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Drug delivery systems: Advanced technologies potentially applicable in personalized treatments.

Coelho JF, Ferreira PC, Alves P, Cordeiro R, Fonseca AC, Góis JR, Gil MH - EPMA J (2010)

Bottom Line: Advanced drug delivery systems (DDS) present indubitable benefits for drug administration.The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers.In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, University of Coimbra, 3030-290 Coimbra, Portugal.

ABSTRACT
Advanced drug delivery systems (DDS) present indubitable benefits for drug administration. Over the past three decades, new approaches have been suggested for the development of novel carriers for drug delivery. In this review, we describe general concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes). This review is composed of two parts. The first part provides an overview on currently available drug delivery technologies including a brief history on the development of these systems and some of the research strategies applied. The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers. Their synthesis using controlled-living radical polymerization strategy is described. In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

No MeSH data available.


Related in: MedlinePlus

Biodegradable chemical linkages
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Fig3: Biodegradable chemical linkages

Mentions: Chemically controlled systems include polymer-drug conjugates in which drug molecules are linked to a polymeric backbone often by means of a spacer molecule. Once inside the body the linkage between polymer carrier and the drug is cleaved either by hydrolysis or enzyme cleavage. Different types of biodegradable or hydrolysable chemical linkages are used to attach the drug to the polymer backbone (Fig. 3) [15].Fig. 3


Drug delivery systems: Advanced technologies potentially applicable in personalized treatments.

Coelho JF, Ferreira PC, Alves P, Cordeiro R, Fonseca AC, Góis JR, Gil MH - EPMA J (2010)

Biodegradable chemical linkages
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3405312&req=5

Fig3: Biodegradable chemical linkages
Mentions: Chemically controlled systems include polymer-drug conjugates in which drug molecules are linked to a polymeric backbone often by means of a spacer molecule. Once inside the body the linkage between polymer carrier and the drug is cleaved either by hydrolysis or enzyme cleavage. Different types of biodegradable or hydrolysable chemical linkages are used to attach the drug to the polymer backbone (Fig. 3) [15].Fig. 3

Bottom Line: Advanced drug delivery systems (DDS) present indubitable benefits for drug administration.The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers.In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, University of Coimbra, 3030-290 Coimbra, Portugal.

ABSTRACT
Advanced drug delivery systems (DDS) present indubitable benefits for drug administration. Over the past three decades, new approaches have been suggested for the development of novel carriers for drug delivery. In this review, we describe general concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes). This review is composed of two parts. The first part provides an overview on currently available drug delivery technologies including a brief history on the development of these systems and some of the research strategies applied. The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers. Their synthesis using controlled-living radical polymerization strategy is described. In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

No MeSH data available.


Related in: MedlinePlus