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Birth asphyxia as the major complication in newborns: moving towards improved individual outcomes by prediction, targeted prevention and tailored medical care.

Golubnitschaja O, Yeghiazaryan K, Cebioglu M, Morelli M, Herrera-Marschitz M - EPMA J (2011)

Bottom Line: The severe insults often cause neurodegenerative diseases, mental retardation and epilepsies.The mild insults lead to so-called "minimal brain-damage disorders" such as attention deficits and hyperactivity, but can also be associated with the development of schizophrenia and life-long functional psychotic syndromes.Socio-economical impacts of educational measures and advanced strategies in development of robust diagnostic approaches targeted at effected molecular pathways, biomarker-candidates and potential drug-targets for tailored treatments are reviewed in the paper.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany.

ABSTRACT
Perinatal Asphyxia-oxygen deficit at delivery-can lead to severe hypoxic ischaemic organ damage in newborns followed by a fatal outcome or severe life-long pathologies. The severe insults often cause neurodegenerative diseases, mental retardation and epilepsies. The mild insults lead to so-called "minimal brain-damage disorders" such as attention deficits and hyperactivity, but can also be associated with the development of schizophrenia and life-long functional psychotic syndromes. Asphyxia followed by re-oxygenation can potentially lead to development of several neurodegenerative pathologies, diabetes type 2 and cancer. The task of individual prediction, targeted prevention and personalised treatments before a manifestation of the life-long chronic pathologies usually developed by newborns with asphyxic deficits, should be given the extraordinary priority in neonatology and paediatrics. Socio-economical impacts of educational measures and advanced strategies in development of robust diagnostic approaches targeted at effected molecular pathways, biomarker-candidates and potential drug-targets for tailored treatments are reviewed in the paper.

No MeSH data available.


Related in: MedlinePlus

Ratio of newborns with asphyxic deficits born to uneducated versus educated mothers. Data taken from [22]
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Fig6: Ratio of newborns with asphyxic deficits born to uneducated versus educated mothers. Data taken from [22]

Mentions: What are the potential measures that can be applied already now? One example of the high impact of educational measures to improve the healthcare system is given in Figs. 6 and 7.Fig. 6


Birth asphyxia as the major complication in newborns: moving towards improved individual outcomes by prediction, targeted prevention and tailored medical care.

Golubnitschaja O, Yeghiazaryan K, Cebioglu M, Morelli M, Herrera-Marschitz M - EPMA J (2011)

Ratio of newborns with asphyxic deficits born to uneducated versus educated mothers. Data taken from [22]
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3405378&req=5

Fig6: Ratio of newborns with asphyxic deficits born to uneducated versus educated mothers. Data taken from [22]
Mentions: What are the potential measures that can be applied already now? One example of the high impact of educational measures to improve the healthcare system is given in Figs. 6 and 7.Fig. 6

Bottom Line: The severe insults often cause neurodegenerative diseases, mental retardation and epilepsies.The mild insults lead to so-called "minimal brain-damage disorders" such as attention deficits and hyperactivity, but can also be associated with the development of schizophrenia and life-long functional psychotic syndromes.Socio-economical impacts of educational measures and advanced strategies in development of robust diagnostic approaches targeted at effected molecular pathways, biomarker-candidates and potential drug-targets for tailored treatments are reviewed in the paper.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany.

ABSTRACT
Perinatal Asphyxia-oxygen deficit at delivery-can lead to severe hypoxic ischaemic organ damage in newborns followed by a fatal outcome or severe life-long pathologies. The severe insults often cause neurodegenerative diseases, mental retardation and epilepsies. The mild insults lead to so-called "minimal brain-damage disorders" such as attention deficits and hyperactivity, but can also be associated with the development of schizophrenia and life-long functional psychotic syndromes. Asphyxia followed by re-oxygenation can potentially lead to development of several neurodegenerative pathologies, diabetes type 2 and cancer. The task of individual prediction, targeted prevention and personalised treatments before a manifestation of the life-long chronic pathologies usually developed by newborns with asphyxic deficits, should be given the extraordinary priority in neonatology and paediatrics. Socio-economical impacts of educational measures and advanced strategies in development of robust diagnostic approaches targeted at effected molecular pathways, biomarker-candidates and potential drug-targets for tailored treatments are reviewed in the paper.

No MeSH data available.


Related in: MedlinePlus