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The effect of exercise training modality on serum brain derived neurotrophic factor levels in individuals with type 2 diabetes.

Swift DL, Johannsen NM, Myers VH, Earnest CP, Smits JA, Blair SN, Church TS - PLoS ONE (2012)

Bottom Line: However, reductions in waist circumference were directly associated with changes in serum BDNF following training (r = 0.25, p = 0.005).Serum BDNF was not associated with fitness, body composition, anthropometry, glucose control, or strength measures at baseline.However, reductions in waist circumference were associated with decreased serum BDNF levels.

View Article: PubMed Central - PubMed

Affiliation: Department of Preventive Medicine, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.

ABSTRACT

Introduction: Brain derived neurotrophic factor (BDNF) has been implicated in memory, learning, and neurodegenerative diseases. However, the relationship of BDNF with cardiometabolic risk factors is unclear, and the effect of exercise training on BDNF has not been previously explored in individuals with type 2 diabetes.

Methods: Men and women (N = 150) with type 2 diabetes were randomized to an aerobic exercise (aerobic), resistance exercise (resistance), or a combination of both (combination) for 9 months. Serum BDNF levels were evaluated at baseline and follow-up from archived blood samples.

Results: Baseline serum BDNF was not associated with fitness, body composition, anthropometry, glucose control, or strength measures (all, p>0.05). Similarly, no significant change in serum BDNF levels was observed following exercise training in the aerobic (-1649.4 pg/ml, CI: -4768.9 to 1470.2), resistance (-2351.2 pg/ml, CI:-5290.7 to 588.3), or combination groups (-827.4 pg/ml, CI: -3533.3 to 1878.5) compared to the control group (-2320.0 pg/ml, CI: -5750.8 to 1110.8). However, reductions in waist circumference were directly associated with changes in serum BDNF following training (r = 0.25, p = 0.005).

Conclusions: Serum BDNF was not associated with fitness, body composition, anthropometry, glucose control, or strength measures at baseline. Likewise, serum BDNF measures were not altered by 9 months of aerobic, resistance, or combination training. However, reductions in waist circumference were associated with decreased serum BDNF levels. Future studies should investigate the relevance of BDNF with measures of cognitive function specifically in individuals with type-2 diabetes.

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pone-0042785-g001: Consort diagram.

Mentions: The full methodology of the exercise training program used in the Health Benefits of Aerobic and Resistance Training in Individuals with Type 2 diabetes (HART-D) has been reported in the main outcomes paper [16]. HART-D was a 9 month exercise study comparing the effects of aerobic training, resistance training, or a combination of both on HbA1C in men and women with type 2 diabetes. The primary outcome measure of this ancillary study is the change in serum BDNF levels following exercise training. From the parent HART-D study of 262 sedentary (30–75 years) adults with type 2 diabetes presenting with an HbA1C of 6.5% to 11.0%, serum BDNF values were examined in a subset of controls and adherent exercisers (n = 168) from which a total of 150 participants were included in the final analysis. A consort diagram is shown in Figure 1. Notable exclusion criteria for the HART-D trial included a body mass index (BMI)>48 kg/m2, blood pressure 160/100 mmHg or higher, fasting triglycerides 500 mg/dL or higher, use of an insulin pump, urine protein greater than 100 mg/dL, history of stroke, advanced neuropathy, retinopathy, or any serious medical condition that prevented adherence to the study protocol or was a contraindication for exercise training. The institutional review board at Pennington Biomedical Research Center approved the protocol annually and all participants provided written informed consent before initiating the any of the study protocols.


The effect of exercise training modality on serum brain derived neurotrophic factor levels in individuals with type 2 diabetes.

Swift DL, Johannsen NM, Myers VH, Earnest CP, Smits JA, Blair SN, Church TS - PLoS ONE (2012)

Consort diagram.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3412800&req=5

pone-0042785-g001: Consort diagram.
Mentions: The full methodology of the exercise training program used in the Health Benefits of Aerobic and Resistance Training in Individuals with Type 2 diabetes (HART-D) has been reported in the main outcomes paper [16]. HART-D was a 9 month exercise study comparing the effects of aerobic training, resistance training, or a combination of both on HbA1C in men and women with type 2 diabetes. The primary outcome measure of this ancillary study is the change in serum BDNF levels following exercise training. From the parent HART-D study of 262 sedentary (30–75 years) adults with type 2 diabetes presenting with an HbA1C of 6.5% to 11.0%, serum BDNF values were examined in a subset of controls and adherent exercisers (n = 168) from which a total of 150 participants were included in the final analysis. A consort diagram is shown in Figure 1. Notable exclusion criteria for the HART-D trial included a body mass index (BMI)>48 kg/m2, blood pressure 160/100 mmHg or higher, fasting triglycerides 500 mg/dL or higher, use of an insulin pump, urine protein greater than 100 mg/dL, history of stroke, advanced neuropathy, retinopathy, or any serious medical condition that prevented adherence to the study protocol or was a contraindication for exercise training. The institutional review board at Pennington Biomedical Research Center approved the protocol annually and all participants provided written informed consent before initiating the any of the study protocols.

Bottom Line: However, reductions in waist circumference were directly associated with changes in serum BDNF following training (r = 0.25, p = 0.005).Serum BDNF was not associated with fitness, body composition, anthropometry, glucose control, or strength measures at baseline.However, reductions in waist circumference were associated with decreased serum BDNF levels.

View Article: PubMed Central - PubMed

Affiliation: Department of Preventive Medicine, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.

ABSTRACT

Introduction: Brain derived neurotrophic factor (BDNF) has been implicated in memory, learning, and neurodegenerative diseases. However, the relationship of BDNF with cardiometabolic risk factors is unclear, and the effect of exercise training on BDNF has not been previously explored in individuals with type 2 diabetes.

Methods: Men and women (N = 150) with type 2 diabetes were randomized to an aerobic exercise (aerobic), resistance exercise (resistance), or a combination of both (combination) for 9 months. Serum BDNF levels were evaluated at baseline and follow-up from archived blood samples.

Results: Baseline serum BDNF was not associated with fitness, body composition, anthropometry, glucose control, or strength measures (all, p>0.05). Similarly, no significant change in serum BDNF levels was observed following exercise training in the aerobic (-1649.4 pg/ml, CI: -4768.9 to 1470.2), resistance (-2351.2 pg/ml, CI:-5290.7 to 588.3), or combination groups (-827.4 pg/ml, CI: -3533.3 to 1878.5) compared to the control group (-2320.0 pg/ml, CI: -5750.8 to 1110.8). However, reductions in waist circumference were directly associated with changes in serum BDNF following training (r = 0.25, p = 0.005).

Conclusions: Serum BDNF was not associated with fitness, body composition, anthropometry, glucose control, or strength measures at baseline. Likewise, serum BDNF measures were not altered by 9 months of aerobic, resistance, or combination training. However, reductions in waist circumference were associated with decreased serum BDNF levels. Future studies should investigate the relevance of BDNF with measures of cognitive function specifically in individuals with type-2 diabetes.

Show MeSH
Related in: MedlinePlus