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Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers.

Bahra M, Kapil V, Pearl V, Ghosh S, Ahluwalia A - Nitric Oxide (2012)

Bottom Line: In addition these changes in [nitrite] were associated with a decrease in systolic BP (116.9±3.8mm Hg pre- vs. 112.1±3.4 mm Hg post-KNO(3), p<0.05) and aPWV (6.5±0.1 m/s pre- to 6.2±0.1 post-KNO(3), p<0.01).In contrast KCl capsules had no effect on any of the parameters measured.These findings demonstrate that although inorganic nitrate ingestion does not alter endothelial function per se, it does appear to improve blood flow, in combination with a reduction in blood pressure.

View Article: PubMed Central - PubMed

Affiliation: William Harvey Research Institute, Centre for Clinical Pharmacology, Barts & the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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Inorganic nitrate does not alter endothelial function in healthy volunteers. The effects of inorganic nitrate supplementation (KNO3, 8 mmol) or placebo (KCl, 8 mmol) on FMD. No significance found for comparisons between groups using Bonferroni post hoc tests, following 1-way ANOVA. Data are expressed as mean ± SEM (n = 13).
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f0010: Inorganic nitrate does not alter endothelial function in healthy volunteers. The effects of inorganic nitrate supplementation (KNO3, 8 mmol) or placebo (KCl, 8 mmol) on FMD. No significance found for comparisons between groups using Bonferroni post hoc tests, following 1-way ANOVA. Data are expressed as mean ± SEM (n = 13).

Mentions: There was no significant difference in baseline brachial artery diameter between the groups, with a mean diameter of 3.4 ± 0.2 mm (Table 2). In addition, there was no evidence of change in the FMD response after either inorganic nitrate supplementation or placebo (n = 13 for both) (Fig. 2).


Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers.

Bahra M, Kapil V, Pearl V, Ghosh S, Ahluwalia A - Nitric Oxide (2012)

Inorganic nitrate does not alter endothelial function in healthy volunteers. The effects of inorganic nitrate supplementation (KNO3, 8 mmol) or placebo (KCl, 8 mmol) on FMD. No significance found for comparisons between groups using Bonferroni post hoc tests, following 1-way ANOVA. Data are expressed as mean ± SEM (n = 13).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3405527&req=5

f0010: Inorganic nitrate does not alter endothelial function in healthy volunteers. The effects of inorganic nitrate supplementation (KNO3, 8 mmol) or placebo (KCl, 8 mmol) on FMD. No significance found for comparisons between groups using Bonferroni post hoc tests, following 1-way ANOVA. Data are expressed as mean ± SEM (n = 13).
Mentions: There was no significant difference in baseline brachial artery diameter between the groups, with a mean diameter of 3.4 ± 0.2 mm (Table 2). In addition, there was no evidence of change in the FMD response after either inorganic nitrate supplementation or placebo (n = 13 for both) (Fig. 2).

Bottom Line: In addition these changes in [nitrite] were associated with a decrease in systolic BP (116.9±3.8mm Hg pre- vs. 112.1±3.4 mm Hg post-KNO(3), p<0.05) and aPWV (6.5±0.1 m/s pre- to 6.2±0.1 post-KNO(3), p<0.01).In contrast KCl capsules had no effect on any of the parameters measured.These findings demonstrate that although inorganic nitrate ingestion does not alter endothelial function per se, it does appear to improve blood flow, in combination with a reduction in blood pressure.

View Article: PubMed Central - PubMed

Affiliation: William Harvey Research Institute, Centre for Clinical Pharmacology, Barts & the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Show MeSH
Related in: MedlinePlus