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Seroprevalence of measles-, mumps- and rubella-specific IgG antibodies in German children and adolescents and predictors for seronegativity.

Poethko-Müller C, Mankertz A - PLoS ONE (2012)

Bottom Line: Search for predictors of missing seroprevalence identified young age to be the most important predictor.For mumps, high differences were observed for seronegativity after one-dose and two-dose vaccination, respectively.Seronegativity increases as time since last vaccination passes thus indicating significant waning effects for all three components of MMR.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Health Reporting, Robert Koch Institute, Berlin, Germany. poethko-muellerc@rki.de

ABSTRACT
We have undertaken a seroprevalence study with more than 13,000 children, who had been included in the German KIGGS survey, a representative sample of children and adolescents 0-17 years of age. The IgG titres against measles, mumps and rubella were determined in 1 to 17 year olds While 88.8% of the children were MMR-vaccinated at least once, 76.8% of children aged 1 to 17 years showed prevalence of antibodies to MMR. The highest seronegativity was seen with respect to mumps. Gender differences were most pronounced with regard to rubella IgG titres: girls aged 14 to 17 years were best protected, although seronegativity in 6.8% of this vulnerable group still shows the need of improvement. Search for predictors of missing seroprevalence identified young age to be the most important predictor. Children living in the former West and children born outside of Germany had a higher risk of lacking protection against measles and rubella, while children with a migration background but born in Germany were less often seronegative to measles antibodies than their German contemporaries. An association of seronegativity and early vaccination was seen for measles but not for mumps and rubella. A high maternal educational level was associated with seronegativity to measles and rubella. In vaccinated children, seronegativity was highest for mumps and lowest for rubella. For mumps, high differences were observed for seronegativity after one-dose and two-dose vaccination, respectively. Seronegativity increases as time since last vaccination passes thus indicating significant waning effects for all three components of MMR.

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Prevalence of negative and equivocal Measles IgG antibody titres by age and gender.
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pone-0042867-g003: Prevalence of negative and equivocal Measles IgG antibody titres by age and gender.

Mentions: Overall, the highest level of seronegativity was seen with regard to mumps specific antibodies (15.3%; 95% CI 14.4–16.3) (Figure 2) and also the prevalence of children with equivocal titre level was higher for mumps antibodies than for measles (Figure 3) and rubella (Figure 4) antibodies. Some differences for gender and age were seen: In general, girls had a lower rate of seronegativity although this pattern was not seen in 3–6 year olds. The effect was more pronounced for rubella titres, especially in 11–17 year old boys. In 11–13 year old girls, rubella seronegativity of was, on average, 9.1% (95% CI 7.4–11.3) whereas in boys the proportion was 12.8% (95% CI 10.7–15.2). Differences were even more pronounced between 14–17 year old girls and boys with 6.8% (95% CI 5.3–8.7) and 12.6% (95% CI 10.8–14.6), respectively.


Seroprevalence of measles-, mumps- and rubella-specific IgG antibodies in German children and adolescents and predictors for seronegativity.

Poethko-Müller C, Mankertz A - PLoS ONE (2012)

Prevalence of negative and equivocal Measles IgG antibody titres by age and gender.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3412821&req=5

pone-0042867-g003: Prevalence of negative and equivocal Measles IgG antibody titres by age and gender.
Mentions: Overall, the highest level of seronegativity was seen with regard to mumps specific antibodies (15.3%; 95% CI 14.4–16.3) (Figure 2) and also the prevalence of children with equivocal titre level was higher for mumps antibodies than for measles (Figure 3) and rubella (Figure 4) antibodies. Some differences for gender and age were seen: In general, girls had a lower rate of seronegativity although this pattern was not seen in 3–6 year olds. The effect was more pronounced for rubella titres, especially in 11–17 year old boys. In 11–13 year old girls, rubella seronegativity of was, on average, 9.1% (95% CI 7.4–11.3) whereas in boys the proportion was 12.8% (95% CI 10.7–15.2). Differences were even more pronounced between 14–17 year old girls and boys with 6.8% (95% CI 5.3–8.7) and 12.6% (95% CI 10.8–14.6), respectively.

Bottom Line: Search for predictors of missing seroprevalence identified young age to be the most important predictor.For mumps, high differences were observed for seronegativity after one-dose and two-dose vaccination, respectively.Seronegativity increases as time since last vaccination passes thus indicating significant waning effects for all three components of MMR.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Health Reporting, Robert Koch Institute, Berlin, Germany. poethko-muellerc@rki.de

ABSTRACT
We have undertaken a seroprevalence study with more than 13,000 children, who had been included in the German KIGGS survey, a representative sample of children and adolescents 0-17 years of age. The IgG titres against measles, mumps and rubella were determined in 1 to 17 year olds While 88.8% of the children were MMR-vaccinated at least once, 76.8% of children aged 1 to 17 years showed prevalence of antibodies to MMR. The highest seronegativity was seen with respect to mumps. Gender differences were most pronounced with regard to rubella IgG titres: girls aged 14 to 17 years were best protected, although seronegativity in 6.8% of this vulnerable group still shows the need of improvement. Search for predictors of missing seroprevalence identified young age to be the most important predictor. Children living in the former West and children born outside of Germany had a higher risk of lacking protection against measles and rubella, while children with a migration background but born in Germany were less often seronegative to measles antibodies than their German contemporaries. An association of seronegativity and early vaccination was seen for measles but not for mumps and rubella. A high maternal educational level was associated with seronegativity to measles and rubella. In vaccinated children, seronegativity was highest for mumps and lowest for rubella. For mumps, high differences were observed for seronegativity after one-dose and two-dose vaccination, respectively. Seronegativity increases as time since last vaccination passes thus indicating significant waning effects for all three components of MMR.

Show MeSH
Related in: MedlinePlus