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Undersampled cine 3D tagging for rapid assessment of cardiac motion.

Stoeck CT, Manka R, Boesiger P, Kozerke S - J Cardiovasc Magn Reson (2012)

Bottom Line: Comparison of results from fully sampled in-vivo data acquired with prospectively undersampled acquisitions showed a mean difference in circumferential shortening of -0.14 ± 5.18% and 0.71 ± 6.16% for R = 3 and 4.In patients peak, circumferential shortening was significantly reduced (p < 0.002 for all patients) in regions with late gadolinium enhancement.Undersampled cine 3D tagging enables significant reduction in scan time of whole-heart tagging and facilitates quantification of shortening, rotation and torsion of the left ventricle without adding significant errors compared to previous 3D tagging approaches.

View Article: PubMed Central - PubMed

Affiliation: Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, 8092, Zurich, Switzerland.

ABSTRACT

Background: CMR allows investigating cardiac contraction, rotation and torsion non-invasively by the use of tagging sequences. Three-dimensional tagging has been proposed to cover the whole-heart but data acquisition requires three consecutive breath holds and hence demands considerable patient cooperation. In this study we have implemented and studied k-t undersampled cine 3D tagging in conjunction with k-t PCA reconstruction to potentially permit for single breath-hold acquisitions.

Methods: The performance of undersampled cine 3D tagging was investigated using computer simulations and in-vivo measurements in 8 healthy subjects and 5 patients with myocardial infarction. Fully sampled data was obtained and compared to retrospectively and prospectively undersampled acquisitions. Fully sampled data was acquired in three consecutive breath holds. Prospectively undersampled data was obtained within a single breath hold. Based on harmonic phase (HARP) analysis, circumferential shortening, rotation and torsion were compared between fully sampled and undersampled data using Bland-Altman and linear regression analysis.

Results: In computer simulations, the error for circumferential shortening was 2.8 ± 2.3% and 2.7 ± 2.1% for undersampling rates of R = 3 and 4 respectively. Errors in ventricular rotation were 2.5 ± 1.9% and 3.0 ± 2.2% for R = 3 and 4. Comparison of results from fully sampled in-vivo data acquired with prospectively undersampled acquisitions showed a mean difference in circumferential shortening of -0.14 ± 5.18% and 0.71 ± 6.16% for R = 3 and 4. The mean differences in rotation were 0.44 ± 1.8° and 0.73 ± 1.67° for R = 3 and 4, respectively. In patients peak, circumferential shortening was significantly reduced (p < 0.002 for all patients) in regions with late gadolinium enhancement.

Conclusion: Undersampled cine 3D tagging enables significant reduction in scan time of whole-heart tagging and facilitates quantification of shortening, rotation and torsion of the left ventricle without adding significant errors compared to previous 3D tagging approaches.

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Related in: MedlinePlus

Comparison of circumferential shortening and rotation for fully sampled reference data and retrospectively undersampled data from computer simulation. Relative differences are presented as average over the entire LV (a-b) along with slope and offset of linear regression and the corresponding correlation coefficient R2 and the standard error of the estimate (SEE) (c-j).
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Figure 4: Comparison of circumferential shortening and rotation for fully sampled reference data and retrospectively undersampled data from computer simulation. Relative differences are presented as average over the entire LV (a-b) along with slope and offset of linear regression and the corresponding correlation coefficient R2 and the standard error of the estimate (SEE) (c-j).

Mentions: Normalized differences in peak circumferential shortening and rotation between undersampling factors of R = 3, 4, 5 and 8 and fully sampled data used as reference are shown in Figure 4a-b. Errors in circumferential shortening and rotation were below 5% for undersampling factors of R = 3–5 and R = 3, 4, respectively. At R = 8 errors in circumferential shortening and rotation were 2.5 and 3.1 times greater compared to data obtained with R = 4. The differences in torsion between undersampled and fully sampled data were −0.13°, 0.42°, 0.95° and 1.85° for R = 3, 4, 5 and 8, respectively.


Undersampled cine 3D tagging for rapid assessment of cardiac motion.

Stoeck CT, Manka R, Boesiger P, Kozerke S - J Cardiovasc Magn Reson (2012)

Comparison of circumferential shortening and rotation for fully sampled reference data and retrospectively undersampled data from computer simulation. Relative differences are presented as average over the entire LV (a-b) along with slope and offset of linear regression and the corresponding correlation coefficient R2 and the standard error of the estimate (SEE) (c-j).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472184&req=5

Figure 4: Comparison of circumferential shortening and rotation for fully sampled reference data and retrospectively undersampled data from computer simulation. Relative differences are presented as average over the entire LV (a-b) along with slope and offset of linear regression and the corresponding correlation coefficient R2 and the standard error of the estimate (SEE) (c-j).
Mentions: Normalized differences in peak circumferential shortening and rotation between undersampling factors of R = 3, 4, 5 and 8 and fully sampled data used as reference are shown in Figure 4a-b. Errors in circumferential shortening and rotation were below 5% for undersampling factors of R = 3–5 and R = 3, 4, respectively. At R = 8 errors in circumferential shortening and rotation were 2.5 and 3.1 times greater compared to data obtained with R = 4. The differences in torsion between undersampled and fully sampled data were −0.13°, 0.42°, 0.95° and 1.85° for R = 3, 4, 5 and 8, respectively.

Bottom Line: Comparison of results from fully sampled in-vivo data acquired with prospectively undersampled acquisitions showed a mean difference in circumferential shortening of -0.14 ± 5.18% and 0.71 ± 6.16% for R = 3 and 4.In patients peak, circumferential shortening was significantly reduced (p < 0.002 for all patients) in regions with late gadolinium enhancement.Undersampled cine 3D tagging enables significant reduction in scan time of whole-heart tagging and facilitates quantification of shortening, rotation and torsion of the left ventricle without adding significant errors compared to previous 3D tagging approaches.

View Article: PubMed Central - PubMed

Affiliation: Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, 8092, Zurich, Switzerland.

ABSTRACT

Background: CMR allows investigating cardiac contraction, rotation and torsion non-invasively by the use of tagging sequences. Three-dimensional tagging has been proposed to cover the whole-heart but data acquisition requires three consecutive breath holds and hence demands considerable patient cooperation. In this study we have implemented and studied k-t undersampled cine 3D tagging in conjunction with k-t PCA reconstruction to potentially permit for single breath-hold acquisitions.

Methods: The performance of undersampled cine 3D tagging was investigated using computer simulations and in-vivo measurements in 8 healthy subjects and 5 patients with myocardial infarction. Fully sampled data was obtained and compared to retrospectively and prospectively undersampled acquisitions. Fully sampled data was acquired in three consecutive breath holds. Prospectively undersampled data was obtained within a single breath hold. Based on harmonic phase (HARP) analysis, circumferential shortening, rotation and torsion were compared between fully sampled and undersampled data using Bland-Altman and linear regression analysis.

Results: In computer simulations, the error for circumferential shortening was 2.8 ± 2.3% and 2.7 ± 2.1% for undersampling rates of R = 3 and 4 respectively. Errors in ventricular rotation were 2.5 ± 1.9% and 3.0 ± 2.2% for R = 3 and 4. Comparison of results from fully sampled in-vivo data acquired with prospectively undersampled acquisitions showed a mean difference in circumferential shortening of -0.14 ± 5.18% and 0.71 ± 6.16% for R = 3 and 4. The mean differences in rotation were 0.44 ± 1.8° and 0.73 ± 1.67° for R = 3 and 4, respectively. In patients peak, circumferential shortening was significantly reduced (p < 0.002 for all patients) in regions with late gadolinium enhancement.

Conclusion: Undersampled cine 3D tagging enables significant reduction in scan time of whole-heart tagging and facilitates quantification of shortening, rotation and torsion of the left ventricle without adding significant errors compared to previous 3D tagging approaches.

Show MeSH
Related in: MedlinePlus