Setting an agenda for comparative effectiveness systematic reviews in CKD care.
Bottom Line: We engaged stakeholders in the chronic kidney disease community to prioritize topics for future comparative effectiveness research systematic reviews.We developed a preliminary list of suggested topics and stakeholders refined and ranked topics based on their importance.Among 46 topics identified, stakeholders nominated 18 as 'high' priority.
Systematic reviews comparing the effectiveness of strategies to prevent, detect, and treat chronic kidney disease are needed to inform patient care. We engaged stakeholders in the chronic kidney disease community to prioritize topics for future comparative effectiveness research systematic reviews. We developed a preliminary list of suggested topics and stakeholders refined and ranked topics based on their importance. Among 46 topics identified, stakeholders nominated 18 as 'high' priority. Most pertained to strategies to slow disease progression, including: (a) treat proteinuria, (b) improve access to care, (c) treat hypertension, (d) use health information technology, and (e) implement dietary strategies. Most (15 of 18) topics had been previously studied with two or more randomized controlled trials, indicating feasibility of rigorous systematic reviews. Chronic kidney disease topics rated by stakeholders as 'high priority' are varied in scope and may lead to quality systematic reviews impacting practice and policy.
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Mentions: We established a preliminary protocol for identifying and prioritizing topics, which we later revised with input from the stakeholders. The protocol consisted of three main activities: (1) identifying and categorizing potential topics of interest to the CKD community for systematic review and primary CER studies, (2) asking stakeholders to rank topics that would be of greatest interest to the CKD community, and (3) exploring the feasibility of performing CER systematic reviews on these high priority topics (Figure 1).