Limits...
Drug delivery systems: Advanced technologies potentially applicable in personalized treatments.

Coelho JF, Ferreira PC, Alves P, Cordeiro R, Fonseca AC, Góis JR, Gil MH - EPMA J (2010)

Bottom Line: Advanced drug delivery systems (DDS) present indubitable benefits for drug administration.The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers.In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, University of Coimbra, 3030-290 Coimbra, Portugal.

ABSTRACT
Advanced drug delivery systems (DDS) present indubitable benefits for drug administration. Over the past three decades, new approaches have been suggested for the development of novel carriers for drug delivery. In this review, we describe general concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes). This review is composed of two parts. The first part provides an overview on currently available drug delivery technologies including a brief history on the development of these systems and some of the research strategies applied. The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers. Their synthesis using controlled-living radical polymerization strategy is described. In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

No MeSH data available.


Related in: MedlinePlus

1,3-Dipolar cycloaddition between azides and alkynes
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3405312&req=5

Fig38: 1,3-Dipolar cycloaddition between azides and alkynes

Mentions: The application of CLRP and “click chemistry” offers a robust method to produce new polymers with tailor-made features aiming to improve the biocompatibility and biodegradability of the DDS. “Click chemistry” represents a philosophy inspired by the simplicity and efficiency of the chemistry of the mother Nature. The concept was introduced by Sharpless and co-authors [214]. The main objective is to establish straightforward and highly selective reaction systems to synthesize precise structures. The most representative reaction of “click chemistry” is the copper catalyzed Huisgen 1,3 –dipolar cycloaddition of azides and terminal alkynes [215, 216] (Fig. 38).Fig. 38


Drug delivery systems: Advanced technologies potentially applicable in personalized treatments.

Coelho JF, Ferreira PC, Alves P, Cordeiro R, Fonseca AC, Góis JR, Gil MH - EPMA J (2010)

1,3-Dipolar cycloaddition between azides and alkynes
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3405312&req=5

Fig38: 1,3-Dipolar cycloaddition between azides and alkynes
Mentions: The application of CLRP and “click chemistry” offers a robust method to produce new polymers with tailor-made features aiming to improve the biocompatibility and biodegradability of the DDS. “Click chemistry” represents a philosophy inspired by the simplicity and efficiency of the chemistry of the mother Nature. The concept was introduced by Sharpless and co-authors [214]. The main objective is to establish straightforward and highly selective reaction systems to synthesize precise structures. The most representative reaction of “click chemistry” is the copper catalyzed Huisgen 1,3 –dipolar cycloaddition of azides and terminal alkynes [215, 216] (Fig. 38).Fig. 38

Bottom Line: Advanced drug delivery systems (DDS) present indubitable benefits for drug administration.The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers.In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, University of Coimbra, 3030-290 Coimbra, Portugal.

ABSTRACT
Advanced drug delivery systems (DDS) present indubitable benefits for drug administration. Over the past three decades, new approaches have been suggested for the development of novel carriers for drug delivery. In this review, we describe general concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes). This review is composed of two parts. The first part provides an overview on currently available drug delivery technologies including a brief history on the development of these systems and some of the research strategies applied. The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers. Their synthesis using controlled-living radical polymerization strategy is described. In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

No MeSH data available.


Related in: MedlinePlus