Different effects of age, adiposity and physical activity on the risk of ankle, wrist and hip fractures in postmenopausal women.
Bottom Line: All participants were linked to National Health Service cause-specific hospital records for day-case or overnight admissions.Compared with lean women (BMI<20 kg/m(2)), obese women (BMI≥30 kg/m(2)) had a three-fold increased risk of ankle fracture (RR=3.07; 95%CI 2.53-3.74), but a substantially reduced risk of wrist fracture and especially of hip fracture (RR=0.57; 0.51-0.64 and 0.23; 0.21-0.27, respectively).Physical activity was associated with a reduced risk of hip fracture but was not associated with ankle or wrist fracture risk.
Affiliation: Cancer Epidemiology Unit, University of Oxford, Oxford, UK. email@example.comShow MeSH
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Mentions: The baseline characteristics of the 1,155,304 postmenopausal women included in these analyses are shown in Table 1. Women were on average 56.0 (SD 4.8) years of age at recruitment, with a mean BMI of 26.2 (SD 4.7) kg/m2 at recruitment. Mean BMI decreased and mean alcohol consumption increased with increasing frequency of physical activity. During a mean follow-up of 8.3 years per woman (almost 10 million person-years), 6807 women had an incident ankle fracture, 9733 had an incident wrist fracture, and 5267 had an incident hip fracture. Our previous report, with shorter follow-up, included only 2582 women with an incident hip fracture . Age-specific incidence rates did not vary much for ankle fracture, but rates increased gradually with age for wrist fracture and very steeply with age for hip fracture (Fig. 1 and eTable 1). The estimated cumulative absolute risks per 100 women from ages 50 to 84 years were 2.5 (95%CI 2.2–2.8) for ankle fracture, 5.0 (95%CI 4.4–5.5) for wrist fracture, and 6.2 (95%CI 5.5–7.0) for hip fracture.
Affiliation: Cancer Epidemiology Unit, University of Oxford, Oxford, UK. firstname.lastname@example.org