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Drug delivery systems: Advanced technologies potentially applicable in personalized treatments.

Coelho JF, Ferreira PC, Alves P, Cordeiro R, Fonseca AC, Góis JR, Gil MH - EPMA J (2010)

Bottom Line: Advanced drug delivery systems (DDS) present indubitable benefits for drug administration.The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers.In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, University of Coimbra, 3030-290 Coimbra, Portugal.

ABSTRACT
Advanced drug delivery systems (DDS) present indubitable benefits for drug administration. Over the past three decades, new approaches have been suggested for the development of novel carriers for drug delivery. In this review, we describe general concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes). This review is composed of two parts. The first part provides an overview on currently available drug delivery technologies including a brief history on the development of these systems and some of the research strategies applied. The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers. Their synthesis using controlled-living radical polymerization strategy is described. In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

No MeSH data available.


Related in: MedlinePlus

Schematic representation of the synthesis of P(VAB63-b-MEMA123) reported by Armes and co-authors (adapted from [202])
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Fig34: Schematic representation of the synthesis of P(VAB63-b-MEMA123) reported by Armes and co-authors (adapted from [202])

Mentions: Armes and co-authors reported a novel zwitterionic poly(4-vinylbenzoic acid-block-2-N-(morpholino)ethyl methacrylate) (P(VBA(63)-b-MEMA(123))) [202] diblock copolymer synthesized via ATRP using protecting group chemistry for the acidic residues (Fig. 34). VBA core micelles were formed at pH below 6, while above pH 6 the block copolymer dissolved unimers. Very interesting was the fact that under alkakine media and in the presence of salt (Na2S2O4) or at elevated temperature, well-defined MEMA-core micelles were formed. The MEMA is a very interesting polymer since it displays both pH and temperature sensitive behaviour.Fig. 34


Drug delivery systems: Advanced technologies potentially applicable in personalized treatments.

Coelho JF, Ferreira PC, Alves P, Cordeiro R, Fonseca AC, Góis JR, Gil MH - EPMA J (2010)

Schematic representation of the synthesis of P(VAB63-b-MEMA123) reported by Armes and co-authors (adapted from [202])
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3405312&req=5

Fig34: Schematic representation of the synthesis of P(VAB63-b-MEMA123) reported by Armes and co-authors (adapted from [202])
Mentions: Armes and co-authors reported a novel zwitterionic poly(4-vinylbenzoic acid-block-2-N-(morpholino)ethyl methacrylate) (P(VBA(63)-b-MEMA(123))) [202] diblock copolymer synthesized via ATRP using protecting group chemistry for the acidic residues (Fig. 34). VBA core micelles were formed at pH below 6, while above pH 6 the block copolymer dissolved unimers. Very interesting was the fact that under alkakine media and in the presence of salt (Na2S2O4) or at elevated temperature, well-defined MEMA-core micelles were formed. The MEMA is a very interesting polymer since it displays both pH and temperature sensitive behaviour.Fig. 34

Bottom Line: Advanced drug delivery systems (DDS) present indubitable benefits for drug administration.The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers.In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, University of Coimbra, 3030-290 Coimbra, Portugal.

ABSTRACT
Advanced drug delivery systems (DDS) present indubitable benefits for drug administration. Over the past three decades, new approaches have been suggested for the development of novel carriers for drug delivery. In this review, we describe general concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes). This review is composed of two parts. The first part provides an overview on currently available drug delivery technologies including a brief history on the development of these systems and some of the research strategies applied. The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers. Their synthesis using controlled-living radical polymerization strategy is described. In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

No MeSH data available.


Related in: MedlinePlus