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Forms of antipsychotic therapy: improved individual outcomes under personalised treatment of schizophrenia focused on depression.

Babinkostova Z, Stefanovski B - EPMA J (2011)

Bottom Line: Early diagnosis, adequate differential diagnosis and promptly initiated interventions have been shown to reduce further deterioration of illness and to improve patients' quality of life.Atypical antipsychotics have advantages over typical in reducing depressive symptoms in the context of schizophrenia.Antidepressant augmentation of antipsychotic treatment in schizophrenic patients with depressive symptoms improves depressive symptomatology, particularly SSRI and SNRI augmentation.

View Article: PubMed Central - PubMed

Affiliation: University Clinic of Psychiatry, Belgradska bb, 1000 Skopje, Macedonia.

ABSTRACT
Depressive symptoms are common in schizophrenia and they can occur during any phase of the disorder. Early diagnosis, adequate differential diagnosis and promptly initiated interventions have been shown to reduce further deterioration of illness and to improve patients' quality of life. Common psychiatric rating scales for early detection of depressive symptoms in schizophrenia are Calgary Depression Scale for Schizophrenia and Hamilton Depression Rating Scale, but the most appropriate assessment instrument today regarding this topic is Calgary Depression Scale for Schizophrenia. Treatment of depression in schizophrenia consists of a combination of pharmacologic and psychosocial approach. Atypical antipsychotics have advantages over typical in reducing depressive symptoms in the context of schizophrenia. Most of the studies referred that clozapine, olanzapine, quetiapine and risperidone have an antidepressant spectrum of activity in patients with schizophrenia. Antidepressant augmentation of antipsychotic treatment in schizophrenic patients with depressive symptoms improves depressive symptomatology, particularly SSRI and SNRI augmentation.

No MeSH data available.


Related in: MedlinePlus

Total score on HAMD - typical vs. atypical oral antipsychotics
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Related In: Results  -  Collection


getmorefigures.php?uid=PMC3405399&req=5

Fig1: Total score on HAMD - typical vs. atypical oral antipsychotics

Mentions: Figure 1 presents the difference in depression intensity between the subgroup with typical oral antipsychotics and the subgroup with atypical oral antipsychotics.Fig. 1


Forms of antipsychotic therapy: improved individual outcomes under personalised treatment of schizophrenia focused on depression.

Babinkostova Z, Stefanovski B - EPMA J (2011)

Total score on HAMD - typical vs. atypical oral antipsychotics
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3405399&req=5

Fig1: Total score on HAMD - typical vs. atypical oral antipsychotics
Mentions: Figure 1 presents the difference in depression intensity between the subgroup with typical oral antipsychotics and the subgroup with atypical oral antipsychotics.Fig. 1

Bottom Line: Early diagnosis, adequate differential diagnosis and promptly initiated interventions have been shown to reduce further deterioration of illness and to improve patients' quality of life.Atypical antipsychotics have advantages over typical in reducing depressive symptoms in the context of schizophrenia.Antidepressant augmentation of antipsychotic treatment in schizophrenic patients with depressive symptoms improves depressive symptomatology, particularly SSRI and SNRI augmentation.

View Article: PubMed Central - PubMed

Affiliation: University Clinic of Psychiatry, Belgradska bb, 1000 Skopje, Macedonia.

ABSTRACT
Depressive symptoms are common in schizophrenia and they can occur during any phase of the disorder. Early diagnosis, adequate differential diagnosis and promptly initiated interventions have been shown to reduce further deterioration of illness and to improve patients' quality of life. Common psychiatric rating scales for early detection of depressive symptoms in schizophrenia are Calgary Depression Scale for Schizophrenia and Hamilton Depression Rating Scale, but the most appropriate assessment instrument today regarding this topic is Calgary Depression Scale for Schizophrenia. Treatment of depression in schizophrenia consists of a combination of pharmacologic and psychosocial approach. Atypical antipsychotics have advantages over typical in reducing depressive symptoms in the context of schizophrenia. Most of the studies referred that clozapine, olanzapine, quetiapine and risperidone have an antidepressant spectrum of activity in patients with schizophrenia. Antidepressant augmentation of antipsychotic treatment in schizophrenic patients with depressive symptoms improves depressive symptomatology, particularly SSRI and SNRI augmentation.

No MeSH data available.


Related in: MedlinePlus