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HOMA-AD in Assessing Insulin Resistance in Lean Noncirrhotic HCV Outpatients.

Michalczuk MT, Kappel CR, Birkhan O, Bragança AC, Alvares-da-Silva MR - Int J Hepatol (2012)

Bottom Line: No differences were found in adiponectin levels (P = 0.294) and HOMA-AD (P = 0.393).Conclusion.HOMA-AD does not seem to be useful in assessing IR in HCV patients.

View Article: PubMed Central - PubMed

Affiliation: Gastroenterology Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, 90035-003 Porto Alegre, RS, Brazil.

ABSTRACT
Introduction. There is an association between HCV and insulin resistance (IR), which is currently assessed by HOMA-IR. There is evidence that HOMA-adiponectin (HOMA-AD) is more accurate, but its role in HCV patients is unknown. The purpose of this study was to evaluate IR in an HCV sample and controls, in order to compare the accuracy of HOMA-IR and HOMA-AD. Methods. Ninety-four HCV outpatients aged <60 years who met the criteria of nondiabetic, nonobese, noncirrhotic, and nonalcohol abusers were included and compared to 29 controls. Fasting glucose, insulin, adiponectin, and lipid profiles were determined. IR was estimated by HOMA-IR and HOMA-AD. Results. The groups were similar regarding sex and BMI, but the HCV patients were older. The median insulin level was higher in the HCV group (8.6 mU/mL (6.5-13.7) versus 6.5 (4.3-10.7), P = 0.004), as was median HOMA-IR (1.94 (1.51 to 3.48) versus 1.40 (1.02 to 2.36), P = 0.002) and the prevalence of IR (38.3% versus 10.3% (P = 0.009)). No differences were found in adiponectin levels (P = 0.294) and HOMA-AD (P = 0.393). Conclusion. IR is highly prevalent even in low-risk HCV outpatients. Adiponectin is not influenced by the presence of HCV. HOMA-AD does not seem to be useful in assessing IR in HCV patients.

No MeSH data available.


Related in: MedlinePlus

Spearman's correlation coefficient between HOMA-IR and HOMA-AD in the general sample, HCV, and control group.
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fig1: Spearman's correlation coefficient between HOMA-IR and HOMA-AD in the general sample, HCV, and control group.

Mentions: HOMA-IR and HOMA-AD presented a strong correlation as assessed by Spearman's correlation coefficient analysis, varying between 0.652 in the general sample, 0.753 in noninfected individuals and 0.605 in HCV patients (P < 0.001 for all cases, as shown in Figure 1).


HOMA-AD in Assessing Insulin Resistance in Lean Noncirrhotic HCV Outpatients.

Michalczuk MT, Kappel CR, Birkhan O, Bragança AC, Alvares-da-Silva MR - Int J Hepatol (2012)

Spearman's correlation coefficient between HOMA-IR and HOMA-AD in the general sample, HCV, and control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3405643&req=5

fig1: Spearman's correlation coefficient between HOMA-IR and HOMA-AD in the general sample, HCV, and control group.
Mentions: HOMA-IR and HOMA-AD presented a strong correlation as assessed by Spearman's correlation coefficient analysis, varying between 0.652 in the general sample, 0.753 in noninfected individuals and 0.605 in HCV patients (P < 0.001 for all cases, as shown in Figure 1).

Bottom Line: No differences were found in adiponectin levels (P = 0.294) and HOMA-AD (P = 0.393).Conclusion.HOMA-AD does not seem to be useful in assessing IR in HCV patients.

View Article: PubMed Central - PubMed

Affiliation: Gastroenterology Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, 90035-003 Porto Alegre, RS, Brazil.

ABSTRACT
Introduction. There is an association between HCV and insulin resistance (IR), which is currently assessed by HOMA-IR. There is evidence that HOMA-adiponectin (HOMA-AD) is more accurate, but its role in HCV patients is unknown. The purpose of this study was to evaluate IR in an HCV sample and controls, in order to compare the accuracy of HOMA-IR and HOMA-AD. Methods. Ninety-four HCV outpatients aged <60 years who met the criteria of nondiabetic, nonobese, noncirrhotic, and nonalcohol abusers were included and compared to 29 controls. Fasting glucose, insulin, adiponectin, and lipid profiles were determined. IR was estimated by HOMA-IR and HOMA-AD. Results. The groups were similar regarding sex and BMI, but the HCV patients were older. The median insulin level was higher in the HCV group (8.6 mU/mL (6.5-13.7) versus 6.5 (4.3-10.7), P = 0.004), as was median HOMA-IR (1.94 (1.51 to 3.48) versus 1.40 (1.02 to 2.36), P = 0.002) and the prevalence of IR (38.3% versus 10.3% (P = 0.009)). No differences were found in adiponectin levels (P = 0.294) and HOMA-AD (P = 0.393). Conclusion. IR is highly prevalent even in low-risk HCV outpatients. Adiponectin is not influenced by the presence of HCV. HOMA-AD does not seem to be useful in assessing IR in HCV patients.

No MeSH data available.


Related in: MedlinePlus