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The cortical signature of amyotrophic lateral sclerosis.

Agosta F, Valsasina P, Riva N, Copetti M, Messina MJ, Prelle A, Comi G, Filippi M - PLoS ONE (2012)

Bottom Line: Group differences in cortical thickness and the age-by-group effects were assessed using vertex-by-vertex and multivariate linear models.There was a significant age-by-group effect in the sensorimotor cortices bilaterally, suggesting a stronger association between age and cortical thinning in ALS patients compared to controls.Cortical thickness measurements allowed the detection and quantification of motor and extramotor involvement in patients with ALS.

View Article: PubMed Central - PubMed

Affiliation: Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

ABSTRACT
The aim of this study was to explore the pattern of regional cortical thickness in patients with non-familial amyotrophic lateral sclerosis (ALS) and to investigate whether cortical thinning is associated with disease progression rate. Cortical thickness analysis was performed in 44 ALS patients and 26 healthy controls. Group differences in cortical thickness and the age-by-group effects were assessed using vertex-by-vertex and multivariate linear models. The discriminatory ability of MRI variables in distinguishing patients from controls was estimated using the Concordance Statistics (C-statistic) within logistic regression analyses. Correlations between cortical thickness measures and disease progression rate were tested using the Pearson coefficient. Relative to controls, ALS patients showed a bilateral cortical thinning of the primary motor, prefrontal and ventral frontal cortices, cingulate gyrus, insula, superior and inferior temporal and parietal regions, and medial and lateral occipital areas. There was a significant age-by-group effect in the sensorimotor cortices bilaterally, suggesting a stronger association between age and cortical thinning in ALS patients compared to controls. The mean cortical thickness of the sensorimotor cortices distinguished patients with ALS from controls (C-statistic ≥ 0.74). Cortical thinning of the left sensorimotor cortices was related to a faster clinical progression (r = -0.33, p = 0.03). Cortical thickness measurements allowed the detection and quantification of motor and extramotor involvement in patients with ALS. Cortical thinning of the precentral gyrus might offer a marker of upper motor neuron involvement and disease progression.

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Vertex-by-vertex analysis: regions of significantly thinner cortex in patients with amyotrophic lateral sclerosis compared with healthy controls represented on an averaged brain map.Color bar represents t values (p<0.05, uncorrected for multiple comparisons).
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pone-0042816-g001: Vertex-by-vertex analysis: regions of significantly thinner cortex in patients with amyotrophic lateral sclerosis compared with healthy controls represented on an averaged brain map.Color bar represents t values (p<0.05, uncorrected for multiple comparisons).

Mentions: Whole brain, vertex-by-vertex analysis showed that, compared with controls, ALS patients had a thinning of the left superior part of the precentral sulcus (x −31, y −10, z 49; p = 0.05), left paracentral gyrus (x −18, y −44, z 72; p = 0.01), and right precentral gyrus (x 56, y −1, z 39; p = 0.05) (p<0.05, uncorrected for multiple comparisons; Figure 1). The results did not change when the analysis was performed in limb-onset ALS patients compared with healthy controls (data not shown).


The cortical signature of amyotrophic lateral sclerosis.

Agosta F, Valsasina P, Riva N, Copetti M, Messina MJ, Prelle A, Comi G, Filippi M - PLoS ONE (2012)

Vertex-by-vertex analysis: regions of significantly thinner cortex in patients with amyotrophic lateral sclerosis compared with healthy controls represented on an averaged brain map.Color bar represents t values (p<0.05, uncorrected for multiple comparisons).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3412820&req=5

pone-0042816-g001: Vertex-by-vertex analysis: regions of significantly thinner cortex in patients with amyotrophic lateral sclerosis compared with healthy controls represented on an averaged brain map.Color bar represents t values (p<0.05, uncorrected for multiple comparisons).
Mentions: Whole brain, vertex-by-vertex analysis showed that, compared with controls, ALS patients had a thinning of the left superior part of the precentral sulcus (x −31, y −10, z 49; p = 0.05), left paracentral gyrus (x −18, y −44, z 72; p = 0.01), and right precentral gyrus (x 56, y −1, z 39; p = 0.05) (p<0.05, uncorrected for multiple comparisons; Figure 1). The results did not change when the analysis was performed in limb-onset ALS patients compared with healthy controls (data not shown).

Bottom Line: Group differences in cortical thickness and the age-by-group effects were assessed using vertex-by-vertex and multivariate linear models.There was a significant age-by-group effect in the sensorimotor cortices bilaterally, suggesting a stronger association between age and cortical thinning in ALS patients compared to controls.Cortical thickness measurements allowed the detection and quantification of motor and extramotor involvement in patients with ALS.

View Article: PubMed Central - PubMed

Affiliation: Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

ABSTRACT
The aim of this study was to explore the pattern of regional cortical thickness in patients with non-familial amyotrophic lateral sclerosis (ALS) and to investigate whether cortical thinning is associated with disease progression rate. Cortical thickness analysis was performed in 44 ALS patients and 26 healthy controls. Group differences in cortical thickness and the age-by-group effects were assessed using vertex-by-vertex and multivariate linear models. The discriminatory ability of MRI variables in distinguishing patients from controls was estimated using the Concordance Statistics (C-statistic) within logistic regression analyses. Correlations between cortical thickness measures and disease progression rate were tested using the Pearson coefficient. Relative to controls, ALS patients showed a bilateral cortical thinning of the primary motor, prefrontal and ventral frontal cortices, cingulate gyrus, insula, superior and inferior temporal and parietal regions, and medial and lateral occipital areas. There was a significant age-by-group effect in the sensorimotor cortices bilaterally, suggesting a stronger association between age and cortical thinning in ALS patients compared to controls. The mean cortical thickness of the sensorimotor cortices distinguished patients with ALS from controls (C-statistic ≥ 0.74). Cortical thinning of the left sensorimotor cortices was related to a faster clinical progression (r = -0.33, p = 0.03). Cortical thickness measurements allowed the detection and quantification of motor and extramotor involvement in patients with ALS. Cortical thinning of the precentral gyrus might offer a marker of upper motor neuron involvement and disease progression.

Show MeSH
Related in: MedlinePlus