1.26, p =0.20) and sex ( t =−3.05, p =0.003) as predictors of Harm Avoidance mean scores.
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Figure 1: Interaction of OXTR genotype ( t =1.26, p =0.20) and sex ( t =−3.05, p =0.003) as predictors of Harm Avoidance mean scores.

Mentions: TCI scores conformed to a normal distribution for NS, HA, and RD, but not for PS. Consistent with previous research [19], PS scores were therefore log-transformed before statistical analyses to ensure Gaussian distributions across all scales (Shapiro-Wilk test of transformed data p > 0.67; reported means and SDs are not transformed for ease of interpretation). Effects of rs237900 and rs237902 on the TCI temperamental scales were non-significant when data from men and women were pooled (F < 1.25, p > 0.26). However, when sex was controlled for, both OXTR variants under study predicted Harm Avoidance in multiple regression models (p = 0.01 for rs237902, p = 0.006 for rs237900). Considering moderate to strong intermarker linkage disequilibrium (r2 = 0.75), we limited our analyses to rs237900 (Table 1). To avoid trade-offs in power, CT and TT genotypes were collapsed into T carriers and were then contrasted with the remaining subjects under the assumption of a recessive mode of inheritance (mean HA scores ± SD: CC = 13.4 ±4.7, CT = 14.3 ±6.3, TT = 14.3 ±5.1). Following a Bonferroni correction for eight separate regressions (effects of genotype on four temperamental scales with and without sex as a second factor), significance was still achieved (p = 0.045). Female carriers of the minor allele (T) scored higher on Harm Avoidance than did all other subjects. Even though only sex appeared to exert a main effect in the additive model (Figure 1), the variance explained by both regressor variables reached 11% when an interaction term was included (Table 1, 10% assuming no interaction). No noteworthy effect was observed on Novelty Seeking, Reward Dependence or Persistence.


Sexually dimorphic effects of oxytocin receptor gene (OXTR ) variants on Harm Avoidance.

Stankova T, Eichhammer P, Langguth B, Sand PG - Biol Sex Differ (2012)

Interaction of OXTR genotype ( t =1.26, p =0.20) and sex ( t =−3.05, p =0.003) as predictors of Harm Avoidance mean scores.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472235&req=5

Figure 1: Interaction of OXTR genotype ( t =1.26, p =0.20) and sex ( t =−3.05, p =0.003) as predictors of Harm Avoidance mean scores.
Mentions: TCI scores conformed to a normal distribution for NS, HA, and RD, but not for PS. Consistent with previous research [19], PS scores were therefore log-transformed before statistical analyses to ensure Gaussian distributions across all scales (Shapiro-Wilk test of transformed data p > 0.67; reported means and SDs are not transformed for ease of interpretation). Effects of rs237900 and rs237902 on the TCI temperamental scales were non-significant when data from men and women were pooled (F < 1.25, p > 0.26). However, when sex was controlled for, both OXTR variants under study predicted Harm Avoidance in multiple regression models (p = 0.01 for rs237902, p = 0.006 for rs237900). Considering moderate to strong intermarker linkage disequilibrium (r2 = 0.75), we limited our analyses to rs237900 (Table 1). To avoid trade-offs in power, CT and TT genotypes were collapsed into T carriers and were then contrasted with the remaining subjects under the assumption of a recessive mode of inheritance (mean HA scores ± SD: CC = 13.4 ±4.7, CT = 14.3 ±6.3, TT = 14.3 ±5.1). Following a Bonferroni correction for eight separate regressions (effects of genotype on four temperamental scales with and without sex as a second factor), significance was still achieved (p = 0.045). Female carriers of the minor allele (T) scored higher on Harm Avoidance than did all other subjects. Even though only sex appeared to exert a main effect in the additive model (Figure 1), the variance explained by both regressor variables reached 11% when an interaction term was included (Table 1, 10% assuming no interaction). No noteworthy effect was observed on Novelty Seeking, Reward Dependence or Persistence.

Bottom Line: Recent research has suggested that oxytocin receptor gene (OXTR) variants may account for individual differences in social behavior, the effects of stress and parenting styles.We addressed effects of two common OXTR variants, rs237900 and rs237902, on personality dimensions in 99 healthy subjects using the Temperament and Character Inventory.Female carriers of the minor alleles scored highest, and a novel A217T mutation emerged in the most harm avoidant male participant.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstrasse 84, 93053 Regensburg, Germany. philipp.sand@klinik.uni-regensburg.de.

ABSTRACT

Background: Recent research has suggested that oxytocin receptor gene (OXTR) variants may account for individual differences in social behavior, the effects of stress and parenting styles. Little is known, however, on a putative role of the gene in heritable temperamental traits.

Methods: We addressed effects of two common OXTR variants, rs237900 and rs237902, on personality dimensions in 99 healthy subjects using the Temperament and Character Inventory.

Results: When sex was controlled for and an OXTR genotype*sex interaction term was included in the regression model, 11% of the variance in Harm Avoidance could be explained (uncorrected p ≤ 0.01). Female carriers of the minor alleles scored highest, and a novel A217T mutation emerged in the most harm avoidant male participant.

Conclusions: Findings lend support to a modulatory effect of common OXTR variants on Harm Avoidance in healthy caucasian women and invite resequencing of the gene in anxiety phenotypes to identify more explanatory functional variation.

No MeSH data available.


Related in: MedlinePlus