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Effectiveness of CO2-insufflated endoscopic submucosal dissection with the duodenal balloon occlusion method for early esophageal or gastric cancer: a randomized case control prospective study.

Mori H, Kobara H, Fujihara S, Nishiyama N, Izuishi K, Ohkubo M, Rafiq K, Suzuki Y, Masaki T - BMC Gastroenterol (2012)

Bottom Line: No significant differences in blood ΔpH were found between the two groups.The VAS score for the occurrence of nausea due to abdominal distension after ESD indicated a significant difference (P = 0.031).ESD using the duodenal balloon occlusion method is effective for reduction of post-ESD intestinal CO2 gas volume, resulting in a lower total amount of CO2 insufflation during ESD and reducing harmful influences on the human body to some extent.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Gastroenterology and Neurology, 1750-1 Ikenobe, Miki, Kita, Kagawa, Japan. hiro4884@med.kagawa-u.ac.jp

ABSTRACT

Background: Endoscopic submucosal dissection (ESD) has typically been performed using air insufflation. Recently, however, insufflation of CO2 has been increasingly used to avoid complications. This prospective study was designed to compare the CO2 concentration, intestinal volume, and acid-base balance using the duodenal balloon procedure.

Methods: From June 2010 to February 2011, we enrolled 44 patients with esophageal or gastric cancer and randomly allocated them into two groups. We compared 22 patients undergoing CO2-insufflated ESD with a balloon placed into the duodenal bulb (duodenal balloon group) and 22 patients undergoing regular CO2-insufflated ESD (regular group). Three-dimensional computed tomography was performed before and after the procedure to measure intestinal volume. CO2 concentrations were measured every 10 minutes. The visual analogue system (VAS) scores for postoperative symptoms were recorded, and pH was measured immediately after the procedure. This was a prospective case control study randomized by the sealed envelope method.

Results: Intestinal CO2 gas volume before and after ESD was lower in the duodenal balloon group than in the regular group (P = 0.00027). The end-tidal CO2 level was significantly lower in the duodenal balloon group than in the regular group (P = 0.0001). No significant differences in blood ΔpH were found between the two groups. The VAS score for the occurrence of nausea due to abdominal distension after ESD indicated a significant difference (P = 0.031).

Conclusions: ESD using the duodenal balloon occlusion method is effective for reduction of post-ESD intestinal CO2 gas volume, resulting in a lower total amount of CO2 insufflation during ESD and reducing harmful influences on the human body to some extent.

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Duodenal balloon group: CT coronal image & 3D image. Two cases are depicted: Case 5 (duodenal balloon group) and Case 36 (regular group). 3DCT showed that the intestinal CO2 gas volume was relatively lower in the duodenal balloon group than in the regular group.
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Figure 6: Duodenal balloon group: CT coronal image & 3D image. Two cases are depicted: Case 5 (duodenal balloon group) and Case 36 (regular group). 3DCT showed that the intestinal CO2 gas volume was relatively lower in the duodenal balloon group than in the regular group.

Mentions: As shown in Figures 6 and 7, which depict Case 5 (duodenal group) and Case 36 (regular group), the intestinal CO2 gas volume just before and after ESD was lower in the duodenal balloon group than in the regular group.


Effectiveness of CO2-insufflated endoscopic submucosal dissection with the duodenal balloon occlusion method for early esophageal or gastric cancer: a randomized case control prospective study.

Mori H, Kobara H, Fujihara S, Nishiyama N, Izuishi K, Ohkubo M, Rafiq K, Suzuki Y, Masaki T - BMC Gastroenterol (2012)

Duodenal balloon group: CT coronal image & 3D image. Two cases are depicted: Case 5 (duodenal balloon group) and Case 36 (regular group). 3DCT showed that the intestinal CO2 gas volume was relatively lower in the duodenal balloon group than in the regular group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3405465&req=5

Figure 6: Duodenal balloon group: CT coronal image & 3D image. Two cases are depicted: Case 5 (duodenal balloon group) and Case 36 (regular group). 3DCT showed that the intestinal CO2 gas volume was relatively lower in the duodenal balloon group than in the regular group.
Mentions: As shown in Figures 6 and 7, which depict Case 5 (duodenal group) and Case 36 (regular group), the intestinal CO2 gas volume just before and after ESD was lower in the duodenal balloon group than in the regular group.

Bottom Line: No significant differences in blood ΔpH were found between the two groups.The VAS score for the occurrence of nausea due to abdominal distension after ESD indicated a significant difference (P = 0.031).ESD using the duodenal balloon occlusion method is effective for reduction of post-ESD intestinal CO2 gas volume, resulting in a lower total amount of CO2 insufflation during ESD and reducing harmful influences on the human body to some extent.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Gastroenterology and Neurology, 1750-1 Ikenobe, Miki, Kita, Kagawa, Japan. hiro4884@med.kagawa-u.ac.jp

ABSTRACT

Background: Endoscopic submucosal dissection (ESD) has typically been performed using air insufflation. Recently, however, insufflation of CO2 has been increasingly used to avoid complications. This prospective study was designed to compare the CO2 concentration, intestinal volume, and acid-base balance using the duodenal balloon procedure.

Methods: From June 2010 to February 2011, we enrolled 44 patients with esophageal or gastric cancer and randomly allocated them into two groups. We compared 22 patients undergoing CO2-insufflated ESD with a balloon placed into the duodenal bulb (duodenal balloon group) and 22 patients undergoing regular CO2-insufflated ESD (regular group). Three-dimensional computed tomography was performed before and after the procedure to measure intestinal volume. CO2 concentrations were measured every 10 minutes. The visual analogue system (VAS) scores for postoperative symptoms were recorded, and pH was measured immediately after the procedure. This was a prospective case control study randomized by the sealed envelope method.

Results: Intestinal CO2 gas volume before and after ESD was lower in the duodenal balloon group than in the regular group (P = 0.00027). The end-tidal CO2 level was significantly lower in the duodenal balloon group than in the regular group (P = 0.0001). No significant differences in blood ΔpH were found between the two groups. The VAS score for the occurrence of nausea due to abdominal distension after ESD indicated a significant difference (P = 0.031).

Conclusions: ESD using the duodenal balloon occlusion method is effective for reduction of post-ESD intestinal CO2 gas volume, resulting in a lower total amount of CO2 insufflation during ESD and reducing harmful influences on the human body to some extent.

Show MeSH
Related in: MedlinePlus