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Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats.

Tarameshloo M, Norouzian M, Zarein-Dolab S, Dadpay M, Mohsenifar J, Gazor R - Anat Cell Biol (2012)

Bottom Line: Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science.The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats.Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy and Cell Biology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

ABSTRACT
Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science. The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats. In a randomized controlled trial, thirty-six Wistar male rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05). Topical administration of Aloe vera gel is recommended as the treatment of choice for surgical incisions.

No MeSH data available.


Related in: MedlinePlus

Diagram of the wounds model.
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Figure 1: Diagram of the wounds model.

Mentions: The wounds in the experimental rats were treated with: AV, TC, SSD 1% (S), or V. The wounds in the control group received no medications (Fig. 1). The treatments were initiated on day 0 and were applied daily for 14 days. To investigate the process of wound healing, the animals in each group were sacrificed on days 4, 7 and 14 (6 rats on each day).


Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats.

Tarameshloo M, Norouzian M, Zarein-Dolab S, Dadpay M, Mohsenifar J, Gazor R - Anat Cell Biol (2012)

Diagram of the wounds model.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472143&req=5

Figure 1: Diagram of the wounds model.
Mentions: The wounds in the experimental rats were treated with: AV, TC, SSD 1% (S), or V. The wounds in the control group received no medications (Fig. 1). The treatments were initiated on day 0 and were applied daily for 14 days. To investigate the process of wound healing, the animals in each group were sacrificed on days 4, 7 and 14 (6 rats on each day).

Bottom Line: Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science.The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats.Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy and Cell Biology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

ABSTRACT
Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science. The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats. In a randomized controlled trial, thirty-six Wistar male rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05). Topical administration of Aloe vera gel is recommended as the treatment of choice for surgical incisions.

No MeSH data available.


Related in: MedlinePlus