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Cancer predisposition in diabetics: risk factors considered for predictive diagnostics and targeted preventive measures.

Cebioglu M, Schild HH, Golubnitschaja O - EPMA J (2010)

Bottom Line: DNA-repair is a highly energy consuming process provoking increased mitochondrial activity.Particularly dangerous is a provoked activity of damaged mitochondria leading to a "vicious circle" lowering energy supply and potentiating ROS/RNS production.Much attention should be focused on preventive measures in diabetic healthcare, in order to restrict severe diabetes-related complications.

View Article: PubMed Central - PubMed

Affiliation: Division of Molecular/Experimental Radiology, Department of Radiology, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

ABSTRACT
Diabetes mellitus (DM) is a lifelong progressive disease with high morbidity and mortality worldwide. Whereas cardiovascular complications are well-known for DM, increasing evidence indicates that diabetics are predisposed to cancer. Understanding of molecular pathomechanisms of cancer in DM is of great importance. Dysregulation of glucose/insulin homeostasis leads to increased production of Reactive Oxygen/Nitrogen Species (ROS/RNS) and consequent damage to chromosomal/mitochondrial DNA, a frequent finding in DM. Long-term accumulation of modified/damaged DNA is well-acknowledged as triggering cancer. DNA-repair is a highly energy consuming process provoking increased mitochondrial activity. Particularly dangerous is a provoked activity of damaged mitochondria leading to a "vicious circle" lowering energy supply and potentiating ROS/RNS production. Mitochondrial dysfunction may be implicated in pathomechanisms of diabetes-related cancer. High risk for infectious disorders and induced viral proto-oncogenic activity may further contribute to cancer provocation. Much attention should be focused on preventive measures in diabetic healthcare, in order to restrict severe diabetes-related complications.

No MeSH data available.


Related in: MedlinePlus

General predisposition of diabetics to single cancer types: breast [2], endometrial [3], colorectal [4], pancreas [5], and liver [6] cancers
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Fig1: General predisposition of diabetics to single cancer types: breast [2], endometrial [3], colorectal [4], pancreas [5], and liver [6] cancers

Mentions: Diabetes mellitus (DM) is a group of metabolic disorders, mainly characterized by impaired glucose metabolism and consequent hyperglycemia as the common feature. Whereas cardiovascular complications are well described for DM [1], it is a relatively new consideration that diabetic patients are highly predisposed to cancer. In spite of some ethnic-, gender-, and age-specific differences, significantly increased risk of liver, pancreas, bladder and digestive tract cancer types is generally recognized for DM-patients (Fig. 1).Fig. 1


Cancer predisposition in diabetics: risk factors considered for predictive diagnostics and targeted preventive measures.

Cebioglu M, Schild HH, Golubnitschaja O - EPMA J (2010)

General predisposition of diabetics to single cancer types: breast [2], endometrial [3], colorectal [4], pancreas [5], and liver [6] cancers
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3405313&req=5

Fig1: General predisposition of diabetics to single cancer types: breast [2], endometrial [3], colorectal [4], pancreas [5], and liver [6] cancers
Mentions: Diabetes mellitus (DM) is a group of metabolic disorders, mainly characterized by impaired glucose metabolism and consequent hyperglycemia as the common feature. Whereas cardiovascular complications are well described for DM [1], it is a relatively new consideration that diabetic patients are highly predisposed to cancer. In spite of some ethnic-, gender-, and age-specific differences, significantly increased risk of liver, pancreas, bladder and digestive tract cancer types is generally recognized for DM-patients (Fig. 1).Fig. 1

Bottom Line: DNA-repair is a highly energy consuming process provoking increased mitochondrial activity.Particularly dangerous is a provoked activity of damaged mitochondria leading to a "vicious circle" lowering energy supply and potentiating ROS/RNS production.Much attention should be focused on preventive measures in diabetic healthcare, in order to restrict severe diabetes-related complications.

View Article: PubMed Central - PubMed

Affiliation: Division of Molecular/Experimental Radiology, Department of Radiology, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

ABSTRACT
Diabetes mellitus (DM) is a lifelong progressive disease with high morbidity and mortality worldwide. Whereas cardiovascular complications are well-known for DM, increasing evidence indicates that diabetics are predisposed to cancer. Understanding of molecular pathomechanisms of cancer in DM is of great importance. Dysregulation of glucose/insulin homeostasis leads to increased production of Reactive Oxygen/Nitrogen Species (ROS/RNS) and consequent damage to chromosomal/mitochondrial DNA, a frequent finding in DM. Long-term accumulation of modified/damaged DNA is well-acknowledged as triggering cancer. DNA-repair is a highly energy consuming process provoking increased mitochondrial activity. Particularly dangerous is a provoked activity of damaged mitochondria leading to a "vicious circle" lowering energy supply and potentiating ROS/RNS production. Mitochondrial dysfunction may be implicated in pathomechanisms of diabetes-related cancer. High risk for infectious disorders and induced viral proto-oncogenic activity may further contribute to cancer provocation. Much attention should be focused on preventive measures in diabetic healthcare, in order to restrict severe diabetes-related complications.

No MeSH data available.


Related in: MedlinePlus