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Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer.

Storr SJ, Safuan S, Woolston CM, Abdel-Fatah T, Deen S, Chan SY, Martin SG - J. Cell. Mol. Med. (2012)

Bottom Line: High levels of calpain-2 expression was significantly associated with platinum resistant tumours (P = 0.031).Furthermore, high expression of calpain-2 was significantly associated with progression-free (P = 0.049) and overall survival (P = 0.006) in this cohort.The association between calpain-2 expression and overall survival remained significant in multivariate analysis accounting for tumour grade, stage, optimal debulking and platinum sensitivity (hazard ratio = 2.174; 95% confidence interval = 1.144-4.130; P = 0.018).

View Article: PubMed Central - PubMed

Affiliation: Academic Oncology, University of Nottingham, School of Molecular Medical Sciences, Nottingham University Hospitals NHS Trust, Nottingham, UK.

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Kaplan–Meier analysis of overall survival showing the impact of calpastatin (A), calpain-1 (B) and calpain-2 (C) expression in cohort of 154 patients with significance determined using the log rank test. (A) low expression group has 38 observations and 19 events and high expression group has 80 observations and 37 events; (B) low expression group has 19 observations and 10 events and high expression group has 99 observations and 45 events; (C) low expression group has 40 observations and 13 events and high expression group has 78 observations and 44 events; where observations are the number of observations per group and events are those patients who died.
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fig03: Kaplan–Meier analysis of overall survival showing the impact of calpastatin (A), calpain-1 (B) and calpain-2 (C) expression in cohort of 154 patients with significance determined using the log rank test. (A) low expression group has 38 observations and 19 events and high expression group has 80 observations and 37 events; (B) low expression group has 19 observations and 10 events and high expression group has 99 observations and 45 events; (C) low expression group has 40 observations and 13 events and high expression group has 78 observations and 44 events; where observations are the number of observations per group and events are those patients who died.

Mentions: At the end of the follow-up period 79 patients had died, with a median survival of 35 months. The expression of calpastatin and calpain-1 was not associated with overall survival (Fig. 3A and B). High expression of calpain-2 was significantly associated with overall survival (P = 0.006) (Fig. 3C). In multivariate analysis, including grade, stage, optimal debulking and platinum sensitivity, calpain-2 expression was independently significant for overall survival (hazard ratio = 2.174; 95% confidence interval = 1.144–4.130; P = 0.018) (Table 2B). Tumour grade, stage, optimal debulking and platinum sensitivity were included in multivariate analysis following assessment using the Kaplan–Meier method and significance determined using the log-rank test with individual values of P = 0.008, P < 0.001, P < 0.001 and P < 0.001 respectively.


Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer.

Storr SJ, Safuan S, Woolston CM, Abdel-Fatah T, Deen S, Chan SY, Martin SG - J. Cell. Mol. Med. (2012)

Kaplan–Meier analysis of overall survival showing the impact of calpastatin (A), calpain-1 (B) and calpain-2 (C) expression in cohort of 154 patients with significance determined using the log rank test. (A) low expression group has 38 observations and 19 events and high expression group has 80 observations and 37 events; (B) low expression group has 19 observations and 10 events and high expression group has 99 observations and 45 events; (C) low expression group has 40 observations and 13 events and high expression group has 78 observations and 44 events; where observations are the number of observations per group and events are those patients who died.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3472029&req=5

fig03: Kaplan–Meier analysis of overall survival showing the impact of calpastatin (A), calpain-1 (B) and calpain-2 (C) expression in cohort of 154 patients with significance determined using the log rank test. (A) low expression group has 38 observations and 19 events and high expression group has 80 observations and 37 events; (B) low expression group has 19 observations and 10 events and high expression group has 99 observations and 45 events; (C) low expression group has 40 observations and 13 events and high expression group has 78 observations and 44 events; where observations are the number of observations per group and events are those patients who died.
Mentions: At the end of the follow-up period 79 patients had died, with a median survival of 35 months. The expression of calpastatin and calpain-1 was not associated with overall survival (Fig. 3A and B). High expression of calpain-2 was significantly associated with overall survival (P = 0.006) (Fig. 3C). In multivariate analysis, including grade, stage, optimal debulking and platinum sensitivity, calpain-2 expression was independently significant for overall survival (hazard ratio = 2.174; 95% confidence interval = 1.144–4.130; P = 0.018) (Table 2B). Tumour grade, stage, optimal debulking and platinum sensitivity were included in multivariate analysis following assessment using the Kaplan–Meier method and significance determined using the log-rank test with individual values of P = 0.008, P < 0.001, P < 0.001 and P < 0.001 respectively.

Bottom Line: High levels of calpain-2 expression was significantly associated with platinum resistant tumours (P = 0.031).Furthermore, high expression of calpain-2 was significantly associated with progression-free (P = 0.049) and overall survival (P = 0.006) in this cohort.The association between calpain-2 expression and overall survival remained significant in multivariate analysis accounting for tumour grade, stage, optimal debulking and platinum sensitivity (hazard ratio = 2.174; 95% confidence interval = 1.144-4.130; P = 0.018).

View Article: PubMed Central - PubMed

Affiliation: Academic Oncology, University of Nottingham, School of Molecular Medical Sciences, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Show MeSH
Related in: MedlinePlus