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Cancer predisposition in diabetics: risk factors considered for predictive diagnostics and targeted preventive measures.

Cebioglu M, Schild HH, Golubnitschaja O - EPMA J (2010)

Bottom Line: DNA-repair is a highly energy consuming process provoking increased mitochondrial activity.Particularly dangerous is a provoked activity of damaged mitochondria leading to a "vicious circle" lowering energy supply and potentiating ROS/RNS production.Much attention should be focused on preventive measures in diabetic healthcare, in order to restrict severe diabetes-related complications.

View Article: PubMed Central - PubMed

Affiliation: Division of Molecular/Experimental Radiology, Department of Radiology, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

ABSTRACT
Diabetes mellitus (DM) is a lifelong progressive disease with high morbidity and mortality worldwide. Whereas cardiovascular complications are well-known for DM, increasing evidence indicates that diabetics are predisposed to cancer. Understanding of molecular pathomechanisms of cancer in DM is of great importance. Dysregulation of glucose/insulin homeostasis leads to increased production of Reactive Oxygen/Nitrogen Species (ROS/RNS) and consequent damage to chromosomal/mitochondrial DNA, a frequent finding in DM. Long-term accumulation of modified/damaged DNA is well-acknowledged as triggering cancer. DNA-repair is a highly energy consuming process provoking increased mitochondrial activity. Particularly dangerous is a provoked activity of damaged mitochondria leading to a "vicious circle" lowering energy supply and potentiating ROS/RNS production. Mitochondrial dysfunction may be implicated in pathomechanisms of diabetes-related cancer. High risk for infectious disorders and induced viral proto-oncogenic activity may further contribute to cancer provocation. Much attention should be focused on preventive measures in diabetic healthcare, in order to restrict severe diabetes-related complications.

No MeSH data available.


Related in: MedlinePlus

Cancer risk for type 2 diabetics in North Italy in years 1987–1996 [9]
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Fig4: Cancer risk for type 2 diabetics in North Italy in years 1987–1996 [9]

Mentions: Similar studies carried out for type 2 diabetes demonstrate liver, pancreas and bladder cancer to be the leading types (Fig. 4).Fig. 4


Cancer predisposition in diabetics: risk factors considered for predictive diagnostics and targeted preventive measures.

Cebioglu M, Schild HH, Golubnitschaja O - EPMA J (2010)

Cancer risk for type 2 diabetics in North Italy in years 1987–1996 [9]
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3405313&req=5

Fig4: Cancer risk for type 2 diabetics in North Italy in years 1987–1996 [9]
Mentions: Similar studies carried out for type 2 diabetes demonstrate liver, pancreas and bladder cancer to be the leading types (Fig. 4).Fig. 4

Bottom Line: DNA-repair is a highly energy consuming process provoking increased mitochondrial activity.Particularly dangerous is a provoked activity of damaged mitochondria leading to a "vicious circle" lowering energy supply and potentiating ROS/RNS production.Much attention should be focused on preventive measures in diabetic healthcare, in order to restrict severe diabetes-related complications.

View Article: PubMed Central - PubMed

Affiliation: Division of Molecular/Experimental Radiology, Department of Radiology, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

ABSTRACT
Diabetes mellitus (DM) is a lifelong progressive disease with high morbidity and mortality worldwide. Whereas cardiovascular complications are well-known for DM, increasing evidence indicates that diabetics are predisposed to cancer. Understanding of molecular pathomechanisms of cancer in DM is of great importance. Dysregulation of glucose/insulin homeostasis leads to increased production of Reactive Oxygen/Nitrogen Species (ROS/RNS) and consequent damage to chromosomal/mitochondrial DNA, a frequent finding in DM. Long-term accumulation of modified/damaged DNA is well-acknowledged as triggering cancer. DNA-repair is a highly energy consuming process provoking increased mitochondrial activity. Particularly dangerous is a provoked activity of damaged mitochondria leading to a "vicious circle" lowering energy supply and potentiating ROS/RNS production. Mitochondrial dysfunction may be implicated in pathomechanisms of diabetes-related cancer. High risk for infectious disorders and induced viral proto-oncogenic activity may further contribute to cancer provocation. Much attention should be focused on preventive measures in diabetic healthcare, in order to restrict severe diabetes-related complications.

No MeSH data available.


Related in: MedlinePlus