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Association between FGFR1OP2/wit3.0 polymorphisms and residual ridge resorption of mandible in Korean population.

Kim JH, Oh MY, Paek J, Lee J - PLoS ONE (2012)

Bottom Line: The present study represents an attempt to replicate the results of this previous study and to examine the genetic association between polymorphisms in FGFR1OP2 and residual ridge resorption of mandible in a Korean population. 134 subjects (70.46 ± 9.02 years) with partially or completely edentulous mandible were recruited.SNP rs840869 was not associated with residual ridge resorption (p = 0.479).The bone height of the subject with the ss518063493 minor allele (8.52 mm) was shorter than that of those subjects with major alleles (18.96 ± 5.33 mm, p = 0.053).

View Article: PubMed Central - PubMed

Affiliation: Department of Prosthodontics, College of Dentistry, Yonsei University, Seoul, Korea.

ABSTRACT

Background: A previous study on the genetic association between single nucleotide polymorphisms in FGFR1OP2/wit3.0 and the long term atrophy of edentulous mandible hypothesized that the excessive jawbone atrophy after dental extraction may be associated with abnormal oral mucosa contraction induced by the FGFR1OP2/wit 3.0 gene. It was reported that the minor allele of rs840869 or rs859024 in FGFR1OP2/wit3.0 was associated with the excessive atrophy of edentulous mandible. The present study represents an attempt to replicate the results of this previous study and to examine the genetic association between polymorphisms in FGFR1OP2 and residual ridge resorption of mandible in a Korean population.

Methodology/principal findings: 134 subjects (70.46 ± 9.02 years) with partially or completely edentulous mandible were recruited. The mandibular bone height was measured following the protocol of the American College of Prosthodontists (ACP). From 24 subjects, seven variants in FGFR1OP2 were discovered and four of them were novel. Selected SNPs that are not in high LD at r2 threshold of 0.8 were genotyped for the remaining population. There was no frequency of the minor allele of SNP rs859024 in Korean population. SNP rs840869 was not associated with residual ridge resorption (p = 0.479). The bone height of the subject with the ss518063493 minor allele (8.52 mm) was shorter than that of those subjects with major alleles (18.96 ± 5.33 mm, p = 0.053).

Conclusions/significance: The patient with minor allele of ss518063493 may be associated with excessive atrophy of edentulous mandible whereas the patients with that of rs840869 are not associated in Korean population. The result from this study may assist in developing a novel genetic diagnostic test and be useful in identifying Koreans susceptible to developing excessive jawbone atrophy after dental extraction.

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Related in: MedlinePlus

Characterization of mandibular ridge.A. Panoramic dental radiographs were used to determine the lowest residual ridge height (arrow) of edentulous mandible. Figure on the right indicates severe atrophy of edentulous mandible. B. Scatter plot of mandibular residual ridge height (n = 134). C. All subjects fell into one of the following ACP classifications: Type I (n = 53); Type II (n = 46); Type III (n = 24); Type IV (n = 11).
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pone-0042734-g001: Characterization of mandibular ridge.A. Panoramic dental radiographs were used to determine the lowest residual ridge height (arrow) of edentulous mandible. Figure on the right indicates severe atrophy of edentulous mandible. B. Scatter plot of mandibular residual ridge height (n = 134). C. All subjects fell into one of the following ACP classifications: Type I (n = 53); Type II (n = 46); Type III (n = 24); Type IV (n = 11).

Mentions: The panoramic dental radiograph of each subject was assigned an anonymous identification number and stored in a secured computer with password protection. The lowest height of the edentulous mandible was measured according to the Prothodontic Diagnosis Index classification from the American College of Prosthodontists (ACP) (Figure 1A). The mean mandibular bone height was 18.92±5.45 mm (n = 134) and it varied from 8.52 mm to 32.34 mm (Figure 1B).The ACP classification is as follows: Type I: residual ridge bone height of 21 mm or greater; Type II: residual ridge bone height of 16 to 20 mm; Type III: residual ridge bone height of 11 to 15 mm; and Type IV: residual ridge bone height of 10 mm or less. [24] Of our subjects, 53 were classified as Type I (mean residual ridge bone height 24.38±2.46 mm); 46 as Type II (18.06±1.69 mm); 24 as Type III (12.72±1.21 mm); and 11 as Type IV (9.75±0.65 mm) (Figure 1C).


Association between FGFR1OP2/wit3.0 polymorphisms and residual ridge resorption of mandible in Korean population.

Kim JH, Oh MY, Paek J, Lee J - PLoS ONE (2012)

Characterization of mandibular ridge.A. Panoramic dental radiographs were used to determine the lowest residual ridge height (arrow) of edentulous mandible. Figure on the right indicates severe atrophy of edentulous mandible. B. Scatter plot of mandibular residual ridge height (n = 134). C. All subjects fell into one of the following ACP classifications: Type I (n = 53); Type II (n = 46); Type III (n = 24); Type IV (n = 11).
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Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3412816&req=5

pone-0042734-g001: Characterization of mandibular ridge.A. Panoramic dental radiographs were used to determine the lowest residual ridge height (arrow) of edentulous mandible. Figure on the right indicates severe atrophy of edentulous mandible. B. Scatter plot of mandibular residual ridge height (n = 134). C. All subjects fell into one of the following ACP classifications: Type I (n = 53); Type II (n = 46); Type III (n = 24); Type IV (n = 11).
Mentions: The panoramic dental radiograph of each subject was assigned an anonymous identification number and stored in a secured computer with password protection. The lowest height of the edentulous mandible was measured according to the Prothodontic Diagnosis Index classification from the American College of Prosthodontists (ACP) (Figure 1A). The mean mandibular bone height was 18.92±5.45 mm (n = 134) and it varied from 8.52 mm to 32.34 mm (Figure 1B).The ACP classification is as follows: Type I: residual ridge bone height of 21 mm or greater; Type II: residual ridge bone height of 16 to 20 mm; Type III: residual ridge bone height of 11 to 15 mm; and Type IV: residual ridge bone height of 10 mm or less. [24] Of our subjects, 53 were classified as Type I (mean residual ridge bone height 24.38±2.46 mm); 46 as Type II (18.06±1.69 mm); 24 as Type III (12.72±1.21 mm); and 11 as Type IV (9.75±0.65 mm) (Figure 1C).

Bottom Line: The present study represents an attempt to replicate the results of this previous study and to examine the genetic association between polymorphisms in FGFR1OP2 and residual ridge resorption of mandible in a Korean population. 134 subjects (70.46 ± 9.02 years) with partially or completely edentulous mandible were recruited.SNP rs840869 was not associated with residual ridge resorption (p = 0.479).The bone height of the subject with the ss518063493 minor allele (8.52 mm) was shorter than that of those subjects with major alleles (18.96 ± 5.33 mm, p = 0.053).

View Article: PubMed Central - PubMed

Affiliation: Department of Prosthodontics, College of Dentistry, Yonsei University, Seoul, Korea.

ABSTRACT

Background: A previous study on the genetic association between single nucleotide polymorphisms in FGFR1OP2/wit3.0 and the long term atrophy of edentulous mandible hypothesized that the excessive jawbone atrophy after dental extraction may be associated with abnormal oral mucosa contraction induced by the FGFR1OP2/wit 3.0 gene. It was reported that the minor allele of rs840869 or rs859024 in FGFR1OP2/wit3.0 was associated with the excessive atrophy of edentulous mandible. The present study represents an attempt to replicate the results of this previous study and to examine the genetic association between polymorphisms in FGFR1OP2 and residual ridge resorption of mandible in a Korean population.

Methodology/principal findings: 134 subjects (70.46 ± 9.02 years) with partially or completely edentulous mandible were recruited. The mandibular bone height was measured following the protocol of the American College of Prosthodontists (ACP). From 24 subjects, seven variants in FGFR1OP2 were discovered and four of them were novel. Selected SNPs that are not in high LD at r2 threshold of 0.8 were genotyped for the remaining population. There was no frequency of the minor allele of SNP rs859024 in Korean population. SNP rs840869 was not associated with residual ridge resorption (p = 0.479). The bone height of the subject with the ss518063493 minor allele (8.52 mm) was shorter than that of those subjects with major alleles (18.96 ± 5.33 mm, p = 0.053).

Conclusions/significance: The patient with minor allele of ss518063493 may be associated with excessive atrophy of edentulous mandible whereas the patients with that of rs840869 are not associated in Korean population. The result from this study may assist in developing a novel genetic diagnostic test and be useful in identifying Koreans susceptible to developing excessive jawbone atrophy after dental extraction.

Show MeSH
Related in: MedlinePlus