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Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats.

Tarameshloo M, Norouzian M, Zarein-Dolab S, Dadpay M, Mohsenifar J, Gazor R - Anat Cell Biol (2012)

Bottom Line: Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science.The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats.Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy and Cell Biology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

ABSTRACT
Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science. The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats. In a randomized controlled trial, thirty-six Wistar male rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05). Topical administration of Aloe vera gel is recommended as the treatment of choice for surgical incisions.

No MeSH data available.


Related in: MedlinePlus

Comparison of histological properties of incision wounds 14 days after surgery. Alphabetical letters show significant differences. Values are presented as mean±SEM. AV, Aloe vera; TC, thyroid hormone cream; SSD, silver sulfadiazine cream; V, vehicle; C, control; FB, fibroblast; MAC, macrophage; NEUT, neutrophil; VES, vessel sections; EPI; epithelial thickness; DERM, dermal thickness; mean±SEM, mean values±standard error of means of six experiments.
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Figure 6: Comparison of histological properties of incision wounds 14 days after surgery. Alphabetical letters show significant differences. Values are presented as mean±SEM. AV, Aloe vera; TC, thyroid hormone cream; SSD, silver sulfadiazine cream; V, vehicle; C, control; FB, fibroblast; MAC, macrophage; NEUT, neutrophil; VES, vessel sections; EPI; epithelial thickness; DERM, dermal thickness; mean±SEM, mean values±standard error of means of six experiments.

Mentions: As Figs. 6 and 7 indicate only the mean number of neutrophils in V and control groups was significantly higher than that in AV, TC and S groups (P≤0.05). Nevertheless, no significant differences were observed among the AV, TC and S groups.


Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats.

Tarameshloo M, Norouzian M, Zarein-Dolab S, Dadpay M, Mohsenifar J, Gazor R - Anat Cell Biol (2012)

Comparison of histological properties of incision wounds 14 days after surgery. Alphabetical letters show significant differences. Values are presented as mean±SEM. AV, Aloe vera; TC, thyroid hormone cream; SSD, silver sulfadiazine cream; V, vehicle; C, control; FB, fibroblast; MAC, macrophage; NEUT, neutrophil; VES, vessel sections; EPI; epithelial thickness; DERM, dermal thickness; mean±SEM, mean values±standard error of means of six experiments.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472143&req=5

Figure 6: Comparison of histological properties of incision wounds 14 days after surgery. Alphabetical letters show significant differences. Values are presented as mean±SEM. AV, Aloe vera; TC, thyroid hormone cream; SSD, silver sulfadiazine cream; V, vehicle; C, control; FB, fibroblast; MAC, macrophage; NEUT, neutrophil; VES, vessel sections; EPI; epithelial thickness; DERM, dermal thickness; mean±SEM, mean values±standard error of means of six experiments.
Mentions: As Figs. 6 and 7 indicate only the mean number of neutrophils in V and control groups was significantly higher than that in AV, TC and S groups (P≤0.05). Nevertheless, no significant differences were observed among the AV, TC and S groups.

Bottom Line: Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science.The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats.Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy and Cell Biology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

ABSTRACT
Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science. The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats. In a randomized controlled trial, thirty-six Wistar male rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05). Topical administration of Aloe vera gel is recommended as the treatment of choice for surgical incisions.

No MeSH data available.


Related in: MedlinePlus