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The effect of exercise training modality on serum brain derived neurotrophic factor levels in individuals with type 2 diabetes.

Swift DL, Johannsen NM, Myers VH, Earnest CP, Smits JA, Blair SN, Church TS - PLoS ONE (2012)

Bottom Line: However, reductions in waist circumference were directly associated with changes in serum BDNF following training (r = 0.25, p = 0.005).Serum BDNF was not associated with fitness, body composition, anthropometry, glucose control, or strength measures at baseline.However, reductions in waist circumference were associated with decreased serum BDNF levels.

View Article: PubMed Central - PubMed

Affiliation: Department of Preventive Medicine, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.

ABSTRACT

Introduction: Brain derived neurotrophic factor (BDNF) has been implicated in memory, learning, and neurodegenerative diseases. However, the relationship of BDNF with cardiometabolic risk factors is unclear, and the effect of exercise training on BDNF has not been previously explored in individuals with type 2 diabetes.

Methods: Men and women (N = 150) with type 2 diabetes were randomized to an aerobic exercise (aerobic), resistance exercise (resistance), or a combination of both (combination) for 9 months. Serum BDNF levels were evaluated at baseline and follow-up from archived blood samples.

Results: Baseline serum BDNF was not associated with fitness, body composition, anthropometry, glucose control, or strength measures (all, p>0.05). Similarly, no significant change in serum BDNF levels was observed following exercise training in the aerobic (-1649.4 pg/ml, CI: -4768.9 to 1470.2), resistance (-2351.2 pg/ml, CI:-5290.7 to 588.3), or combination groups (-827.4 pg/ml, CI: -3533.3 to 1878.5) compared to the control group (-2320.0 pg/ml, CI: -5750.8 to 1110.8). However, reductions in waist circumference were directly associated with changes in serum BDNF following training (r = 0.25, p = 0.005).

Conclusions: Serum BDNF was not associated with fitness, body composition, anthropometry, glucose control, or strength measures at baseline. Likewise, serum BDNF measures were not altered by 9 months of aerobic, resistance, or combination training. However, reductions in waist circumference were associated with decreased serum BDNF levels. Future studies should investigate the relevance of BDNF with measures of cognitive function specifically in individuals with type-2 diabetes.

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The effect of exercise training modality on serum BDNF levels.Results are presented as adjusted least square means with 95% confidence intervals. The statistical model is adjusted for baseline value, age, sex, duration of diabetes, and ethnic group.
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pone-0042785-g002: The effect of exercise training modality on serum BDNF levels.Results are presented as adjusted least square means with 95% confidence intervals. The statistical model is adjusted for baseline value, age, sex, duration of diabetes, and ethnic group.

Mentions: The effects of exercise modality on serum BDNF levels are shown in Figure 2. No significant change in serum BDNF levels was observed following exercise training in the aerobic (−1649.4 pg/ml, CI: −4768.9 to 1470.2), resistance (−2351.2 pg/ml, CI:−5290.7 to 588.3), or combination groups (−827.4 pg/ml, CI: −3533.3 to1878.5) compared to the control group (−2320.0 pg/ml, CI: −5750.8 to 1110.8). Similarly, when the same analysis was performed with outliers included (N = 168), no significant change was observed in serum BDNF levels between the aerobic (−432.9 pg/ml, CI: −432.9 pg/ml, CI: −4413.9 to 3548.2), resistance (−827.9 pg/ml, CI: −4601.9 to 2946.2), and combination groups (−1912.5 pg/ml, CI: −5257.3 to 1432.2) compared to the control group (−3864.1 pg/ml, CI: −8487.3 to −759.2).


The effect of exercise training modality on serum brain derived neurotrophic factor levels in individuals with type 2 diabetes.

Swift DL, Johannsen NM, Myers VH, Earnest CP, Smits JA, Blair SN, Church TS - PLoS ONE (2012)

The effect of exercise training modality on serum BDNF levels.Results are presented as adjusted least square means with 95% confidence intervals. The statistical model is adjusted for baseline value, age, sex, duration of diabetes, and ethnic group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3412800&req=5

pone-0042785-g002: The effect of exercise training modality on serum BDNF levels.Results are presented as adjusted least square means with 95% confidence intervals. The statistical model is adjusted for baseline value, age, sex, duration of diabetes, and ethnic group.
Mentions: The effects of exercise modality on serum BDNF levels are shown in Figure 2. No significant change in serum BDNF levels was observed following exercise training in the aerobic (−1649.4 pg/ml, CI: −4768.9 to 1470.2), resistance (−2351.2 pg/ml, CI:−5290.7 to 588.3), or combination groups (−827.4 pg/ml, CI: −3533.3 to1878.5) compared to the control group (−2320.0 pg/ml, CI: −5750.8 to 1110.8). Similarly, when the same analysis was performed with outliers included (N = 168), no significant change was observed in serum BDNF levels between the aerobic (−432.9 pg/ml, CI: −432.9 pg/ml, CI: −4413.9 to 3548.2), resistance (−827.9 pg/ml, CI: −4601.9 to 2946.2), and combination groups (−1912.5 pg/ml, CI: −5257.3 to 1432.2) compared to the control group (−3864.1 pg/ml, CI: −8487.3 to −759.2).

Bottom Line: However, reductions in waist circumference were directly associated with changes in serum BDNF following training (r = 0.25, p = 0.005).Serum BDNF was not associated with fitness, body composition, anthropometry, glucose control, or strength measures at baseline.However, reductions in waist circumference were associated with decreased serum BDNF levels.

View Article: PubMed Central - PubMed

Affiliation: Department of Preventive Medicine, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.

ABSTRACT

Introduction: Brain derived neurotrophic factor (BDNF) has been implicated in memory, learning, and neurodegenerative diseases. However, the relationship of BDNF with cardiometabolic risk factors is unclear, and the effect of exercise training on BDNF has not been previously explored in individuals with type 2 diabetes.

Methods: Men and women (N = 150) with type 2 diabetes were randomized to an aerobic exercise (aerobic), resistance exercise (resistance), or a combination of both (combination) for 9 months. Serum BDNF levels were evaluated at baseline and follow-up from archived blood samples.

Results: Baseline serum BDNF was not associated with fitness, body composition, anthropometry, glucose control, or strength measures (all, p>0.05). Similarly, no significant change in serum BDNF levels was observed following exercise training in the aerobic (-1649.4 pg/ml, CI: -4768.9 to 1470.2), resistance (-2351.2 pg/ml, CI:-5290.7 to 588.3), or combination groups (-827.4 pg/ml, CI: -3533.3 to 1878.5) compared to the control group (-2320.0 pg/ml, CI: -5750.8 to 1110.8). However, reductions in waist circumference were directly associated with changes in serum BDNF following training (r = 0.25, p = 0.005).

Conclusions: Serum BDNF was not associated with fitness, body composition, anthropometry, glucose control, or strength measures at baseline. Likewise, serum BDNF measures were not altered by 9 months of aerobic, resistance, or combination training. However, reductions in waist circumference were associated with decreased serum BDNF levels. Future studies should investigate the relevance of BDNF with measures of cognitive function specifically in individuals with type-2 diabetes.

Show MeSH
Related in: MedlinePlus