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The cortical signature of amyotrophic lateral sclerosis.

Agosta F, Valsasina P, Riva N, Copetti M, Messina MJ, Prelle A, Comi G, Filippi M - PLoS ONE (2012)

Bottom Line: Group differences in cortical thickness and the age-by-group effects were assessed using vertex-by-vertex and multivariate linear models.There was a significant age-by-group effect in the sensorimotor cortices bilaterally, suggesting a stronger association between age and cortical thinning in ALS patients compared to controls.Cortical thickness measurements allowed the detection and quantification of motor and extramotor involvement in patients with ALS.

View Article: PubMed Central - PubMed

Affiliation: Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

ABSTRACT
The aim of this study was to explore the pattern of regional cortical thickness in patients with non-familial amyotrophic lateral sclerosis (ALS) and to investigate whether cortical thinning is associated with disease progression rate. Cortical thickness analysis was performed in 44 ALS patients and 26 healthy controls. Group differences in cortical thickness and the age-by-group effects were assessed using vertex-by-vertex and multivariate linear models. The discriminatory ability of MRI variables in distinguishing patients from controls was estimated using the Concordance Statistics (C-statistic) within logistic regression analyses. Correlations between cortical thickness measures and disease progression rate were tested using the Pearson coefficient. Relative to controls, ALS patients showed a bilateral cortical thinning of the primary motor, prefrontal and ventral frontal cortices, cingulate gyrus, insula, superior and inferior temporal and parietal regions, and medial and lateral occipital areas. There was a significant age-by-group effect in the sensorimotor cortices bilaterally, suggesting a stronger association between age and cortical thinning in ALS patients compared to controls. The mean cortical thickness of the sensorimotor cortices distinguished patients with ALS from controls (C-statistic ≥ 0.74). Cortical thinning of the left sensorimotor cortices was related to a faster clinical progression (r = -0.33, p = 0.03). Cortical thickness measurements allowed the detection and quantification of motor and extramotor involvement in patients with ALS. Cortical thinning of the precentral gyrus might offer a marker of upper motor neuron involvement and disease progression.

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Related in: MedlinePlus

Relationship between cortical thickness and age.Top: vertex-by-vertex analysis; regions of significant age-by-group interaction with cortical thickness. Color bar represents t values (p<0.05). Bottom: scatterplots of the correlations between the cortical thickness measures and subject age in patients with amyotrophic lateral sclerosis (blue circles) and healthy controls (red squares).
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pone-0042816-g003: Relationship between cortical thickness and age.Top: vertex-by-vertex analysis; regions of significant age-by-group interaction with cortical thickness. Color bar represents t values (p<0.05). Bottom: scatterplots of the correlations between the cortical thickness measures and subject age in patients with amyotrophic lateral sclerosis (blue circles) and healthy controls (red squares).

Mentions: The vertex-by-vertex analysis showed that there was a significant age-by-group interaction in the superior part of the left precentral sulcus (x −31, y −10, z 48; p = 0.05, uncorrected for multiple comparisons), and right precentral gyrus (x 48, y −49, z 9; p = 0.05, uncorrected for multiple comparisons) (Figure 3). The significant age-by-group interaction between cortical thickness measures and age was confirmed by the correlation analysis, which showed a stronger association in ALS patients relative to controls between age and mean cortical thickness of the left (heterogeneity p = 0.10; ALS r = −0.66, p<0.0001; controls r = −0.23, p = 0.26) and right (heterogeneity p = 0.09; ALS r = −0.61, p<0.0001; controls r = −0.24, p = 0.24) sensorimotor masks, and right cognitive temporal mask (heterogeneity p = 0.11; ALS r = −0.57, p<0.0001; controls r = −0.23, p = 0.26).


The cortical signature of amyotrophic lateral sclerosis.

Agosta F, Valsasina P, Riva N, Copetti M, Messina MJ, Prelle A, Comi G, Filippi M - PLoS ONE (2012)

Relationship between cortical thickness and age.Top: vertex-by-vertex analysis; regions of significant age-by-group interaction with cortical thickness. Color bar represents t values (p<0.05). Bottom: scatterplots of the correlations between the cortical thickness measures and subject age in patients with amyotrophic lateral sclerosis (blue circles) and healthy controls (red squares).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3412820&req=5

pone-0042816-g003: Relationship between cortical thickness and age.Top: vertex-by-vertex analysis; regions of significant age-by-group interaction with cortical thickness. Color bar represents t values (p<0.05). Bottom: scatterplots of the correlations between the cortical thickness measures and subject age in patients with amyotrophic lateral sclerosis (blue circles) and healthy controls (red squares).
Mentions: The vertex-by-vertex analysis showed that there was a significant age-by-group interaction in the superior part of the left precentral sulcus (x −31, y −10, z 48; p = 0.05, uncorrected for multiple comparisons), and right precentral gyrus (x 48, y −49, z 9; p = 0.05, uncorrected for multiple comparisons) (Figure 3). The significant age-by-group interaction between cortical thickness measures and age was confirmed by the correlation analysis, which showed a stronger association in ALS patients relative to controls between age and mean cortical thickness of the left (heterogeneity p = 0.10; ALS r = −0.66, p<0.0001; controls r = −0.23, p = 0.26) and right (heterogeneity p = 0.09; ALS r = −0.61, p<0.0001; controls r = −0.24, p = 0.24) sensorimotor masks, and right cognitive temporal mask (heterogeneity p = 0.11; ALS r = −0.57, p<0.0001; controls r = −0.23, p = 0.26).

Bottom Line: Group differences in cortical thickness and the age-by-group effects were assessed using vertex-by-vertex and multivariate linear models.There was a significant age-by-group effect in the sensorimotor cortices bilaterally, suggesting a stronger association between age and cortical thinning in ALS patients compared to controls.Cortical thickness measurements allowed the detection and quantification of motor and extramotor involvement in patients with ALS.

View Article: PubMed Central - PubMed

Affiliation: Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

ABSTRACT
The aim of this study was to explore the pattern of regional cortical thickness in patients with non-familial amyotrophic lateral sclerosis (ALS) and to investigate whether cortical thinning is associated with disease progression rate. Cortical thickness analysis was performed in 44 ALS patients and 26 healthy controls. Group differences in cortical thickness and the age-by-group effects were assessed using vertex-by-vertex and multivariate linear models. The discriminatory ability of MRI variables in distinguishing patients from controls was estimated using the Concordance Statistics (C-statistic) within logistic regression analyses. Correlations between cortical thickness measures and disease progression rate were tested using the Pearson coefficient. Relative to controls, ALS patients showed a bilateral cortical thinning of the primary motor, prefrontal and ventral frontal cortices, cingulate gyrus, insula, superior and inferior temporal and parietal regions, and medial and lateral occipital areas. There was a significant age-by-group effect in the sensorimotor cortices bilaterally, suggesting a stronger association between age and cortical thinning in ALS patients compared to controls. The mean cortical thickness of the sensorimotor cortices distinguished patients with ALS from controls (C-statistic ≥ 0.74). Cortical thinning of the left sensorimotor cortices was related to a faster clinical progression (r = -0.33, p = 0.03). Cortical thickness measurements allowed the detection and quantification of motor and extramotor involvement in patients with ALS. Cortical thinning of the precentral gyrus might offer a marker of upper motor neuron involvement and disease progression.

Show MeSH
Related in: MedlinePlus