Limits...
Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats.

Tarameshloo M, Norouzian M, Zarein-Dolab S, Dadpay M, Mohsenifar J, Gazor R - Anat Cell Biol (2012)

Bottom Line: Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science.The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats.Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy and Cell Biology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

ABSTRACT
Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science. The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats. In a randomized controlled trial, thirty-six Wistar male rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05). Topical administration of Aloe vera gel is recommended as the treatment of choice for surgical incisions.

No MeSH data available.


Related in: MedlinePlus

Light micrographs (100×) of incisional wound bed of (A) Aloe vera group (n=6), (B) thyroid hormone cream group (n=6), (C) silver sulfadiazine cream group (n=6), (D) vehicle group (n=6), (E) control group (n=6) 4 days after surgery. Arrows depict blood vessel sections in Aloe vera and thyroid hormone cream groups. Scale bars=100 µm (A-E).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3472143&req=5

Figure 3: Light micrographs (100×) of incisional wound bed of (A) Aloe vera group (n=6), (B) thyroid hormone cream group (n=6), (C) silver sulfadiazine cream group (n=6), (D) vehicle group (n=6), (E) control group (n=6) 4 days after surgery. Arrows depict blood vessel sections in Aloe vera and thyroid hormone cream groups. Scale bars=100 µm (A-E).

Mentions: As Figs. 2 and 3 indicate the mean number of fibroblasts and blood vessel sections in AV and TC groups were significantly higher than those in V and control groups (P≤0.05). Nevertheless, no significant differences were observed among the AV and TC groups. Also these parameters were not significantly different among the S, V and control groups.


Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats.

Tarameshloo M, Norouzian M, Zarein-Dolab S, Dadpay M, Mohsenifar J, Gazor R - Anat Cell Biol (2012)

Light micrographs (100×) of incisional wound bed of (A) Aloe vera group (n=6), (B) thyroid hormone cream group (n=6), (C) silver sulfadiazine cream group (n=6), (D) vehicle group (n=6), (E) control group (n=6) 4 days after surgery. Arrows depict blood vessel sections in Aloe vera and thyroid hormone cream groups. Scale bars=100 µm (A-E).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472143&req=5

Figure 3: Light micrographs (100×) of incisional wound bed of (A) Aloe vera group (n=6), (B) thyroid hormone cream group (n=6), (C) silver sulfadiazine cream group (n=6), (D) vehicle group (n=6), (E) control group (n=6) 4 days after surgery. Arrows depict blood vessel sections in Aloe vera and thyroid hormone cream groups. Scale bars=100 µm (A-E).
Mentions: As Figs. 2 and 3 indicate the mean number of fibroblasts and blood vessel sections in AV and TC groups were significantly higher than those in V and control groups (P≤0.05). Nevertheless, no significant differences were observed among the AV and TC groups. Also these parameters were not significantly different among the S, V and control groups.

Bottom Line: Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science.The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats.Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy and Cell Biology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

ABSTRACT
Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science. The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats. In a randomized controlled trial, thirty-six Wistar male rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05). Topical administration of Aloe vera gel is recommended as the treatment of choice for surgical incisions.

No MeSH data available.


Related in: MedlinePlus