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Developing models of how cognitive improvements change functioning: mediation, moderation and moderated mediation.

Wykes T, Reeder C, Huddy V, Taylor R, Wood H, Ghirasim N, Kontis D, Landau S - Schizophr. Res. (2012)

Bottom Line: There was evidence of mediation (planning improvement associated with improved work quality).There was no evidence that cognitive flexibility (total Wisconsin Card Sorting Test errors) and working memory (Wechsler Adult Intelligence Scale III digit span) mediated work functioning despite significant effects.Other specific and non-specific effects of CRT and the work programme are likely to account for some of the remaining effect.

View Article: PubMed Central - PubMed

Affiliation: King's College London, Institute of Psychiatry, London SE5 8AF, UK. til.wykes@kcl.ac.uk

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Effect of changes in Zoo Map score (time 2–time 1) on changes in work quality score (time 3–time 1).
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f0005: Effect of changes in Zoo Map score (time 2–time 1) on changes in work quality score (time 3–time 1).

Mentions: The planning score change on WBI (both total and quality change) was significant. A one point improvement in Zoo Map score following CRT leads to 6.1 point improvement on WBI total score at follow-up (95% CI from − 0.6 to 12.7 points, p = 0.07, beta = 0.37) and a 1.58 point improvement on WBI work quality (CI from 0.28 to 2.88 points, p = 0.019, beta = 0.48, Fig. 1).


Developing models of how cognitive improvements change functioning: mediation, moderation and moderated mediation.

Wykes T, Reeder C, Huddy V, Taylor R, Wood H, Ghirasim N, Kontis D, Landau S - Schizophr. Res. (2012)

Effect of changes in Zoo Map score (time 2–time 1) on changes in work quality score (time 3–time 1).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3405533&req=5

f0005: Effect of changes in Zoo Map score (time 2–time 1) on changes in work quality score (time 3–time 1).
Mentions: The planning score change on WBI (both total and quality change) was significant. A one point improvement in Zoo Map score following CRT leads to 6.1 point improvement on WBI total score at follow-up (95% CI from − 0.6 to 12.7 points, p = 0.07, beta = 0.37) and a 1.58 point improvement on WBI work quality (CI from 0.28 to 2.88 points, p = 0.019, beta = 0.48, Fig. 1).

Bottom Line: There was evidence of mediation (planning improvement associated with improved work quality).There was no evidence that cognitive flexibility (total Wisconsin Card Sorting Test errors) and working memory (Wechsler Adult Intelligence Scale III digit span) mediated work functioning despite significant effects.Other specific and non-specific effects of CRT and the work programme are likely to account for some of the remaining effect.

View Article: PubMed Central - PubMed

Affiliation: King's College London, Institute of Psychiatry, London SE5 8AF, UK. til.wykes@kcl.ac.uk

Show MeSH