The biological effects of subacute inhalation of diesel exhaust following addition of cerium oxide nanoparticles in atherosclerosis-prone mice.
Bottom Line: Addition of CeO(2) to fuel resulted in a reduction of the number (30%) and surface area (10%) of the particles in the exhaust, whereas the gaseous co-pollutants were increased (6-8%).These results imply that addition of CeO(2) nanoparticles to fuel decreases the number of particles in exhaust and may reduce atherosclerotic burden associated with exposure to standard diesel fuel.However, further testing is required to ensure that such an approach is not associated with a chronic inflammatory response which may eventually cause long-term health effects.
Affiliation: National Institute for Public Health and the Environment, PO box 1, 3720 BA Bilthoven, The Netherlands. firstname.lastname@example.orgShow MeSH
Related in: MedlinePlus
Mentions: Overall, there was a trend that “standard” diesel exhaust increased the atherosclerotic burden, with an ∼35% increase in plaque size compared to control (Fig. 2(a)). This effect was not seen in the DCeE group. However, these differences did not achieve statistical significance (P=0.12 for Control vs DE; P=0.10 for Control vs DCeE). No dose related effect was seen and similar findings were observed if the data on the maximum plaque size (rather than burden throughout the artery) was used (data not shown).
Affiliation: National Institute for Public Health and the Environment, PO box 1, 3720 BA Bilthoven, The Netherlands. email@example.com