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Undersampled cine 3D tagging for rapid assessment of cardiac motion.

Stoeck CT, Manka R, Boesiger P, Kozerke S - J Cardiovasc Magn Reson (2012)

Bottom Line: Comparison of results from fully sampled in-vivo data acquired with prospectively undersampled acquisitions showed a mean difference in circumferential shortening of -0.14 ± 5.18% and 0.71 ± 6.16% for R = 3 and 4.In patients peak, circumferential shortening was significantly reduced (p < 0.002 for all patients) in regions with late gadolinium enhancement.Undersampled cine 3D tagging enables significant reduction in scan time of whole-heart tagging and facilitates quantification of shortening, rotation and torsion of the left ventricle without adding significant errors compared to previous 3D tagging approaches.

View Article: PubMed Central - PubMed

Affiliation: Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, 8092, Zurich, Switzerland.

ABSTRACT

Background: CMR allows investigating cardiac contraction, rotation and torsion non-invasively by the use of tagging sequences. Three-dimensional tagging has been proposed to cover the whole-heart but data acquisition requires three consecutive breath holds and hence demands considerable patient cooperation. In this study we have implemented and studied k-t undersampled cine 3D tagging in conjunction with k-t PCA reconstruction to potentially permit for single breath-hold acquisitions.

Methods: The performance of undersampled cine 3D tagging was investigated using computer simulations and in-vivo measurements in 8 healthy subjects and 5 patients with myocardial infarction. Fully sampled data was obtained and compared to retrospectively and prospectively undersampled acquisitions. Fully sampled data was acquired in three consecutive breath holds. Prospectively undersampled data was obtained within a single breath hold. Based on harmonic phase (HARP) analysis, circumferential shortening, rotation and torsion were compared between fully sampled and undersampled data using Bland-Altman and linear regression analysis.

Results: In computer simulations, the error for circumferential shortening was 2.8 ± 2.3% and 2.7 ± 2.1% for undersampling rates of R = 3 and 4 respectively. Errors in ventricular rotation were 2.5 ± 1.9% and 3.0 ± 2.2% for R = 3 and 4. Comparison of results from fully sampled in-vivo data acquired with prospectively undersampled acquisitions showed a mean difference in circumferential shortening of -0.14 ± 5.18% and 0.71 ± 6.16% for R = 3 and 4. The mean differences in rotation were 0.44 ± 1.8° and 0.73 ± 1.67° for R = 3 and 4, respectively. In patients peak, circumferential shortening was significantly reduced (p < 0.002 for all patients) in regions with late gadolinium enhancement.

Conclusion: Undersampled cine 3D tagging enables significant reduction in scan time of whole-heart tagging and facilitates quantification of shortening, rotation and torsion of the left ventricle without adding significant errors compared to previous 3D tagging approaches.

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Related in: MedlinePlus

Maps of peak circumferential shortening (csh) for five patients with myocardial infarction. The top row represents results from fully sampled data while the second row shows data from prospectively undersampled acquisitions. The third row shows the result of late gadolinium enhancement imaging (LGE). The myocardial signal intensity post contrast was averaged over each sector and normalized to the signal intensity from completely infarcted tissue. The bottom row shows box-plots of peak circumferential shortening for sectors with more than 50% late gadolinium enhanced signal (grey) and sectors with less than 50% late gadolinium enhanced signal (black). The box represents 50% of the data points and the error bars 90%. Statistical significance is indicated by # for p < 0.002 and * for p < 0.0002.
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Figure 10: Maps of peak circumferential shortening (csh) for five patients with myocardial infarction. The top row represents results from fully sampled data while the second row shows data from prospectively undersampled acquisitions. The third row shows the result of late gadolinium enhancement imaging (LGE). The myocardial signal intensity post contrast was averaged over each sector and normalized to the signal intensity from completely infarcted tissue. The bottom row shows box-plots of peak circumferential shortening for sectors with more than 50% late gadolinium enhanced signal (grey) and sectors with less than 50% late gadolinium enhanced signal (black). The box represents 50% of the data points and the error bars 90%. Statistical significance is indicated by # for p < 0.002 and * for p < 0.0002.

Mentions: Figure 10 compares circumferential shortening obtained from undersampled and fully sampled reference data for the five patients in relation the LGE findings. Differences in peak circumferential shortening in sectors with more than 50% of their area presenting LGE and sectors with less than 50% LGE were statistically significant in all patients. Mean difference ± 2SD in torsion between undersampled and fully sampled reference data in patients was 0.72 ± 2.14°. The SNR in the fully sampled in-vivo data was 36 ± 12 on average.


Undersampled cine 3D tagging for rapid assessment of cardiac motion.

Stoeck CT, Manka R, Boesiger P, Kozerke S - J Cardiovasc Magn Reson (2012)

Maps of peak circumferential shortening (csh) for five patients with myocardial infarction. The top row represents results from fully sampled data while the second row shows data from prospectively undersampled acquisitions. The third row shows the result of late gadolinium enhancement imaging (LGE). The myocardial signal intensity post contrast was averaged over each sector and normalized to the signal intensity from completely infarcted tissue. The bottom row shows box-plots of peak circumferential shortening for sectors with more than 50% late gadolinium enhanced signal (grey) and sectors with less than 50% late gadolinium enhanced signal (black). The box represents 50% of the data points and the error bars 90%. Statistical significance is indicated by # for p < 0.002 and * for p < 0.0002.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472184&req=5

Figure 10: Maps of peak circumferential shortening (csh) for five patients with myocardial infarction. The top row represents results from fully sampled data while the second row shows data from prospectively undersampled acquisitions. The third row shows the result of late gadolinium enhancement imaging (LGE). The myocardial signal intensity post contrast was averaged over each sector and normalized to the signal intensity from completely infarcted tissue. The bottom row shows box-plots of peak circumferential shortening for sectors with more than 50% late gadolinium enhanced signal (grey) and sectors with less than 50% late gadolinium enhanced signal (black). The box represents 50% of the data points and the error bars 90%. Statistical significance is indicated by # for p < 0.002 and * for p < 0.0002.
Mentions: Figure 10 compares circumferential shortening obtained from undersampled and fully sampled reference data for the five patients in relation the LGE findings. Differences in peak circumferential shortening in sectors with more than 50% of their area presenting LGE and sectors with less than 50% LGE were statistically significant in all patients. Mean difference ± 2SD in torsion between undersampled and fully sampled reference data in patients was 0.72 ± 2.14°. The SNR in the fully sampled in-vivo data was 36 ± 12 on average.

Bottom Line: Comparison of results from fully sampled in-vivo data acquired with prospectively undersampled acquisitions showed a mean difference in circumferential shortening of -0.14 ± 5.18% and 0.71 ± 6.16% for R = 3 and 4.In patients peak, circumferential shortening was significantly reduced (p < 0.002 for all patients) in regions with late gadolinium enhancement.Undersampled cine 3D tagging enables significant reduction in scan time of whole-heart tagging and facilitates quantification of shortening, rotation and torsion of the left ventricle without adding significant errors compared to previous 3D tagging approaches.

View Article: PubMed Central - PubMed

Affiliation: Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, 8092, Zurich, Switzerland.

ABSTRACT

Background: CMR allows investigating cardiac contraction, rotation and torsion non-invasively by the use of tagging sequences. Three-dimensional tagging has been proposed to cover the whole-heart but data acquisition requires three consecutive breath holds and hence demands considerable patient cooperation. In this study we have implemented and studied k-t undersampled cine 3D tagging in conjunction with k-t PCA reconstruction to potentially permit for single breath-hold acquisitions.

Methods: The performance of undersampled cine 3D tagging was investigated using computer simulations and in-vivo measurements in 8 healthy subjects and 5 patients with myocardial infarction. Fully sampled data was obtained and compared to retrospectively and prospectively undersampled acquisitions. Fully sampled data was acquired in three consecutive breath holds. Prospectively undersampled data was obtained within a single breath hold. Based on harmonic phase (HARP) analysis, circumferential shortening, rotation and torsion were compared between fully sampled and undersampled data using Bland-Altman and linear regression analysis.

Results: In computer simulations, the error for circumferential shortening was 2.8 ± 2.3% and 2.7 ± 2.1% for undersampling rates of R = 3 and 4 respectively. Errors in ventricular rotation were 2.5 ± 1.9% and 3.0 ± 2.2% for R = 3 and 4. Comparison of results from fully sampled in-vivo data acquired with prospectively undersampled acquisitions showed a mean difference in circumferential shortening of -0.14 ± 5.18% and 0.71 ± 6.16% for R = 3 and 4. The mean differences in rotation were 0.44 ± 1.8° and 0.73 ± 1.67° for R = 3 and 4, respectively. In patients peak, circumferential shortening was significantly reduced (p < 0.002 for all patients) in regions with late gadolinium enhancement.

Conclusion: Undersampled cine 3D tagging enables significant reduction in scan time of whole-heart tagging and facilitates quantification of shortening, rotation and torsion of the left ventricle without adding significant errors compared to previous 3D tagging approaches.

Show MeSH
Related in: MedlinePlus